Clinical trials: PTSD - Post Traumatic Stress Disorder
Posttraumatic Stress Disorder
Improving Psychosocial Functioning in Older Veterans With PTSD
The purpose of this project is to develop an intervention to improve psychosocial functioning and quality of life for older Veterans with partial or full PTSD.
- Trial name
- NCT02803125
- Testing
- Psychosocial intervention, Support group control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, TBI (Traumatic Brain Injury)
Top-Down Executive Control in Traumatic Brain Injury (TBI), PTSD and Combined
This research investigates processes involved with one being able to focus on relevant information and ignore non-relevant information in veterans with PTSD and those with a history of traumatic brain injury.
- Trial name
- NCT01072006
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body.
- Trial name
- NCT01466127
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Smoking Cessation
Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD)
The investigators propose to evaluate the relationship between PTSD, mood, craving and withdrawal symptoms and factors associated with relapse in the context of a randomized clinical smoking cessation trial.
- Trial name
- NCT01055886
- Testing
- nicotine patch
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Duke University
Posttraumatic Stress Disorder
MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder
The goal of this clinical trial is to compare MDMA-assisted therapy to placebo with therapy in people with chronic, treatment-resistant posttraumatic stress disorder (PTSD).
- Trial name
- NCT00090064
- Testing
- Midomafetamine HCl, Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Resilient Pharmaceuticals
Post-Traumatic Stress Disorder, Substance Use Disorders
Effectiveness of Peer-Delivered Trauma-Specific Treatment
Patient-Centered Trauma Treatment, i.e., treatment delivered by peers with lived-experience, has the potential to increase access to trauma treatment in underserved communities.
- Trial name
- NCT02081417
- Testing
- Seeking Safety
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of New Mexico
Combat Disorders, Posttraumatic Stress Disorder
Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms
The goals of the proposed research are to produce preliminary evidence of PE with OEF/OIF veterans with PTSD and to examine cognitive, psychophysiological, and neuroendocrine mechanisms of change in PTSD treatment.
- Trial name
- NCT00475241
- Testing
- Prolonged Exposure therapy for PTSD, Present centered therapy for PTSD
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
PTSD
Prolonged Exposure and Oxytocin
Posttraumatic stress disorder (PTSD) is a chronic, debilitating anxiety disorder that may develop after direct or indirect exposure to traumatic events.
- Trial name
- NCT03238924
- Testing
- Oxytocin
- Volunteers
- 17 people
- Sponsor
- Medical University of South Carolina
PTSD
Clinician-Supported PTSD Coach vs. Self-Managed PTSD Coach
PTSD Coach is a mobile application (app) that aims to teach individuals self-management strategies for symptoms of Post-traumatic Stress Disorder (PTSD).
- Trial name
- NCT02400710
- Testing
- Clinician-Supported PTSD Coach, Self-Managed PTSD Coach
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Syracuse VA Medical Center
Posttraumatic Stress Disorder
An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder
This is an open-label pilot study of adjunctive asenapine for the treatment of Posttraumatic Stress Disorder (PTSD) in veterans who have not fully remitted to an adequate trial of standard antidepressant treatment.
- Trial name
- NCT01587118
- Testing
- Adjunctive asenapine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Lori Davis, MD
Post Traumatic Stress Disorders, Burns
Cranial Electrotherapy Stimulation in Burned Patients
To find out if Cranial Electrotherapy Stimulation is a useful treatment for people who have been burned and have Post Traumatic Stress Disorder. CES may be helpful in giving relief to some or all of those symptoms.
- Trial name
- CES (NCT00723008)
- Testing
- Alpha Stim 100 (Cranial Electrotherapy Stimulation)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Army Institute of Surgical Research
Pain, Posttraumatic Stress Disorder
Integrated Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)
The purpose of this study is to examine the efficacy of an integrated treatment for Veterans with comorbid chronic pain and posttraumatic stress disorder (PTSD).
- Trial name
- NCT00127413
- Testing
- Cognitive Behavioral Therapy - Pain, Cognitive Behavioral Therapy-Integrated, Cognitive Processing Therapy - PTSD
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- US Department of Veterans Affairs
Posttraumatic Stress Disorder
Narrative Exposure Therapy (NET)
The purpose of this study is to learn more about Narrative Exposure Therapy for Justice Involved Veterans. This pilot study will examine the feasibility of this intervention in a justice-involved veteran population, and will see…
- Trial name
- NET (NCT03777553)
- Testing
- Narrative Exposure Therapy for Justice-Involved Veterans
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Post-Traumatic Headache
Prazosin for Post-Concussive Headaches
Mild traumatic brain injury (mTBI) caused by blast effects of explosive devices has been called the "signature injury" of soldiers who served in the Iraq and Afghanistan conflicts.
- Trial name
- NCT02965027
- Testing
- Prazosin
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Post-Traumatic Stress Disorder
Safety and Efficacy of NYX-783 in Subjects With Post-Traumatic Stress Disorder
To evaluate the safety, tolerability, and response profile of NYX-783 in a Post-Traumatic Stress Disorder population.
- Trial name
- NCT04044664
- Testing
- NYX-783
- Where
- 37 sites in United States
- Volunteers
- 160 people
- Sponsor
- Aptinyx
Hearing Impairment, Hearing Aid Fitting
Blast Exposed Veterans With Auditory Complaints
The purpose of this study is to study blast-exposed Veterans who report hearing handicap but show normal or near normal results on standard audiometric testing.
- Trial name
- NCT02122458
- Testing
- mild-gain hearing aids with high-frequency emphasis over 6-months
- Where
- 3 sites in United States
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD
Morning Light Treatment at Home to Reduce PTSD Symptoms
There is evidence that some of the circadian photoreceptors, the intrinsically photosensitive retinal ganglion cells (ipRGCs), project directly to the amygdala, an area of the brain implicated in PTSD.
- Trial name
- NCT03513848
- Testing
- Retimer
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rush University Medical Center
PTSD
A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD
Evaluate the long-term safety of TNX-102 SL 5.6 mg taken daily at bedtime over an additional 40 weeks in patients with PTSD who have participated in a double-blind lead-in study and completed an initial 12-week open-label…
- Trial name
- P306 (NCT03508700)
- Testing
- TNX-102 SL 5.6 mg
- Where
- 16 sites in United States
- Volunteers
- 93 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
PTSD, Substance Use Disorders
Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
With this research, the investigators hope to learn if cognitive behavioral therapy (CBT) for posttraumatic stress disorder (PTSD) works in people who have both PTSD and problems with drugs or alcohol.
- Trial name
- CBT (NCT01357577)
- Testing
- Cognitive behavioral therapy for PTSD
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Telemedicine and Anger Management Groups With PTSD Veterans in the Hawaiian Islands
Telemedicine has the potential to profoundly influence the delivery of specialized care to the remote veteran population suffering with PTSD.
- Trial name
- NCT00122109
- Testing
- 12 sessions Anger Management Therapy.
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- US Department of Veterans Affairs