Clinical trials: PVI
Chronic Atrial Fibrillation
CFAE/Spatiotemporal Dispersion Guided Ablation Versus PVI Guided Ablation in Persistent AF
Objective: The purpose of this study is to compare the efficacy and safety of ablation of Atrial Fibrillation (AF) drivers marked by spatiotemporal dispersions and Complex Fractionated Atrial Electrocardiograms (CFAEs) to…
- Trial name
- CIPA (NCT02696265)
- Testing
- CFAE guided ablation, PVI guided ablation
- Where
- 4 sites in France, Japan and 1 more
- Volunteers
- 180 people
- Sponsor
- Diagram B.V.
Persistent Atrial Fibrillation
PVI Alone vs PVI and Linear Ablation for Persistent Atrial Fibrillation (PROMPT AF II)
This study is a prospective, multicenter, open-label, randomized controlled trial to investigate whether a linear ablation in addition to pulmonary vein isolation (PVI) outperforms PVI alone using pulsed field ablation (PFA) in…
- Trial name
- NCT07106970
- Testing
- Linear ablation, PVI alone
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation (AF), Catheter Ablation
PulseSelect Based Pulmonary Vein Isolation and Ablation in Patients With Atrial Fibrillation
Electroanatomical mapping (EAM) based pulmonary vein isolation (PVI) by means of PulseSelect catheter and deep sedation will be compared to fluoroscopy based pulmonary vein isolation in patients with atrial fibrillation in the…
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Pulmonary Vein Isolation
- Trial name
- PVI-PVA (NCT07035288)
- Testing
- EAM based Pulmonary Vein Isolation, Fluoro based pulmonary vein ablation
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Tsiachris Dimitrios
Abdominal Cancer
Tidal Volume Challenge and Reliability of Plethysmography Variability Index
The aim of this study is to investigate whether a temporary increase in tidal volume can predict fluid responsiveness in patients receiving a low tidal volume ventilation in hepatobiliary and pancreatic surgeries.
- Trial name
- NCT03546179
- Testing
- tidal volume challenge test, Volume loading
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Fayoum University Hospital
Spinal Induced Hypotension
PVI for Prediction of Spinal Induced Hypotension
The hypothesis is that plethysmography variability index can predict the occurrence of hypotension after spinal anesthesia for cesarean delivery
- Trial name
- NCT01967914
- Testing
- PVI
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Atrial Fibrillation (AF)
COCONUT Study Concomitant PVI and LAAC
In patients with non-valvular AF, at high stroke risk, and who are ineligible for long-term oral anticoagulation LAAC could be an alternative to anticoagulation and safety and efficacy has been shown in several studies and…
- Trial name
- COCONUT (NCT06861673)
- Testing
- Pulmonary vein isolation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Asklepios proresearch
Ventricular Dysfunction
Hemodynamic Indices Predictive of a Beneficial Response to Fluid Expansion in Case of Hemodynamic Failure After Cardiac Surgery With Altered Preoperative Ejection Fraction (LVEF≤45%)
Low Cardiac Output Syndrome occurs frequently after cardiac surgery, especially when pre-operative LVEF is altered (LVEF≤45%). The correction of hemodynamic failure requires adapted treatments: fluid expansion and/or inotropic or…
- Trial name
- ALTERVOL (NCT01673230)
- Testing
- cardiac surgery for ventricular dysfunction
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Atrial Fibrillation
Conventional Versus RF Needle Transseptal Puncture for Cryoballoon Ablation
This will be a prospective single-blinded, randomized, controlled trial comparing the effectiveness and safety of transseptal puncture using the Baylis transseptal system to transseptal left atrial access with standard…
- Trial name
- CRYO-LATS (NCT03199703)
- Testing
- Baylis transseptal system group, Standard conventional transseptal group
- Where
- 6 sites in Canada
- Volunteers
- 135 people
- Sponsor
- Jason Andrade
Scoliosis
Accuracy of Pleth Variability Index (PVI) in Children
Plethysmographic Variability index is a simple index accurate in predicting fluid responsiveness. The aim of this study was to investigate its accuracy in predicting fluid response to intravenous fluid challenge during scoliosis…
- Trial name
- PVI (NCT01820845)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pleth Variability Index, Lung Recruitment Maneuver
Evaluation of Fluid Responsiveness With Pulse Variation Index and Systolic Blood Pressure Changes After Lung Recruitment Maneuver
Evaluation of Fluid Responsiveness With Pulse Variation Index and Systolic Blood Pressure Changes After Lung Recruitment Maneuver
- Conditions
- Pleth Variability Index, Lung Recruitment Maneuver, Fluid Responsiveness
- Trial name
- NCT04939129
- Testing
- The research is terminated by calculating the percentage of PVI changes with SAB formed by LRM after fluid challenge.
