Clinical trials: PREG1, open to volunteers
Pregnancy, Preeclampsia
Effects of Progressive Muscle Relaxation Exercise and Finger Grip Exercise on Stress, Anxiety, Fatigue, Sleep Quality, and Physiological Parameters in Pregnant Women With Preeclampsia
The aim of this study is to examine the effects of progressive muscle relaxation exercise and finger grip exercise on stress, anxiety, sleep quality, fatigue and physiological parameters in preeclamptic pregnant women.
- Trial name
- NCT07630623
- Testing
- Progressive Muscle Relaxation Exercise, Finger Grip Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hatice Nur Nefes Pala
Preeclampsia (PE) Risk, Preeclampsia
Hyperspectral Imaging for Prediction of Preeclampsia
Preeclampsia is a hypertensive pregnancy disorder that can quickly lead to serious, potentially life-threatening outcomes for both the mother and the fetus.
- Trial name
- HIPPA (NCT07106294)
- Where
- Germany
- Volunteers
- 1,430 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Preeclampsia, Intrauterine Growth Restriction
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Preeclampsia (PE) affects ~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome
- Trial name
- PE37 (NCT04766866)
- Testing
- sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
- Where
- 21 sites in Belgium, Colombia and 7 more
- Volunteers
- 9,132 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pregnancy, Pre-eclampsia
LimPrOn: Limburg Pre-eclampsia Investigation
Background: Multiple adaptations at the cardiovascular system occurs during pregnancy. In the pregnancy condition pre-eclampsia (PE), this adaptations are abnormal.
- Trial name
- LimPrOn (NCT03509272)
- Testing
- remote monitoring
- Where
- 8 sites in Belgium
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Preeclampsia (PE)
Prevention of Preeclampsia in Denmark: A National Implementation Study
The goal of this clinical study is to learn if a new first-trimester screening program can better find pregnant women who are at high risk of developing preeclampsia and help prevent the condition with early treatment.
- Trial name
- PREPRED (NCT07485140)
- Testing
- First trimester screening for preeclampsia
- Where
- 3 sites in Denmark
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Fetal Growth Restriction (FGR), Preterm Birth
Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and Innovation
Pregnancy complications such as pre-eclampsia (high blood pressure during pregnancy), poor fetal growth, unexplained stillbirth, and spontaneous preterm birth are major causes of illness and death for mothers and babies in…
- Conditions
- Fetal Growth Restriction (FGR), Preterm Birth, Still Births, Abruptio Placentae
- Trial name
- EPAPOA (NCT07844876)
- Where
- 2 sites in Uganda
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Preeclampsia
Exosome Cargo From Preeclampsia Patients
Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia.
- Trial name
- NCT04154332
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Preeclampsia Awarness
Improve Awarness of Preeclampsia Among Pregnant Women
Preeclampsia is a major pregnancy-related hypertensive disorder and a leading cause of maternal and perinatal morbidity and mortality worldwide, particularly in developing regions.
- Trial name
- NCT07805239
- Testing
- Questionnaire
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Aya Magdy Mohamed Amin
Monitoring Blood Pressure, Aspirin Prophylaxis
Improving Prenatal Care to Reduce Early Onset Preeclampsia in Low-Income
The goal of this clinical trial is to learn if a telehealth hypertension group prenatal care program (Centering HER / HGPC-T) can improve blood pressure monitoring and aspirin adherence and help reduce early-onset preeclampsia in…
- Trial name
- NCT07491510
- Testing
- Active Comparator: Behavioral: Experimental: Centering HER (routine prenatal care + 7 doula-led 90-minute virtual group
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Pre-Eclampsia, HELLP Syndrome
PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis
Pregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life.
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Intrauterine Growth Restriction, Pregnancy
- Trial name
- PEARLS (NCT05500989)
- Where
- Netherlands
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pregnancy Related, Remote Monitoring
Feasibility of Remote eCTG Monitoring Home@Hospital in Complicated Pregnancies
The objective of this single center, interventional cohort study is to evaluate the feasibility of remote electrophysiological cardiotocography (eCTG) monitoring in complicated pregnancies in a home@hospital setting.
- Conditions
- Pregnancy Related, Remote Monitoring, Feasibility
- Trial name
- HASTA (NCT06859177)
- Testing
- Remote eCTG
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Pre-Eclampsia
At High-risk for Pre-eclampsia After Assisted Reproductive Technology
The overarching goal of the project is to unravel PE etiopathogenesis in high-risk patients (PCOS patients and oocyte acceptors) after assisted reproductive technology (ART) to individualize prenatal care following ART and to…
- Trial name
- HEART (NCT05746793)
- Testing
- endometrium biopsy, Transabdominal ultrasound, Peripheral phlebotomy
- Where
- Belgium
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Preeclampsia, Endothelial Function
Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia
Preeclampsia is a condition in pregnancy where a woman develops high blood pressure and other complications. Women who develop preeclampsia are 4 times more likely to have heart disease later in life.
- Trial name
- NCT07715669
- Testing
- Paroxetine Hydrochloride, Ascorbic acid (Vitamin C)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Preeclampsia Postpartum
Postpartum Low-Dose Aspirin and Preeclampsia
The purpose of this research study is to find out whether women with severe preeclampsia taking low-dose aspirin (LDA) for 3 weeks post-delivery will experience an improvement in endothelial function (measured as flow-mediated…
- Trial name
- NCT03667326
- Testing
- Aspirin tablet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pregnant Women With Singleton Pregnancies
Harvesting Health: Advancing Nutrition and Wellness for Moms and Babies
This is a randomized controlled trial to assess whether a personalized food kit to pregnant women is feasible, improves diet quality, and enhances pregnancy and birth outcomes compared to standard prenatal care.
- Trial name
- HH (NCT07659821)
- Testing
- Food Kit
- Where
- 3 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Preeclampsia, Preeclampsia Postpartum
Vascular Effects of High-Salt After Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT06749418
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Pregnancy, IUGR
Effects of High Altitude on AMPK Activation
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE).
- Conditions
- Pregnancy, IUGR, Preeclampsia
- Trial name
- NCT02391519
- Testing
- Collection of myometrial, cord blood, and placental tissue samples
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pre-eclampsia, Gestational Diabetes Mellitus (GDM)
Placental Biology in Health and Disease
Pre-eclampsia (PET) is a condition characterised by high blood pressure and damage to other organs, and is a leading cause of maternal and fetal complications such as fetal growth restriction (FGR).
- Conditions
- Pre-eclampsia, Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), Pregnancy Induced Hypertension (PIH)
- Trial name
- NCT07470320
- Testing
- There are no interventions for this study
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pre-Eclampsia, Vascular Diseases
Mechanisms of Pregnancy Vascular Adaptations
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples…
- Trial name
- NCT03806283
- Testing
- Omental Biopsy
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pre-Eclampsia, Severe, Pregnancy
Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia
The goal of this observational study is to determine whether noninvasive finger plethysmographic cardiac output monitoring can help predict fluid responsiveness in pregnant women, including those with preeclampsia with severe…
- Trial name
- NCT07430254
- Testing
- Noninvasive finger plethysmographic cardiac output monitoring, Standard transthoracic echocardiographic assessment
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Stanford University