Clinical trials: PPH
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Postpartum Hemorrhage
A Study of Self-administered Misoprostol to Prevent Bleeding After Childbirth in the Community (MamaMiso)
Postpartum hemorrhage (PPH) is a major cause of maternal death in the developing world. An important strategy in the prevention of deaths is the use of uterotonic drugs for PPH prophylaxis.
- Trial name
- NCT01510574
- Testing
- Misoprostol
- Where
- 4 sites in Uganda
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Idiopathic Pulmonary Arterial Hypertension
Virtual Reality in Patients With Pulmonary Hypertension: A Randomized Controlled Trial
The goal of this research is to investigate the effectiveness of exercise administered via immersive virtual reality in patients with pulmonary hypertension, thereby contributing to the existing literature on this subject.
- Trial name
- NCT07558460
- Testing
- Virtual Reality Group
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Postpartum Hemorrhage
Intrauterine Balloon (Bakri©) Versus Uterine Tamponade With Chitosan Gauze (Celox PPH©) in the Management of Postpartum Hemorrhage Refractory to Medical Treatmen
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, particularly in low- and middle-income countries.
- Trial name
- NCT06996808
- Testing
- Bakri Baloon, Celox gauze
- Volunteers
- 196 people
- Sponsor
- University of Roma La Sapienza
PPH - Postpartum Hemorrhage
Post-Partum Haemorrhage (PPH) Improvement of Skills With Actor Simulations
Pre test and post test questionnaire for evaluation of skills and teamwork capacities in PPH management
- Trial name
- PPH (NCT06358768)
- Testing
- teamwork job improvement overall, teamwork job improvement in actor scenario vs mannequin scenario
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- G. d'Annunzio University
Pulmonary Arterial Hypertension
A Dose Escalation Study to Evaluate the Effect of RT234 in Subjects With Pulmonary Arterial Hypertension
This multicenter, open label, Phase 2a study is designed to evaluate the effect of inhaled RT234 delivered in a dose escalation manner on the change in pulmonary vascular resistance (PVR) in subjects with Pulmonary Arterial…
- Trial name
- NCT05343637
- Testing
- Drug: RT234 - vardenafil inhalation powder; Device: RS01 dry powder inhaler (RS01 DPI)
- Where
- 3 sites in Australia
- Volunteers
- 14 people
- Sponsor
- Respira Therapeutics, Inc.
Idiopathic Pulmonary Arterial Hypertension
Features of the Clinical Course and Prognosis in Patients With Idiopathic Pulmonary Hypertension When Using Modern Strategies of Specific Therapy
This study will be performed based on a retrospective analysis of the cases of 150-170 patients with IPAH observed at the Research Institute of Clinical Cardiology over the past 10 years, for a comparative assessment of the…
- Trial name
- NCT06587074
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Russian Cardiology Research and Production Center
Hemorrhoids
TSTstarr + for Treatment of Severe Prolapsed Hemorrhoids --- a Multi-center Randomized Controlled Clinical Trail
TSTstarr+ in the treatment of severe hemorrhoids prolapse--A multi center randomized controlled clinical trial.The aim of this stuy is to compare the first year hemorrhoids recurrence rate of TSTstarr+ and PPH in the treatment of…
- Trial name
- NCT02295592
- Testing
- TSTstarr+, PPH
- Volunteers
- 780 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Postpartum Hemorrhage, Coagulation Disorder
SWIFT - SWIss Factor XIII Trial in PPH
The goal of this trial is to determine if postpartum blood loss can be reduced by replenishing coagulation factor XIII (FXIII) at an early stage of postpartum hemorrhage (PPH).
- Conditions
- Postpartum Hemorrhage, Coagulation Disorder, Coagulation Factor Deficiency, Hemorrhage
- Trial name
- SWIFT (NCT06481995)
- Testing
- Fibrogammin
- Where
- 9 sites in Switzerland
- Volunteers
- 988 people
- Sponsor
- Christian Haslinger
Postpartum Hemorrhage, Treatment Outcome
Long Term Outcome After Use of Vacuum-induced Tamponade for Postpartum Hemorrhage
This study will investigate all women treated with vacuum-induced tamponade (VIT) for PPH at a tertiary center, namely at the University Hospital Zurich (USZ), over a nine-year period (2017-2025).
- Conditions
- Postpartum Hemorrhage, Treatment Outcome, Pregnancy Outcome
- Trial name
- LOVIT (NCT07885072)
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University of Zurich
Lung Diseases, Hypertension, Pulmonary
Genetic and Environmental Characteristics of Primary Pulmonary Hypertension
The goal of this study is to identify the modifying genes and environmental features that regulate the clinical expression of mutations in bone morphogenetic protein receptor 2 (BMPR2); to develop the understanding of how BMPR2…
- Trial name
- NCT00091546
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Vanderbilt University
Pulmonary Arterial Hypertension
Hemodynamic Evaluation of Dose-response and Safety of Dry Powder Inhalation of Treprostinil
Acute and chronic hemodynamic dose-response and safety evaluation of LIQ861 in PAH subjects.
- Trial name
- NCT03884465
- Testing
- Inhaled dry powder treprostinil (LIQ861)
- Where
- 3 sites in France, Germany
- Volunteers
- 15 people
- Sponsor
- Liquidia Technologies, Inc.
High Risk Postpartum Hemorrhage (PPH)
ROTEM® Obstetric Hemorrhage Pilot Study
This is a prospective observational study among women at high-risk of postpartum hemorrhage, in their third trimester who are admitted to Labor \&Delivery in spontaneous labor, for induction of labor, or for scheduled cesarean…
- Trial name
- NCT04409015
- Testing
- ROTEM - rotation thromboelastometry testing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Postpartum Hemorrhage
Comparing Misoprostol and Oxytocin in UnijectTM for Postpartum Hemorrhage (PPH) Prevention in Mali
This is a large, community-based, cluster-randomized trial to compare routine prophylactic use of 600 mcg oral misoprostol and 10 IU oxytocin delivered by UnijectTM intramuscularly during the third stage of labor.
- Trial name
- NCT01487278
- Testing
- misprostol, UnijectTM
- Where
- Mali
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pulmonary Artery Hypertension
Vascular Subphenotypes of Lung Disease in HIV & COPD
This study is looking for high blood pressure in the lungs (Pulmonary artery hypertension PAH) in HIV and COPD patients.
- Trial name
- VAST (NCT01581086)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Idiopathic Pulmonary Arterial Hypertension
Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension
Experimental data suggest that transplantation of endothelial progenitor cells (EPCs) attenuates monocrotaline-induced pulmonary hypertension in rats and dogs.
- Trial name
- NCT00372346
- Testing
- Transplantation of autologous endothelial progenitor cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhejiang University
Hypertension, Pulmonary
Safety of Terbogrel in Patients With Primary Pulmonary Hypertension
Study to assess the safety of terbogrel during open-label, long-term treatment in medically stable or improving patients with primary pulmonary hypertension who have completed the 12-week, double-blind randomized trial of…
- Trial name
- NCT02223494
- Testing
- Terbogrel
- Volunteers
- 33 people
- Sponsor
- Boehringer Ingelheim
Primary Myelofibrosis, Primary Pulmonary Hypertension
Reversible Secondary Myelofibrosis or Clonal Myeloproliferative Disorder
To determine the prevalence of myelofibrosis in patients with primary pulmonary hypertension, and to discover if the fibrosis in these patients is primary (AMM) or secondary.
- Conditions
- Primary Myelofibrosis, Primary Pulmonary Hypertension, Secondary Myelofibrosis, Pulmonary Arterial Hypertension
- Trial name
- NCT00722254
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Postpartum Hemorrhage
Routine Bilateral Uterine Artery Ligation During the Cesarean Delivery of Multiple Gestation
Multiple pregnancy is well defined to be associated with a greater risk of postpartum blood loss . Interventions to control PPH generally stepped from less to more invasive and including compression maneuvers , drugs , and…
- Trial name
- NCT05670886
- Testing
- uterine artery ligation
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Postpartum Hemorrhage
Evaluating the Safety and Efficacy of RUCS in PPH
This retrospective observational study aims to evaluate the efficacy and safety of Removable Uterine Compression Sutures (RUCS) in the surgical management of postpartum hemorrhage (PPH).
- Trial name
- RUCS-PPH (NCT07115355)
- Testing
- Removable Uterine Compression Suture (RUCS)
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Havva Betül Bacak