Clinical trials: Pacing Therapy
Atrioventricular Block, Heart Diseases
Biventricular Versus Right Ventricular Pacing in Heart Failure Patients With Atrioventricular Block (BLOCK HF)
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Trial name
- BLOCK HF (NCT00267098)
- Testing
- Cardiac Resynchronization Therapy (CRT)
- Where
- 54 sites in United States, Canada
- Volunteers
- 918 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, Ventricular Arrhythmias and Cardiac Arrest
Effects of Upgrading From Right Ventricular Pacing to Cardiac Resynchronization Therapy and Comparison With Dual-Chamber Defibrillator
Patients who consecutively underwent de novo CRT implantation, CRT upgrade, and DDDR ICD implantation at the Cardiology Clinic of Bursa Postgraduate Hospital between January 2019 and December 2023 according to the European…
- Trial name
- NCT07077928
- Testing
- Pacemaker upgrade
- Where
- Turkey (Türkiye)
- Volunteers
- 307 people
- Sponsor
- Bursa Postgraduate Hospital
Permanent Atrial Fibrillation
Atrioventricular Junction Ablation and Biventricular Pacing for Atrial Fibrillation and Heart Failure
There is evidence of superiority of AV junction ablation strategy over pharmacological therapy only for symptoms of atrial fibrillation, but not for heart failure, hospitalization, morbidity and mortality.
- Trial name
- APAF-CRT (NCT02137187)
- Testing
- AV junction ablation, CRT, Optimized drug therapy
- Where
- Italy
- Volunteers
- 1,830 people
- Sponsor
- Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella
Ventilator Induced Diaphragm Dysfunction
A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation
This clinical investigation is an open-label, multi-center RCT to demonstrate the safety and effective performance of the Lungpacer DPTS (plus standard of care) as compared to Control (standard of care only) in patients aged 18…
- Trial name
- RESCUE 3 (NCT03783884)
- Testing
- Lungpacer Diaphragm Pacing Therapy
- Where
- 33 sites in United States, France and 1 more
- Volunteers
- 223 people
- Sponsor
- Lungpacer Medical Inc.
Cardiomyopathy, Hypertrophic
Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy
The main aim of this study is to assess the acute effects of a pacemaker on reducing abnormally high intracavity pressures in the hearts of patients with mid-cavity obstructive hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT03450252
- Testing
- Active pacing, Back-up pacing
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Barts & The London NHS Trust
Congestive Heart Failure
Electrophysiological Optimization of Left Ventricular Lead Placement in CRT
The purpose of this study is to investigate if "optimal electrical resynchronization" achieved by targeting left ventricular lead placement to the myocardial region with the latest electrical activation combined with post-implant…
- Trial name
- ElectroCRT (NCT02346097)
- Testing
- Cardiac Resynchronization Therapy (St. Jude Qaudripolar LV lead)
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- University of Aarhus
Conduction System Pacing, Pacing Therapy
Solutions to the Challenges of Conduction System Pacing
Conduction system pacing is a new way of stimulating the heart using pacemaker wires. Traditional pacemakers stimulate the heart muscle which causes disordered heart beats: the walls of the heart move at different times.
- Trial name
- CSA (NCT07009834)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Imperial College London
Heart Failure, Left Ventricular Dysfunction
Use of 3-D Blood Pool Scintigraphy to Guide Left Ventricular Pacing Lead Placement in Patients Requiring Cardiac Resynchronization Therapy
The purpose of this study is to determine whether multiple gated acquisition (MUGA) guided lead placement improves clinical outcomes for patients needing cardiac resynchronization therapy (CRT) compared to traditional…
- Conditions
- Heart Failure, Left Ventricular Dysfunction, Cardiac Resynchronization Therapy
- Trial name
- MUGA CRT (NCT02669290)
- Testing
- Guided, Non-guided
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Atrioventricular Block
Ventricular Pacing Site Selection (V-PASS)
The purpose of this study is to determine whether there is a relationship between ventricular lead position and the incidence of heart failure and atrial fibrillation in patients with indication for permanent pacemaker…
- Trial name
- NCT00292383
- Testing
- Leads to be implanted according randomization on specified sites. Vitatron pacemakers to be implanted: T60 DR, T70 DR, T20 SR, C60 DR
- Where
- 3 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Medtronic BRC
Heart Failure With Preserved Ejection Fraction (HFpEF), Hypertension
Study for the Treatment of Heart Failure With Preserved Ejection Fraction Associated With High Blood Pressure Using Right Atrial Pacing Controlled by the PressurePaceTM System
This study is a prospective, double blind, self-controlled, randomized, cross-over study to evaluate the feasibility, efficacy, and safety of treating patients with Heart Failure with preserved Ejection Fraction (HFpEF)…
- Trial name
- RelieveHFpEFII (NCT06036186)
- Testing
- BaroPacing treatment, Standard treatment
- Where
- 3 sites in India
- Volunteers
- 16 people
- Sponsor
- BaroPace Inc.
Heart Failure
CT Guided WiSE-CRT
This feasibility study will use CT scanning to identify the optimal location for placement of the WiSE-CRT system.
- Trial name
- NCT03495505
- Testing
- WiSE-CRT
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diabetes, Heart Failure
Multipolar CRT-d and Diabetes
Background: Type 2 Diabetes Mellitus (T2DM) is a multi factorial disease, affecting clinical outcomes in failing heart (HF) patients treated by Cardiac Resynchronization Therapy with a defibrillator (CRT-d).
- Conditions
- Diabetes, Heart Failure, Heart Failure NYHA Class II, Heart Failure NYHA Class III
- Trial name
- NCT03095196
- Testing
- Multipolar CRT-d, plus conventional drug therapy for HF., Bipolar CRT-d, plus conventional drug therapy for HF., HF drugs
- Volunteers
- 190 people
- Sponsor
- Celestino Sardu