Clinical trials: PROM
Preterm Premature Rupture of the Membranes
Transperineal Ultrasonography and Premature Rupture of Membranes
This study's aim is to evaluate diagnostic accuracy of transperineal ultrasound assessment compared with speculum examination, nitrazine and placental micro globulin-1 tests.
- Trial name
- NCT02386644
- Testing
- PAMG-1 Immunoassay, Ultrasound transperineal assessment, Ultrasound amniotic fluid index measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Ankara University
Management of Women With PROM at Term
Hospital Admission Versus Home Management in Women With Premature Rupture of Membranes :RCT
According to high tendency for admission of cases of premature rupture of membranes (PROM) for fear of maternal \& fetal complications, we compare here between cases managed at hospital with other managed at home for if there any…
- Trial name
- NCT03435263
- Testing
- home management
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Perimenopause, Menopause
CARAMEL Observational Study
CARAMEL is a project funded by the European Commission under the Horizon Europe programme. Its aim is to develop a personalized prevention approach based on state-of-the-art artificial intelligence models for cardiovascular risk…
- Conditions
- Perimenopause, Menopause, Cardiovascular (CV) Risk, Women (Between 30 to 60 Years Old)
- Trial name
- CARAMEL-OS (NCT07695376)
- Where
- 6 sites in Colombia, Croatia and 3 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
PPROM, Respiratory Distress Syndrome in Premature Infants
Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?
The purpose of this study is to determine if a repeat course of betamethasone given to pregnant women with preterm premature rupture of membranes (PPROM) will decrease the infant's length of stay in the neonatal intensive care…
- Trial name
- NCT02939742
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Preterm Premature Rupture of Fetal Membranes
Core-temperature Monitoring in Patients With PPROM
The most common reason for preterm prelabor rupture of membrane (PPROM) is an ascendance of infection. Moreover PPROM is one of the main risk factors for chorioamnionitis.
- Trial name
- NCT02125708
- Testing
- OvulaRing®
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Preterm Premature Rupture of Fetal Membranes, Induction of Labor Affected Fetus / Newborn
A Randomized Trial of Induction Methods in Premature Rupture of Membranes
This study evaluates the addition of transcervical Foley catheter balloon and vaginal prostaglandin E2 induction in premature rupture of membranes.
- Trial name
- NCT03744078
- Testing
- Foley balloon catheter
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Pregnancy, Prelabor Rupture of Membranes
Safety Study of Membrane Sweeping in Pregnancy
The purpose of this study is to determine if routine membrane sweeping in uncomplicated term pregnancies increases the rate of pre-labor rupture of membranes.
- Trial name
- NCT00294242
- Testing
- Membrane Sweep, No Membrane Sweep
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tripler Army Medical Center
Preterm Rupture of Membranes
Trace Elements and Heavy Metals at PPROM
Objectives: To evaluate maternal serum trace elements and heavy metals namely, aluminum (Al), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), molybdenum (Mo), cadmium (Cd), tin (Sn)…
- Trial name
- metals&PROM (NCT04077944)
- Testing
- maternal serum concentration of trace elements and heavy metals levels
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Chorioamnionitis, Placenta Diseases
Effect of Chorioamnionitis on Platelet Activation and Placental Vessel Among Preterm Infants by Wnt-Flt1 Signal Pathway
Objective:The purpose of this study was to explore the effect and mechanism of maternal chorioamnionitis on placental microvasculature and platelet activation among preterm infants by activating Wnt-Flt1 signal pathway .
- Conditions
- Chorioamnionitis, Placenta Diseases, Thrombocytopenia, Preterm Infant
- Trial name
- NCT03636698
- Testing
- chorioamnionitis
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Premature Rupture of Fetal Membranes
Does Nipple Stimulation Shorten Time to Vaginal Birth in Women With Term PROM?
Premature Rupture of Membranes (PROM) is defined as the rupture of membranes before the onset of regular uterine contractions. PROM occurs in approximately 10% of all pregnancies (ranging from 2.7% to 17%), with 60% to 80% of…
- Trial name
- NIPROM (NCT03025581)
- Testing
- Nipple stimulation
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Preterm Delivery
Progesterone (17P, Makena®) for Prolongation of Pregnancy in Women With Preterm Rupture of the Membranes (PROM)
The objective of the study is to determine if a weekly dose of 17 hydroxyprogesterone caproate (17P, Makena®) given to women with preterm rupture of the membranes will: 1.
- Trial name
- 17PinPROM (NCT01119963)
- Testing
- 17-alpha-hydroxy-progesterone caproate, Makena®
- Where
- 15 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Obstetrix Medical Group
Preterm Birth, Preterm Labor
Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being
The purpose of this study is to determine whether fluoride supplementation during pregnancy is effective in extending the length of gestation and improving overall perinatal well-being.
- Conditions
- Preterm Birth, Preterm Labor, Bacteremia, Preterm Premature Rupture of Fetal Membranes
- Trial name
- NCT02536352
- Testing
- Prenatal vitamin-mineral containing 3 mg fluoride, Prenatal vitamin-mineral containing 0 mg fluoride
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Premature Rupture of Membrane, Induction of Labor Affected Fetus / Newborn
PROMMO Trial: Oral Misoprostol vs IV Oxytocin
This is a prospective, randomized trial looking at the ideal method of labor induction for women with prelabor rupture of membranes and an unfavorable cervical Bishop score.
- Trial name
- PROMMO (NCT04478942)
- Testing
- Misoprostol Oral Product, Intravenous Oxytocin
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Labor Complication
Intrapartum Ultrasound in Labor: Sonography Only, Few Internal Examinations
This is a prospective, randomized trial to determine whether the use of sonographic parameters during labor results in less intrapartum infection compared to traditional invasive examination.
- Trial name
- SOFIE (NCT06261710)
- Testing
- Sonography in labour
- Where
- Germany
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Larry Hinkson
Threatened Premature Birth, Premature Membrane Rupture
Intervention for Fear of Childbirth in High-Risk Pregnant Women
The aim of the study is to examine the effects of mandala activity applied to pregnant women hospitalized due to high-risk pregnancies on pregnancy stress and fear of childbirth. The study was designed as an experimental study.
- Conditions
- Threatened Premature Birth, Premature Membrane Rupture, Gestational Hypertension, Intrauterine Growth Retardation (IUGR)
- Trial name
- NCT06716710
- Testing
- Art therapy group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
PROM, Satisfaction, Patient
Assessment of the Humanisation of Care in Hospitals in Andalusia-Spain
Observational assessment through patient interviews of relational, structural and organisational aspects related to the humanisation of health care.
- Conditions
- PROM, Satisfaction, Patient, Satisfaction, Personal, Stress
- Trial name
- HUMANCUIDA (NCT06174844)
- Testing
- No intervention applied
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Seville
Fetal Membranes, Premature Rupture
Myometrial Thickness as a Predictor for the Latency Interval in PPROM
100 women divided into 3 groups: Group I: included 50 women with preterm premature rupture of membranes (PPROM, n=50) with gestational age from 24 to 34 weeks.
- Trial name
- NCT02380560
- Testing
- Ultrasonographic examination
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Labor, Induction
Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin
Prelabor rupture of membranes (PROM) is most commonly defined as rupture of membranes before the onset of labor and occurs in 8% of term pregnancies.
- Conditions
- Labor, Induction, PROM (Pregnancy)
- Trial name
- NCT01099280
- Testing
- SYNPITAN FORT 5 IU, Propess,SYNPITAN FORT
- Where
- Turkey (Türkiye)
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Preterm Premature Rupture of Membrane
Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes
Randomized controlled trial studying the use of vaginal cleansing with chlorhexidine gluconate for pregnant women with PPROM (preterm pre labor rupture of membranes). The primary outcome will be pregnancy latency.
- Trial name
- NCT04516226
- Testing
- Vaginal cleansing with chlorhexidine gluconate solution
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
PPROM
Digital vs. Speculum Exams for PPROM
After preterm prelabor rupture of membranes (PPROM)[breaking of the amniotic sac prior to 37 weeks gestation in pregnancy], patients are recommended for inpatient admission and close monitoring for complications including preterm…
- Trial name
- MOCA (NCT05773014)
- Testing
- Speculum Exams, Digital Exams
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine