Clinical trials: PLATELET AGGREGATION
Healthy Subjects, Hypomagnesemia
The Absorption of Magnesium Oxide Compared to Citrate in Healthy Subjects
The magnesium food content in the Western world is consistently reducing. Hypomagnesemia is common in hospitalized patients, especially in the elderly with coronary artery disease (CAD) and/or those with chronic heart failure.
- Trial name
- NCT00994006
- Testing
- Magnesium oxide, Magnesium citrate
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cardiovascular Diseases
In Vitro Interaction Between Ticagrelor and Its Active Metabolite and Their Effects on Salicylic Acid
This is a in-vitro study to evaluate the pharmacodynamic interaction between ticagrelor and its active metabolite (AR-C124910XX) and their effects on the pharmacodynamics of salicylic acid.
- Trial name
- In_vitro_PAT (NCT01777516)
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Blood Platelets, Clopidogrel
PACT (Platelet Activity After Clopidogrel Termination)
Clopidogrel is a medication that is used to decrease the ability of platelets to form blood clots. The theory has been proposed that, in patients with coronary artery disease or stroke, increased platelet function after…
- Trial name
- PACT (NCT00619073)
- Testing
- clopidogrel + aspirin, Aspirin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Patent Ductus Arterioses
The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants
Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure.
- Trial name
- PFA100 (NCT02010879)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara University
CABG Surgery, Cold Blood Cardioplegia, Coagulation Profile and Platelet Function
Hypothermic Versus Normothermic Cardiac Bypass in Patients Undergoing CABG Surgery, Effect on Coagulation; Randomized Controlled Trial
On-pump CABG surgery deleteriously affects hematological and coagulation profiles of patients and this effect was accentuated by the use of cold bypass.
- Trial name
- NCT04148404
- Testing
- Normothermic group
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Bypass Grafting, Open Heart Surgery
Assessment of Platelet Function in Patients Undergoing Open Heart Surgery
The purpose of this external evaluation is to assess the system functionality and analytical performance of the Saturn Investigational Instrument (next generation VerifyNow instrument) and associated cartridge currently under…
- Conditions
- Coronary Artery Bypass Grafting, Open Heart Surgery, Aortic Surgery or Redo Surgery, On-pump Double or Triple Valve Procedures
- Trial name
- Saturn (NCT05441358)
- Testing
- Open Heart Surgery
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Eclampsia Preeclampsia
Magnesium and Platelet Function Testing
Magnesium has built up the reputation of a 'natural calcium antagonist'. However, the exact effect of magnesium on coagulation and more specifically on platelet function is still disputed.
- Trial name
- MgCedVD (NCT03143647)
- Testing
- Collect a study-specific blood sample of healthy subjects
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Platelet Aggregation and Inflammation
Cardioprotective Properties of Natural Anti-Platelet Activating Factor Extract From Winery By-products in Healthy Women
The purpose of this study is to investigate the anti-platelet and anti-inflammatory properties of a winery by-products extract as well as to detect extract compounds and their metabolites in biological fluids.
- Trial name
- NAPE (NCT04436263)
- Testing
- Supplement
- Where
- Greece
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Adverse Effect of Antithrombotic Drugs
Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate
This is a phase I clinical trial in healthy volunteers comparing the effect of lysine acetylsalicylate or aspirin on platelet function.
- Trial name
- ECCLIPSE (NCT02243137)
- Testing
- acetylsalicylic acid, prasugrel, lysine acetylsalicylate
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- David Vivas
Platelet Aggregation Inhibitors, Coronary Heart Disease
Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study)
One of the most common ways for preventing coronary heart disease (CHD) is to take aspirin or clopidogrel. However, studies have shown that not all people respond to these medications.
- Trial name
- NCT00799396
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 682 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Blood Donation
Cookies for Platelets
This study aims to evaluate the effects of glucose consumption (in the form of Christmas cookies) on platelet function, as well as the motivation and willingness of healthy platelet donors.The main hypothesis is that consuming…
- Trial name
- c4p (NCT07890467)
- Testing
- Christmas cookies (home-made)
- Where
- Austria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Blood Coagulation, Platelet Function
Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation
This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.
- Trial name
- NCT02594345
- Testing
- in vitro study
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Pulpitis - Irreversible, Tooth Decay
Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth
Of all the various pulpotomy medicaments that have been studied till to date, three agents have been selected for this study to compare their efficacy.
- Trial name
- NCT05266859
- Testing
- Calcium hydroxide, MTA, PRF
- Where
- Pakistan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Liaquat College of Medicine and Dentistry
Pharmacodynamics
Clopidogrel And Ticagrelor in Healthy Subjects
To evaluate the pharmacodynamics of a lower Ticagrelor dose in healthy Korean volunteers compared with standard Clopidogrel agent.
- Trial name
- NCT02086903
- Testing
- Ticagrelor 90 mg, Clopidogrel 600 mg
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Coronary Artery Disease
The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties.
- Trial name
- ECLIPSE (NCT06567678)
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Trinidad and Tobago
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Hypertension
Chlorthalidone and HCTZ Impacts on Platelet Activation
This will be a randomized, double-blinded, three-period crossover study of platelet activation and aggregation in 30 non-smoking healthy volunteers comparing chlorthalidone (CTD), hydrochlorothiazide (HCTZ), and aspirin (ASA…
- Trial name
- NCT02100462
- Testing
- Chlorthalidone 12.5 mg, Hydrochlorothiazide 25 mg, Aspirin 81 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Creighton University