Clinical trials: PMDD
PMDD, Premenstrual Dysphoric Disorder (PMDD)
Identification and Validation of Epigenetic Biomarkers of PMDD
This research is being done to examine epigenetic markers and mood changes across the menstrual cycle, particularly in premenstrual dysphoric disorder (PMDD).
- Conditions
- PMDD, Premenstrual Dysphoric Disorder (PMDD), Premenstrual Syndrome-PMS, Premenstrual Syndrome
- Trial name
- BIO (NCT06771583)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Depression, Major Depressive Disorder
Single Session of tACS in a Depressive Episode
Purpose: Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on healthy participants and participants with mood disorders.
- Conditions
- Depression, Major Depressive Disorder, Premenstrual Dysphoric Disorder, Depressive Episode
- Trial name
- SSDE (NCT03449979)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Premenstrual Dysphoric Disorder
Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study
This research study will look at brain and symptom differences among women with severe premenstrual mood symptoms. One goal of this study is to look at the effects of taking a nasal spray containing oxytocin (a hormone made in…
- Trial name
- NCT02508103
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Premenstrual Dysphoric Disorder, Premenstrual Syndrome
The Role of GABA and Neurosteroids in Premenstrual Dysphoric Disorder
The purpose of the study proposed is to investigate the role of neurosteroids and GABA in the pathophysiology and treatment of premenstrual dysphoric disorder (PMDD) by 1) measuring cortical gama-aminobutyric acid levels (GABA…
- Trial name
- NCT00678574
- Testing
- fluoxetine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Autism Spectrum Disorder, Borderline Personality Disorder BPD
Perimenstrual Symptoms and Emotional Dysregulation in Autism
Emotional dysregulation (ED) is defined by difficulties in modulating the experience and expression of emotions, which are characterized by particularly marked reactivity, intensity, and duration.
- Conditions
- Autism Spectrum Disorder, Borderline Personality Disorder BPD, a Premenstrual Dysphoric Disorder (PMDD)
- Trial name
- MEDEA (NCT06871345)
- Testing
- Semi-structured interviews SCID, Self-report questionnaires, Momentary Ecological Assessment (EMA)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
MDD, PMDD
Stress, Inflammation and Neuroimaging in Major Depressive Disorder as Compared to Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a sex-specific depressive disorder where depressive symptom severity drastically changes in relation to menstrual cycle phase.
- Trial name
- NCT06130371
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Premenstrual Dysphoric Disorder, PMDD
The SPARK-PMDD Study
Scientists have found that the immune system, the body's system dedicated to fighting infections, can be in a state of "hyperactivity" (i.e., more active than you would normally expect) in some people with depression and…
- Conditions
- Premenstrual Dysphoric Disorder, PMDD, Premenstrual Dysphoric Disorder ( PMDD), Premenstrual Dysphoric Disorder (PMDD)
- Trial name
- SPARK-PMDD (NCT07771426)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- King's College London
Premenstrual Dysphoric Disorder ( PMDD)
To Establish Whether Individuals With Premenstrual Dysphoric Disorder (PMDD) Demonstrate a Different Luteal-phase Sex Hormone Profile and Ratio Compared With Asymptomatic Controls.
The aim of this project is to compare the ovarian hormone levels 7 days after ovulation and progesterone:oestradiol ratios between PMDD individuals and a control cohort (case control study).
- Trial name
- NCT07686718
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Epilepsy
Premenstrual Dysphoric Disorder and Antiepileptic Drugs
This study is being done to determine if there are differences in mood during the menstrual cycle among women with epilepsy who take various different antiepileptic drugs and women without epilepsy.
- Trial name
- NCT00612235
- Testing
- Lamotrigine, Levetiracetam, Carbamazepine
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Premenstrual Syndrome
Fibromyalgia and Psychiatric Symptoms Among PMS and PMDD Patients
Assessing FM and psychiatric disorder in patients suffering from PMS or PMDD
- Trial name
- NCT00229346
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Premenstrual Disorder
The Effect of Progressive Muscle Relaxation Exercises on Premenstrual Syndrome, Anxiety, and Tendency to Violence in Young Women
This study results will provide evidence on the effectiveness of Progressive Muscle Relaxation Exercises (PMRE) as a complementary method in improving Premenstrual Syndrome (PMS), an important women's health issue.
- Trial name
- NCT06909955
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Healthy, Premenstrual Dysphoric Disorder
The Effects of Mixhers HERTIME Supplements on Menstrual Symptoms
The purpose of this study is to assess Mixhers HERTIME supplements efficacy in alleviating menstrual cycle symptoms.
- Conditions
- Healthy, Premenstrual Dysphoric Disorder, Premenstrual Syndrome
- Trial name
- NCT06136104
- Testing
- Mixhers HERTIME
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Premenstrual Dysphoric Disorder
Combined Effect of Tryptophan Rich Diet and Acupuncture on Depression Related to Premenstrual Dysphoric Disorder
Premenstrual Dysphoric Disorder (PMDD) is a severe form of premenstrual syndrome (PMS) affecting up to 8% of reproductive age women.
- Trial name
- NCT05813366
- Testing
- Acupuncture, Tryptophan-Rich Diet, Vitamin B6 Supplementation
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Cairo University
Premenstrual Dysphoric Disorder (PMDD)
Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a severe affective disorder impacting millions of women worldwide, thought to be due to altered sensitivity to hormone fluctuations across the menstrual cycle.
- Trial name
- BLOOM (NCT06704594)
- Testing
- sertraline 50 mg daily
- Where
- 2 sites in United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Premenstrual Syndrome
Altered Calcium and Vitamin D in PMDD or Severe PMS
Osteoporosis has become one of the most widely recognized disorders of our times affecting an estimated 25 million women in this country.
- Trial name
- NCT00005119
- Testing
- Measures of calcium and bone turnover
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Premenstrual Dysphoric Disorder
Levetiracetam in the Treatment of Patients With Premenstrual Dysphoric Disorder (PMDD)
The purpose of this study is to investigate the clinical efficacy of Levetiracetam in the treatment of symptoms of premenstrual dysphoric disorder (PMDD) in an open label study.
- Trial name
- pmdd (NCT00518570)
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Berkshire Health Systems
PMDD, Stress
Stress & Premenstrual Symptoms Study
This study that aims to evaluate the psychophysiology of premenstrual mood disorders (PMDs) at baseline and after treatment with sertraline. Participants will include women with PMDs and healthy female controls.
- Conditions
- PMDD, Stress, Mood
- Trial name
- NCT02777372
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dysmenorrhea Primary, Dysmenorrhea
Effect of 'Cramp Bites' on Period Cramps in Women Aged 18-25
85 percent of women of reproductive age experience consistent period cramps/menstrual pain, and 60% indicate that they do not use painkillers to relieve menstrual symptoms; there is a need for natural and non-medicative…
- Conditions
- Dysmenorrhea Primary, Dysmenorrhea, Menstrual Discomfort, Menstrual Problem
- Trial name
- NUTRITION; GYN (NCT06227676)
- Testing
- Cramp Bites by Aunt Flo's Kitchen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cornell University
Premenstrual Dysphoric Disorder
Premenstrual Hormonal and Affective State Evaluation (PHASE) Project
PHASE is designed to evaluate neuroactive hormone trajectories across the menstrual cycle and endocrine, autonomic, and subjective responses to psychosocial stress in women suffering from severe PMS (i.e., premenstrual dysphoric…
- Trial name
- PHASE Project (NCT03862469)
- Testing
- Individualized laboratory test
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Premenstrual Syndrome, Premenstrual Dysphoric Disorder
CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life
This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device…
- Conditions
- Premenstrual Syndrome, Premenstrual Dysphoric Disorder, Dysmenorrhea, Endometriosis
- Trial name
- CREST (NCT07679074)
- Testing
- Lutea Transcranial Direct Current Stimulation (tDCS) Device, Samphire Guided Care Program
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samphire Group, Inc.