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara City Hospital Bilkent
Atrial Fibrillation
Timing of Direct Current Cardioversion (DCC) in Patients Undergoing Ablation of Persistent/Permanent Atrial Fibrillation
The purpose of this study is to compare which strategy is superior in patients with persistent/permanent atrial fibrillation (AF) undergoing ablation, direct current cardioversion (DCC) prior to empirical pulmonary vein isolation…
- Trial name
- NCT02429648
- Testing
- DCC first then PVI, PVI then DCC after
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation
Pulmonary Vein Ablation Versus Amiodarone in the Elderly
The purpose of the study is to demonstrate that in patients of 70 years or older with symptomatic paroxysmal atrial fibrillation (AF) pulmonary vein isolation (PVI) using RF ablation therapy is superior to medical treatment with…
- Trial name
- PAVANE (NCT01276093)
- Testing
- PVI ablation, Amiodarone
- Where
- 6 sites in Netherlands
- Volunteers
- 59 people
- Sponsor
- Abbott Medical Devices
Fluid Overload
Goal Directed Fluid Management , Pvi
The first objective of this study is to compare the liberal fluid management (LFM) with PVI guided goal-directed fluid management (GDFM) in gynecologic oncologic cases in terms of controlled intraoperative fluid balance, blood…
- Trial name
- NCT03956901
- Testing
- pvi guided fluid management
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Surgery
Effect of the Pneumoperitoneum on Dynamic Variables Delta PP and PVI During Trendelenburg Position.
Arterial pulse pressure variation induced by mechanical ventilation (ΔPP) is considered one of the best parameter to predict fluid responsiveness in patients under general anaesthesia.
- Trial name
- NCT02709252
- Testing
- PVI and deltaPP after trendelenburg position change
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Brugmann University Hospital
Peripheral Vascular Interventions
Assessment of Clin. Capabilities of LIBERTY® Endovascular Robotic System's Performance & Safety in Periph. Vasc. Interv.
A prospective, multi-center, single-arm, study to evaluate the performance and safety of the LIBERTY® Robotic System in human subjects undergoing Peripheral Vascular Interventions.
- Trial name
- ACCESS-PVI (NCT06141694)
- Testing
- The LIBERTY® Robotic System
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Microbot Medical, INC
Atrial Fibrillation
Use of Volta Medical AI-software During Atrial Fibrillation Ablation to Identify Patients Who May Need More Than Pulmonary Vein Isolation.
DISPLAY-AF is a prospective, multicenter, single-arm post-market clinical follow-up investigation designed to evaluate whether spatiotemporal dispersion areas identified by the Volta AF-Xplorer II artificial intelligence (AI)…
- Trial name
- DISPLAY-AF (NCT07807423)
- Testing
- Complete biatrial mapping
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Volta Medical
Peripheral Artery Disease
Radial accEss for nAvigation to Your CHosen Lesion for Peripheral Vascular Intervention: REACH PVI
The objective of this study is to evaluate acute clinical results of orbital atherectomy (OA) via radial artery access, including complication rates and cost effectiveness.
- Trial name
- REACH PVI (NCT03943160)
- Testing
- Diamondback 360 Extended Length Orbital Atherectomy System
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Abbott Medical Devices
Surgical Site Infection
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF)…
- Trial name
- POTENT (NCT05763602)
- Testing
- povidone-iodine topical ointment
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Loreen Herwaldt
Atrial Fibrillation (AF)
Feasibility, Safety, Cost-effectiveness, and Environmental Impact of Reprocessed Ablation Catheters in PVI
This study evaluates whether re-sterilized (reprocessed) ablation catheters are as effective and safe as new ablation catheters when used for pulmonary vein isolation in patients with atrial fibrillation.
- Trial name
- RE-USE PVI (NCT07389434)
- Testing
- Participants will undergo pulmonary vein isolation using pulsed field ablation (PFA). The intervention consists of the use of either a reprocessed electroporation ablation catheter or a new electropor
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University Hospital Dubrava
Atrial Fibrillation
Evaluating PVI Using CMR
Using state of the art cardiac magnetic resonance imaging techniques, characterization of ablation lesions in the early phase after pulmonary vein isolation ablation in atrial fibrillation patients, and relate findings to the…
- Trial name
- NCT05437549
- Testing
- MRI
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc