Clinical trials: PPROM
Preterm Rupture of Membranes
Trace Elements and Heavy Metals at PPROM
Objectives: To evaluate maternal serum trace elements and heavy metals namely, aluminum (Al), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), molybdenum (Mo), cadmium (Cd), tin (Sn)…
- Trial name
- metals&PROM (NCT04077944)
- Testing
- maternal serum concentration of trace elements and heavy metals levels
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after…
- Conditions
- Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth
- Trial name
- NCT04047849
- Testing
- Antibiotics, oral Azithromycin and oral Amoxicillin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Woman's
Preterm Premature Rupture of Membranes
Matrix Metalloproteinase 14, Neopterin, and Orosomucoid 1 Levels in PPROM
Introduction: To evaluate the maternal blood serum matrix metalloproteinase 14, neopterin, and orosomucoid 1 levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to compare the results with…
- Trial name
- MMP-14&PPROM (NCT04532021)
- Testing
- matrix metalloproteinase 14, neopterin, and orosomucoid 1 measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Preterm Premature Rupture of Membranes
Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM)
The purpose of this study is to determine if the short term use of indomethacin will reduce the number of women delivering within 48 hours when given to women with preterm premature rupture of membranes (PPROM) between 24- 32…
- Trial name
- NCT00466128
- Testing
- indomethacin
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pregnancy, Premature Rupture of Membranes
Cervical Ripening in Premature Rupture of Membranes
Premature rupture of membranes (PROM) is diagnosed by demonstrating amniotic fluid in the vaginal canal before the onset of labor.
- Conditions
- Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable Cervix
- Trial name
- NCT02314728
- Testing
- Misoprostol, Oxytocin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Preterm Premature Rupture of Membranes
Magnesium Sulfate Versus Placebo for Tocolysis in PPROM
Study compares the outcomes of women between 26 and 32 wks gestation with rupture of membranes. Women randomized to receive tocolysis with magnesium sulfate x 48 hrs or placebo of saline IV x 48 hrs.
- Trial name
- NCT00463736
- Testing
- Magnesium sulfate
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Regional Obstetrical Consultants
Preterm Premature Rupture of Membrane
Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes
Randomized controlled trial studying the use of vaginal cleansing with chlorhexidine gluconate for pregnant women with PPROM (preterm pre labor rupture of membranes). The primary outcome will be pregnancy latency.
- Trial name
- NCT04516226
- Testing
- Vaginal cleansing with chlorhexidine gluconate solution
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Preterm Birth, Preterm Premature Rupture of Membrane
Amniochorionic Membrane Cells in the Maternal Blood as a Biomarker for Preterm Birth
Globally, preterm birth (15 mill. per year) is the leading cause of under-5 child mortality (1 mill. per year) and morbidity. Important pathways include preterm labor contractions, Preterm Prelabor Rupture of the Fetal Membranes…
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Labor
- Trial name
- NCT04705935
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Preterm Premature Rupture of Membrane, Placenta Diseases
Biochemical and Histological Changes in Pregnant Women With Preterm Premature Rupture of Membrane
Although preterm premature rupture of membranes (PPROM) is one of the most common causes of preterm birth, it can also lead to serious maternal and neonatal complications.
- Trial name
- NCT06639919
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Fetal Membranes, Premature Rupture
Myometrial Thickness as a Predictor for the Latency Interval in PPROM
100 women divided into 3 groups: Group I: included 50 women with preterm premature rupture of membranes (PPROM, n=50) with gestational age from 24 to 34 weeks.
- Trial name
- NCT02380560
- Testing
- Ultrasonographic examination
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Preterm Premature Rupture of Membranes, Pregnant State
Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes
In this study the investigators sought to determine the effects of Pomegranate (Natural pomegranate polyphenol (P. granatum L) extract) : 1. On the maternal and fetal oxidative stress and inflammation associated with PPROM. 2.
- Trial name
- NCT01584323
- Testing
- Pomgranate pills
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Pathology of Pregnancy
Maternal Plasmatic Regulatory T Cells and Th17 as Possible Diagnosis Markers of Acute Chorioamnionitis
The purpose of this study is to evaluate if regulator T cells (Treg) and Th17 level modifications in maternal blood and placenta could be correlated to a chorioamnionitis, in women hospitalized for PPROM.
- Trial name
- ICAR (NCT01610258)
- Testing
- Blood and placenta samples
- Where
- 2 sites in France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Preterm Labor
Uterocervical Angle in Patients With Preterm Premature Rupture of the Membranes
To evaluate the performance of uterocervical angle (UCA) in the prediction of labor timing in patients with preterm premature rupture of the membranes
- Trial name
- NCT04095507
- Testing
- uterocervical angle
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nefise Nazlı YENIGUL
Vaginal Infections, Bacterial Vaginosis
Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery
The purpose of this study is to determine whether screening of pregnant women with history of previous preterm delivery, once a week, for bacterial vaginosis using VA-SENSE, and treatment of positive women will reduce the risk of…
- Conditions
- Vaginal Infections, Bacterial Vaginosis, Late Miscarriage, Preterm Birth
- Trial name
- NCT01152528
- Testing
- VA-SENSE
- Where
- Israel
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Common Sense
Preterm Premature Rupture of Membrane
Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes
The aim of the study is to assess the efficacy of 17-hydroxyprogesterone caproate (17P) therapy on the latency period in pregnant women with Preterm premature rupture of membranes.
- Trial name
- NCT04807543
- Testing
- 17-hydroxyprogesterone caproate, Castor Oil
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
PPROM, Respiratory Distress Syndrome in Premature Infants
Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?
The purpose of this study is to determine if a repeat course of betamethasone given to pregnant women with preterm premature rupture of membranes (PPROM) will decrease the infant's length of stay in the neonatal intensive care…
- Trial name
- NCT02939742
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Preterm Premature Rupture of the Membranes
Transperineal Ultrasonography and Premature Rupture of Membranes
This study's aim is to evaluate diagnostic accuracy of transperineal ultrasound assessment compared with speculum examination, nitrazine and placental micro globulin-1 tests.
- Trial name
- NCT02386644
- Testing
- PAMG-1 Immunoassay, Ultrasound transperineal assessment, Ultrasound amniotic fluid index measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Ankara University
Preterm Premature Rupture of Membrane
Predictive Value of Maternal Serum Pentraxin 3 (PTX 3) and Heparin-binding Protein (HBP) for Chorioamnionitis in Preterm Premature Rupture of Membranes
Objective: The aim of this study was to investigate the predictive value of maternal serum pentraxin 3 (PTX3) and heparin-binding protein (HBP) for chorioamnionitis in preterm premature rupture of membranes (PPROM).
- Trial name
- NCT05207800
- Testing
- The concentrations of PTX3 and HBP were monitored in maternal blood, placental tissue and amniotic fluid.
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Preterm Birth, Preterm Premature Rupture of Membrane
Cerclage After Full Dilatation Caesarean Section
CRAFT-OBS: Observational Study; To evaluate subsequent pregnancy risk of preterm birth in women with a history of previous caesarean in established labour.
- Conditions
- Preterm Birth, Preterm Premature Rupture of Membrane, Preterm Spontaneous Labor With Preterm Delivery
- Trial name
- CRAFT (NCT04110704)
- Testing
- Insertion of transvaginal cerclage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Preterm Rupture of Membranes
Identification of Microbial DNA in Maternal Plasma After PPROM
This study evaluates the use of metagenomic next generation sequencing in identifying microbial DNA in plasma samples of patients with preterm premature rupture of membranes.
- Trial name
- NCT04318470
- Testing
- mNGS
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco