Clinical trials: PREG1
Hypertension, Pregnancy
Exercise in Pregnancy for Reduction of Blood Pressure in Obese Patients
Preeclampsia and other high blood pressure disorders of pregnancy are a significant cause of both maternal and fetal complications of pregnancy.
- Conditions
- Hypertension, Pregnancy, Preeclampsia, Exercise
- Trial name
- NCT01261884
- Testing
- Exercise support, Exercise intervention
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Gestational Hypertension, Preeclampsia
B Vitamin Deficiency and Pregnancy Complications
This case-control study aims to investigate the association between B vitamins and gestational hypertension or preeclampsia.
- Trial name
- NCT05720650
- Testing
- No intervention
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Pregnancy Related, Pre-Eclampsia
Natural Versus Programmed Frozen Embryo Transfer (NatPro)
NatPro is a two-arm, parallel-group, multi-center, randomized trial in which women undergoing frozen embryo transfer (FET) will be randomized to receive either a modified natural cycle (corpus luteum present) or a programmed…
- Trial name
- NatPro (NCT04551807)
- Testing
- Modified natural cycle, Programmed cycle
- Where
- 15 sites in United States
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- JHSPH Center for Clinical Trials
Preeclampsia, Preterm Birth
Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications
The Biobank includes data and biological specimens of women from three original studies: 1) First-trimester Prediction of Preeclampsia (PREDICTION Study, NCT02189148), 2) Pre-Eclampsia And growth Retardation, an evaluative…
- Conditions
- Preeclampsia, Preterm Birth, Pregnancy Complications, Fetal Anomalies
- Trial name
- NCT02744365
- Testing
- Observational
- Where
- Canada
- Volunteers
- 7,845 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Preeclampsia, Stress, Psychological
Stress Reduction in Formerly Preeclamptic Women; Sofa or Sports
The goal of this clinical trial is to evaluate stress and cardiovascular risk factors in women with preeclampsia in the medical history.
- Conditions
- Preeclampsia, Stress, Psychological, Stress, Physiological, Sports Physical Therapy
- Trial name
- SOS (NCT06402604)
- Testing
- Aerobic exercise training, Mindfulness Based Stress Reduction training
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Apnea, Obstructive Sleep, Pregnancy Complications
Sleep Apnea Syndrome in Obese Women During Pregnancy
Excess weight or obesity is associated with an increased risk of health disorders: high blood pressure, diabetes, cardiovascular risks, dyslipidemia and sleep apneas.
- Conditions
- Apnea, Obstructive Sleep, Pregnancy Complications, Pre-Eclampsia, Obesity
- Trial name
- NCT03509805
- Testing
- polysomnography
- Where
- France
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Preeclampsia, Placenta Diseases
Investigating CD 71 in Preeclamptic Pregnancies
Objective: Upon reviewing studies aimed at understanding and investigating the pathogenesis of preeclampsia, it has been observed that CD71 has not been previously examined.
- Trial name
- NCT06668545
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Preeclampsia, Eclampsia
RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil
The perinatal morbidity and mortality rates for Brazil are five to ten-fold higher than those reported for upper income countries.
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Pregnancy
- Trial name
- NCT00097110
- Testing
- Vitamin C and E
- Where
- Brazil
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Pre-Eclampsia
Management of Suspected Preeclampsia Based on 6-hour Versus 24-hour Urine Protein Collection
In this trial - the investigators plan to study the efficacy of pregnancy management in cases of suspcted preeclampsia, based on a 6-hour urine collection for protein, as compared to the standard 24-hour collection.
- Trial name
- NCT03724786
- Testing
- Six-hour urine protein collection
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Preeclampsia (PE) Risk
An Interventional Pilot Study on the Effect of Extra Virgin Olive Oil on Women with Preeclampsia Risk
This study explores the potential benefits of Extra Virgin Olive Oil from early harvested olives (EVOOEH) in reducing the risk of preeclampsia (PE) in high-risk pregnant women.
- Trial name
- NCT06759545
- Testing
- Dietary MOH recommendations and daily addition of 42 ml (three tablespoon) at each morning of EVOOEH, Dietary MOH recommendations
- Where
- Israel
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Yaniv Ovadia
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Preeclampsia
Cardiovascular Risk After Preeclampsia
Investigation of cardiovascular risk 5-15 years after early or late-onset preeclampsia by adenosine stress Magnetic Resonance Imaging and non-invasive methods like retinal vessel analysis, skin measurement of advanced glycation…
- Trial name
- NCT05277233
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
PREG1
Effects of Carbetocin and Oxytocin Used in Cesarean Sections on Postoperative Pain
The aim of this observational study is to compare postoperative analgesic consumption in patients who received peroperative carbetocin or oxytocin. The main question it aims to answer is: .
- Trial name
- NCT06692621
- Testing
- Oxytocin, Carbetocin
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Pre-Eclampsia
First Trimester Screening for Preeclampsia and Intrauterine Growth RestrIction Using Three Dimensional Doppler Angiography
Introduction: Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two major pregnancy complications, related to a chronic utero-placental hypoperfusion.
- Trial name
- SPIRIT (NCT03342014)
- Testing
- Ultrasound, Blood sample collection
- Where
- France
- Volunteers
- 2,159 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Pregnancy Complications, Ultrasound Therapy; Complications
Lung Ultrasound Patterns Preeclampsia
Evaluation of lung ultrasound as a diagnostic tool in pregnant patients.
- Conditions
- Pregnancy Complications, Ultrasound Therapy; Complications, Pulmonary Disease, Pulmonary Edema
- Trial name
- NCT03576092
- Testing
- Lung Ultrasound
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pre-Eclampsia, Vascular Diseases
Mechanisms of Pregnancy Vascular Adaptations
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples…
- Trial name
- NCT03806283
- Testing
- Omental Biopsy
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Preeclampsia, Hypertension
CPAP in Preeclampsia
Study design: Single blinded randomised control trial Planned sample size: 30 (women randomized 2:1 to receive either CPAP or no CPAP) Objectives: Primary objective: Assess the effects of nasal CPAP on sleep physiology, 24 blood…
- Trial name
- NCT02303834
- Testing
- Continuous Positive Airway Pressure Ventilation (CPAP)
- Where
- 2 sites in Australia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Pre-Eclampsia
CA-125 and Severity of Pre-Eclampsia
The Aim of this study is to determine the relationship between serum concentrations of cancer antigen-125 (CA-125) and pre-eclampsia severity.
- Trial name
- NCT02704676
- Testing
- marker(CA-125)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Preeclampsia, Pregnancy Complications
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to take place.
- Conditions
- Preeclampsia, Pregnancy Complications, Insemination; Complication, Immune Tolerance
- Trial name
- NCT04314518
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center