Clinical trials: PHYSIOLOGICAL PHENOMENA
Infant Nutritional Physiological Phenomena, Infant Formula
Effect of Partially Hydrolyzed, Whey-based Infant Formulas on Growth and Tolerability in Healthy Term Infants
This study will assess the effect of partially hydrolyzed, whey-based infant formulas on growth and gastrointestinal tolerance in healthy term infants.
- Conditions
- Infant Nutritional Physiological Phenomena, Infant Formula, Infant Health, Infant Development
- Trial name
- NCT05868408
- Testing
- Control Formula, Experimental Formula 1, Experimental Formula 2
- Where
- 5 sites in Philippines, Saudi Arabia
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Nutritional Physiological Phenomena, Obesity
The DEB Pilot Study
The purpose of the current study is to test if weight change is differentially affected by consumption of foods that are identical in carbohydrate (i.e. sugar) but vary in food form over 1 month.
- Trial name
- DEB Pilot (NCT03190993)
- Testing
- Sugar Sweetened Solid Treatment, Sugar Sweetened Beverage Treatment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Cardiovascular Physiological Phenomena, Endothelial Nitric Oxide Synthase
The Impact of Fish-oil Fatty Acids on Postprandial Vascular Reactivity
The primary aim of this study is to determine the impact of individual fish oil fatty acids on vascular reactivity and to identify underlying physiological and molecular mechanism of any observed effects.
- Conditions
- Cardiovascular Physiological Phenomena, Endothelial Nitric Oxide Synthase, Eicosapentaenoic Acid, Docosahexaenoic Acid (All-Z Isomer)
- Trial name
- FOFA (NCT01692431)
- Testing
- EPA, DHA
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Sepsis, Circulatory Failure
Respiratory Variations For Predicting Fluid Responsiveness 2
Objectives: To investigate whether respiratory variations of inferior vena cava diameters (cIVC) predict fluid responsiveness in spontaneously breathing patients with septic acute circulatory failure and irregular heartbeats.
- Conditions
- Sepsis, Circulatory Failure, Respiratory Physiological Phenomena
- Trial name
- ReVaPreF2 (NCT03066375)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Lille
Intubation Complication, Cardiovascular Morbidity
The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation
Justification and Objectives: The hemodynamic response to stimuli of the airways is a common phenomenon and its control is important to decrease systemic repercussions.
- Trial name
- NCT02359370
- Testing
- Lidocaine, Magnesium Sulphate
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Nutritional Physiological Phenomena, Health
The Nutrition Researcher Cohort 2014 Study
The primary objective of the planned Nutrition Research Cohort (NRC) n250 study is to develop and evaluate the open access Nutrition Researcher Cohort for gathering personal health data from nutrition researchers, including…
- Conditions
- Nutritional Physiological Phenomena, Health, Biological Markers
- Trial name
- NRC250 (NCT02522390)
- Testing
- Research activities
- Where
- 12 sites in Austria, Belgium and 10 more
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- TNO
Metabolic Syndrome, Vascular Compliance
Orange Juice, Hesperidin and Their Role in Vascular Health Benefit
Although epidemiological studies have associated the consumption of sugary beverages with adverse health effects, experimental studies have demonstrated that the metabolic response of the human body to fruit juice as compared to…
- Conditions
- Metabolic Syndrome, Vascular Compliance, Predisposition to Cardiovascular Disease
- Trial name
- HESPER-HEALTH (NCT04731987)
- Testing
- Beverage consumption
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity, Cardiovascular Physiological Phenomena
Metabolic Effects of Natriuretic Peptide Hormones
Accumulating evidence suggests that the natriuretic peptide (NP) hormonal system has important effects on metabolism. However, more information is needed to better understand the effects of NPs on metabolism in humans.
- Conditions
- Obesity, Cardiovascular Physiological Phenomena, Metabolism
- Trial name
- MENP (NCT03397966)
- Testing
- recombinant human BNP(1-32)
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Respiratory Physiological Phenomena
Functional Residual Capacity Measured by Capnography in Ventilated Patients
Changes in body position during anesthesia can alter functional residual capacity and gas exchange. The monitoring of such changes in functional residual capacity is difficult at the bedside.
- Trial name
- NCT03693352
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Sleep Deprivation
Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function.
- Trial name
- NCT00272233
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yale University
Sports Nutritional Physiological Phenomena
Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation
The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance.
- Trial name
- NCT03505970
- Testing
- Sodium bicarbonate, Maltodextrin
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Psychological Phenomena and Processes, Nutrition Physiological Phenomena
The Effects of Fiber on Appetite and Digestion Hormones
In this research study, investigators are interested in how certain dietary fibers in the diet affect certain hormones released from your intestine after eating and how these influence your appetite.
- Trial name
- FS (NCT01050101)
- Testing
- No fiber, Low GI high fiber viscous meal, Low GI high fiber non-viscous
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Diabetes, Diabetes Mellitus, Type 2
Physiological Concept of Insulin Therapy in Subjects With Type 2 Diabetes
This study is conducted in Europe. The aim of the study was to evaluate the safety and efficacy of biphasic insulin aspart 30 (NovoMix® 30) when switching to a modern premix insulin analogue treatment compared to previous insulin…
- Trial name
- NCT01536639
- Testing
- biphasic insulin aspart 30
- Where
- Slovakia
- Volunteers
- 454 people
- Sponsor
- Novo Nordisk A/S
PHYSIOLOGICAL PHENOMENA
Importance of Liver Innervation for the Osmopressor Response in Humans
In patients with autonomic dysfunction water drinking elicits a pressor response mediated by sympathetic activation. If any, in healthy subjects there is only a slight increase in blood pressure.
- Trial name
- HEP-Reflex (NCT01237431)
- Testing
- 500ml water intake
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Postmenopausal Syndrome, Muscle Weakness
The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women
The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed…
- Trial name
- NCT02434185
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Nutritional Physiological Phenomena
Gene Polymorphism of Taste Receptors and Circulating Endocannabinoids in Normal Weight and Obese Subjects
The study aims at evaluating in normal weight and obese subjects those factors such as taste sensitivity and circulating endocannabinoids in influencing dietary choice and thereby lipid and energy metabolism in order to design…
- Trial name
- NCT02729584
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Heart Function Tests, Hemodynamics
Impact of Non-invasive Positive Pressure Ventilation on Cardiac Function and Echocardiographic Parameters
Cardiologists and intensive care specialists are confronted daily with mechanically ventilated patients exhibiting cardiac failure.
- Conditions
- Heart Function Tests, Hemodynamics, Noninvasive Ventilation, Circulatory and Respiratory Physiological Phenomena
- Trial name
- NCT02267291
- Testing
- Non-invasive positive pressure ventilation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Esophageal Neoplasms
Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest cavity could increase lung collapse and…
- Trial name
- NCT02330536
- Testing
- Insufflation of carbon dioxide (CO2)
- Volunteers
- 232 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Healthy Adults (Hospital Oncology Ward), Physiological Phenomena (e.g.HRV Parameters)
Short-term Effects of Sound-bed Music Therapy in Healthy Caregivers of a Hospital Oncology Ward (MTO_03)
The purpose of this study is to determine the effects of live sound-bed music on physiological and psychological parameters in staff of a hospital oncology ward.
- Conditions
- Healthy Adults (Hospital Oncology Ward), Physiological Phenomena (e.g.HRV Parameters), Morphology
- Trial name
- MTO_03 (NCT02255916)
- Testing
- Music
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Sports Nutritional Physiological Phenomena
24-Wk β-Alanine Ingestion on Muscle Taurine and Clinical Blood Parameters in Healthy Males
Although β-alanine (BA) has been shown to be an effective ergogenic aid, little information exists on the safety of chronic supplementation despite potential concerns.
- Trial name
- NCT03655041
- Testing
- Beta-alanine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo