Clinical trials: PPOS
Polycystic Ovary Syndrome (PCOS), Female Infertility
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
- Trial name
- PPOS-PCOS-IVF (NCT07394530)
- Testing
- Progestin-Primed Ovarian Stimulation (PPOS), GnRH Antagonist Protocol
- Where
- Vietnam
- Volunteers
- 400 people
- Sponsor
- Hanoi General Hospital (Vietnam)
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
225 IU Versus 300 IU Starting FSH Dose in PPOS for Good-Prognosis Women
This randomized controlled trial will compare two starting doses of follicle-stimulating hormone (FSH), 225 IU and 300 IU, during progestin-primed ovarian stimulation (PPOS) in women undergoing in vitro fertilization (IVF) who…
- Trial name
- FSH-PPOS (NCT07772375)
- Testing
- Follitropin Alfa (Follitrope)
- Where
- Vietnam
- Volunteers
- 380 people
- Sponsor
- Vietnam Military Medical University
IVF, PCO
Progesterone Primed Protocol Versus GnRH Antagonist in With PCO Undergoing ICSI
To compare the effectiveness and safety of Progesterone Primed Ovarian Stimulation protocol (PPOS) using Dydrogestrone vs GnRH Antagonist Protocol in patients with expected high ovarian response undergoing ICSI cycle
- Trial name
- NCT05951400
- Testing
- Dydrogesterone Tablets, Cetrorelix
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Ovarian Stimulation, Quality of Life
PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study
P-CCROSS is a randomized, prospective monocentric phase 4 study with a crossover study design. The aim of the study is to compare patient satisfaction (by means of questionnaires) and treatment compliance with IVF treatment with…
- Conditions
- Ovarian Stimulation, Quality of Life, Preimplantation Genetic Testing, Fertility Preservation
- Trial name
- P-CCROSS (NCT06175832)
- Testing
- Elonva®, Puregon®, Orgalutran®
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Progestins Primed Ovarian Stimulation
PPOS vs GnRH Antagonist in Ovarian Stimulation (ProGanOS Study)
This non-inferiority randomized controlled trial will be conducted at My Duc Hospital, Ho Chi Minh City, Vietnam. This study compares the effectiveness of Progestin-Primed Ovarian stimulation versus GnRH protocol for ovarian…
- Trial name
- ProGanOS (NCT06378268)
- Testing
- Dydrogesterone 10 mg, Cetrorelix 0.25 mg
- Where
- Vietnam
- Volunteers
- 626 people
- Sponsor
- Mỹ Đức Hospital
PPOS, GnRH Antagonist
PPOS Protocol Versus GnRH Anatagonist for Expected Normal Responder Patients Undergoing ART : a Randomized Clinical Trial
The aim of this study is to compare the efficacy and safety of Progestin-Primed Ovarian Stimulation (PPOS) protocol versus the fixed GnRH antagonist protocol in expected normal responder patients undergoing intracytoplasmic sperm…
- Conditions
- PPOS, GnRH Antagonist, Assisted Reproductive Techniques
- Trial name
- PPOS vs GnRH (NCT06868576)
- Testing
- Dydrogesterone Oral Tablet, Cetrorelix (Cetrotide)
- Where
- Egypt
- Volunteers
- 328 people
- Sponsor
- Kasr El Aini Hospital
Infertility, ART
Comparison of the Live Birth Rate Between the PPOS and the GnRH Antagonist Protocol in Patients Undergoing IVF
A randomized comparison of the live birth rate between the progestin-primed ovarian stimulation protocol and the gonadotrophin releasing hormone antagonist protocol in patients undergoing in vitro fertilization Research question…
- Trial name
- NCT03680053
- Testing
- Duphaston, Cetrorelix
- Where
- China
- Volunteers
- 220 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
PCOS (Polycystic Ovary Syndrome)
Can Drospirenone be Used to Prevent LH Surge in Controlled Ovarian Stimulation in PCOS?!
The goal of this clinical trial is to learn if drospirenone can work to prevent LH surge in controlled ovarian stimulation in PCOS cases undergoing ART cycles.
- Trial name
- PPOS (NCT06608186)
- Testing
- Cetrorelix drug, Drospirenone drug
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ahmed Saad
Infertility (IVF Patients)
An Advanced Decision Support Tool for Personalized Medicine for IVF Using Modeling and Optimization for Provera
A clinical trial will determine the effectiveness of using the Opt-IVF decision support tool for each patient's personalized and optimal drug dosage profile in the United States.
- Trial name
- NCT07148999
- Testing
- Opt-IVF, Control
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Urmila DIwekar
InVitro Fertilization, Gonadotropins
rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study
This study aims to compare two commonly used hormone treatments for women undergoing IVF. All participants will receive a stimulation protocol that includes dydrogesterone, a medication used to safely control natural hormone…
- Trial name
- DYG-GONA (NCT07348757)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Centrum Clinic IVF Center
IVF, GnRH Antagonist
Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
Progestin can inhibit the pituitary LH surge during ovarian stimulation and various studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF.
- Conditions
- IVF, GnRH Antagonist, PPOS
- Trial name
- NCT04414761
- Testing
- Progesterone, GnRH Antagonist
- Where
- China
- Volunteers
- 784 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Stimulation in the Ovary, Embryo
Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A.
The PPOS protocol (Progestin-primed Ovarian Stimulation) involves avoiding ovulation during ovarian stimulation with progesterone.
- Conditions
- Stimulation in the Ovary, Embryo, Oocyte, Oocyte Retrieval
- Trial name
- PPDUO (NCT06637189)
- Testing
- Ganirelix, Medroxyprogesterone Acetate 10 MG
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ginefiv
IVF, Infertility
Desogestrel Versus GnRH Antagonist in IVF/ICSI
Progestin primed ovarian stimulation (PPOS) has been shown to be effective in avoiding premature spontaneous ovulation, without affecting the number of retrieved oocytes or the quality of the embryos obtained.
- Trial name
- DEGOS (NCT04728659)
- Testing
- Desogestrel 0.075 MG, Orgalutran
- Where
- Italy
- Volunteers
- 165 people
- Sponsor
- Casa di Cura Privata Villa Mafalda
Poor Ovarian Reserve, Infertility (IVF Patients)
Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI
Participants will: Take either drospirenone (a daily pill) or the standard daily injection during their ovarian stimulation cycle, alongside their regular fertility hormone injections Undergo egg retrieval, with all resulting…
- Trial name
- PPOS (NCT07736261)
- Testing
- Drospirenone drug, Cetrorelix 0.25 mg
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmed Saad
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS and GnRH antagonist protocols in patients undergoing PGT-A.
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Euploid Rate, GnRH Antagonist
- Trial name
- NCT04414748
- Testing
- GnRH antagonist, oral Duphaston
- Where
- China
- Volunteers
- 400 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Ivf
Opt-IVF for Personalized Medicine for Normal Responders
A clinical trial will determine the effectiveness of the Opt-IVF decision-support tool in generating personalized, optimal drug-dosage profiles for each patient in the United States.
- Trial name
- NCT07856082
- Testing
- Opt-IVF, control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Urmila DIwekar
Prescriptions, Elderly (people Aged 65 or More)
Inappropriate Prescribing in the Elderly
The management of pharmacotherapy in elderly patients is an increasingly critical aspect, as polypharmacy, combined with the pharmacokinetic and pharmacodynamic changes typical of aging, makes older adults more sensitive to the…
- Conditions
- Prescriptions, Elderly (people Aged 65 or More), Hospitalized, Prevalence
- Trial name
- STOPP&START (NCT06760728)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana
Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation
Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Women With PCOS Undergoing PGT-A
This randomized trial aims to compare the euploid rate of blastocysts between PPOS (progestin-primed ovarian stimulation) and GnRH (gonadotrophin releasing hormone) antagonist protocols in patients with PCOS (polycystic ovary…
- Conditions
- Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Polycystic Ovarian Syndrome, GnRH Antagonist
- Trial name
- NCT05326087
- Testing
- GnRH antagonist, MPA
- Volunteers
- 204 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility, Female, Fertility Disorders
Comparison of Two PPOS Models for Pituitary Suppression
The scarcity of evidence regarding the interchangeable use of different progestogens poses challenges, particularly in international egg donation and fertility preservation programs where standardizing protocols is crucial for…
- Trial name
- NCT06304220
- Testing
- Cerazet
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- NextFertility
Infertility (IVF Patients), Embryo Morphokinetics
IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol.
- Conditions
- Infertility (IVF Patients), Embryo Morphokinetics, Progestins Primed Ovarian Stimulation
- Trial name
- NCT07409493
- Testing
- Progestin-Primed Ovarian Stimulation, Antagonist protocol for IVF
- Where
- Vietnam
- Volunteers
- 148 people
- Sponsor
- Hanoi Medical University