Clinical trials: POTS
Postural Orthostatic Tachycardia Syndrome
CRI in POTS in Adolescents
The investigators aim to study whether the Compensatory Reserve Index (CRI) (an FDA approved device that assesses intravascular volume) can be used to evaluate severity of Postural Orthostatic Tachycardia Syndrome (POTS) and…
- Trial name
- POTS (NCT03974737)
- Testing
- CRI device (non-invasive vitals sign measurement)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Tachycardia, Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Orthostatic Intolerance
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies.
- Trial name
- NCT00608725
- Testing
- DAXOR, QSweat, Intrinsic Heart Rate
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Postural Tachycardia Syndrome
Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome
The purpose of this study is to see if people with Postural Tachycardia Syndrome (POTS) have different levels of certain chemicals in their blood than people who don't have POTS.
- Trial name
- NCT01308099
- Testing
- Blood Pressure and Blood Flow
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Dysautonomia, Anxiety
Implementation of Transdx Group for POTS
The proposed intervention is focused on developing and implementing a psychological approach incorporated into a group-based outpatient intervention for pediatric autonomic dysfunction.
- Conditions
- Dysautonomia, Anxiety, Depression
- Trial name
- NCT03185247
- Testing
- Transdiagnostic Group-Based Treatment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Postural Orthostatic Tachycardia Syndrome (POTS), POTS
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (>85%).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic Intolerance
- Trial name
- NCT03261570
- Testing
- Pyridostigmine, Digoxin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFS
Pilot-case-control study on exertion and orthostatic intolerance of adolescents with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) compared to age-matched healthy controls (HC).
- Conditions
- Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- POTS-CFS (NCT06054958)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Postural Orthostatic Tachycardia Syndrome
Dietary Salt in Postural Tachycardia Syndrome
Patients with POTS may not adequately expand their plasma volume in response to a high-sodium (Na+) diet. Mechanisms involved in the regulation of plasma volume, such as the renin-angiotensin-aldosterone system and renal…
- Trial name
- NCT01547117
- Testing
- Blood Volume, Total Blood Volume, Exercise Capacity Test - Bicycle
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postural Orthostatic Tachycardia Syndrome
Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
- Trial name
- NCT06292104
- Testing
- multimodal diagnostic testing
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postural Orthostatic Tachycardia Syndrome, Post Acute Sequelae of SARS CoV 2 Infection
NC Testing in LC & POTS
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction.
- Trial name
- NCT05914649
- Testing
- IV normal saline (999 mL infusion), IV normal saline (50 mL infusion)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Tachycardia, Chronic Orthostatic Intolerance
Treatment of Orthostatic Intolerance
This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with…
- Trial name
- NCT00262470
- Testing
- Acetazolamide, Atomoxetine, NO Drug
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Postural Orthostatic Tachycardia Syndrome, Hypocapnia
Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia
Postural tachycardia syndrome (POTS) is the most common chronic cause of postural lightheadedness, and upright confusion afflicting many Americans, mostly young women.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Hypocapnia, Hyperventilation
- Trial name
- NCT05923840
- Testing
- Chemoreflex Testing, Baroreflex testing, Orthostatic stress testing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Tachycardia Syndrome
Muscular and Cutaneous Dysfunction in POTS
POTS patients seem to experience orthostasis-dependent muscle weakness and pain as well as increased muscle fatigue upon physical activity, which can be improved by regular aerobic exercise.
- Trial name
- NCT04170725
- Testing
- Patient and Healthy Volunteers training protocol
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postural Tachycardia Syndrome
Cognitive Dysfunction in Postural Tachycardia Syndrome
A common complaint among people with Postural Tachycardia Syndrome (POTS) is "brain fog" or difficulty concentrating. This is very poorly understood.
- Trial name
- NCT01366963
- Testing
- Seated Measurements, Standing Measurements, Self-Administered Surveys
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
POTS - Postural Orthostatic Tachycardia Syndrome
RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome
RESET-POTS is a pilot study for adults with postural orthostatic tachycardia syndrome (POTS), a condition that can cause a rapid increase in heart rate, dizziness, weakness, fatigue and other symptoms when standing.
- Trial name
- RESET-POTS (NCT07837804)
- Testing
- Bilateral Sequential Stellate Ganglion Block
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
POTS - Postural Orthostatic Tachycardia Syndrome
Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?
Postural tachycardia syndrome (POTS) is a common and disabling disorder among adolescents. No epidemiologic data exist to support the often cited 0.5 to 2% prevalence.
- Trial name
- NCT06616363
- Testing
- Questionnaires to be competed, Provide list of medication and lifetime events, Use phone App to record new life events
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Postural Orthostatic Tachycardia Syndrome, Postural Tachycardia Syndrome
Autoimmune Basis for Postural Tachycardia Syndrome
The purpose of this study is to see if some people with postural tachycardia syndrome (POTS) have higher levels of immune proteins (autoantibodies) directed against receptors of the autonomic nervous system, and if these…
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Postural Tachycardia Syndrome, Tachycardia, Arrhythmias, Cardiac
- Trial name
- NCT02725060
- Testing
- phenylephrine, isoproterenol, 25 micro-Ci of radiation
- Where
- 2 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome
POTS Adrenergic Ab (CIHR Aims #1&2)
Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.
- Trial name
- NCT02673996
- Testing
- Phenylephrine, Isoproterenol
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Postural Tachycardia Syndrome
Autonomic Determinants of POTS - Pilot1
Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy young women. It is the cause of significant disability and an impairment in quality of life.
- Trial name
- NCT04050410
- Testing
- Moxonidine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center