Clinical trials: Packed Red Blood Cells
Thalassemia Major
Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients
This study compares the effects of Packed Red Blood Cells (PRBCs) prepared in two different ways on the transfusion indices in beta(ß)-Thalassemia transfusion-dependent patients.
- Trial name
- NCT03992001
- Testing
- Blood component A, Blood component B
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Università degli Studi di Ferrara
Blood Donors
Evaluation of Whole Blood With CPD Anticoagulant and AS-7/SOLX Additive Solution
This study will evaluate a new blood collection and filtration system that is intended to be used to collect, filter, separate and store red blood cells and, separately, plasma.
- Trial name
- NCT02145507
- Testing
- SOLX (Investigational), AS-3 (Control)
- Where
- 2 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Haemonetics Corporation
Bleeding as Surgical Complication (Treatment)
HemOx Transfusion Trial
The proposed project, entitled "HemOx Transfusion Study", investigates the functionality of red blood cells (erythrocytes) in the context of oxygen transport in the blood.
- Trial name
- NCT07677150
- Testing
- autologous maschine transfusion - intraoperative cell salvage, packed red blood cells
- Where
- Austria
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Disorder Related to Renal Transplantation, Transfusion Reaction
Old Red Blood Cell In Renal Transplantation
Kidney transplantation is the treatment of choice for ESRD. However, the life expectancy of kidney transplant patients is lower than that of the general population.
- Trial name
- ORBIT (NCT02841111)
- Volunteers
- 12,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Transfusion Related Complication
Effects of Packed Red Blood Cell Storage Duration on Pediatric Living Donor Liver Transplantation
The patients assigned to either short-storage leukoreduced RBCs group (stored for ≤ 14 days) or longer-term storage leukoreduced RBCs group(stored for ≥21 days).When the hemoglobin concentration fell below 7.0 g per deciliter…
- Trial name
- NCT04413721
- Testing
- RBC transfustion
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Renal Failure
Impact of the Composition of Packed Red Blood Cell Supernatant on Renal Dysfunction and Posttransfusion Immunomodulation
Safety during transfusions is a major issue in medical economics. Despite drastic quality control measures, transfusion is still a source of short, mid and long-term morbi-mortality.
- Trial name
- TRANSNEPHRON (NCT02763410)
- Testing
- PRBC transfusion
- Where
- France
- Volunteers
- 199 people
- Sponsor
- Nantes University Hospital
Packed Red Blood Cells
Interleukin-8 Level in Packed Red Blood Cells
1. To compare level of interleukin-8 between leukodepleted and non-leukodepleted packed red blood cells. 2. To show the effect of filtration of packed red blood cells on the level of inflammatory interleukin-8.
- Trial name
- NCT06530160
- Testing
- ELISA
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Assiut University
Surgery, Erythrocyte Transfusion
European Transfusion Practice and Outcome Study
The aim of the ETPOS study is to describe differences in transfusion habits throughout Europe and to correlate these habits to perioperative outcome parameters.
- Conditions
- Surgery, Erythrocyte Transfusion, Habits, Anemia
- Trial name
- ETPOS (NCT01604083)
- Where
- 9 sites in Croatia, Czechia and 6 more
- Volunteers
- 6,066 people
- Sponsor
- European Society of Anaesthesiology
Heart Defects, Congenital
Rejuvenated, Washed Packed Red Blood Cells in Pediatric Cardiac Surgery
Blood transfusion is nearly always needed during open heart surgery in children less than 15 kg (35 pounds). The purpose of the red blood cells in the blood is to deliver oxygen to the organs and tissues of the body.
- Trial name
- NCT02485366
- Testing
- Rejuvesol, Cardiac surgery
- Where
- United States
- Sponsor
- Duke University
Preterm Birth, Blood Transfusion Complication
Blood Warming in Preterm Infants to Decrease Hypothermia
Background/significance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia.
- Conditions
- Preterm Birth, Blood Transfusion Complication, Hypothermia
- Trial name
- NCT05170633
- Testing
- Ranger blood warmer (3M Healthcare, Oakdale, Minnesota)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Burn Injury
Transfusion Ratio of Fresh Frozen Plasma (FFP) to Packed Red Blood Cell (PRBC) During Burn Excision and Grafting
The purpose of this study is to determine if burn injured patients who receive blood transfusions in the operating room have better outcomes when given transfusions at a set ratio (1:1)of PRBC to FFP.
- Trial name
- FFP (NCT05063409)
- Testing
- Treatment
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Shriners Hospitals for Children
Postpartum Anemia Nos
SMaRT Blood: Single-unit Versus Multiple-unit Packed Red Blood Cell Transfusion in Non-acute Postpartum Anemia
There is a paucity of data on management of non-acute postpartum anemia. Although blood transfusions were historically initiated with 2 units, the most recent recommendation from the American Association of Blood Banks is to…
- Trial name
- SMaRTBlood (NCT03419780)
- Testing
- Blood Transfusion
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Pennsylvania
Fibrin Blood Clot
Impact of Two Guided Transfusion Strategies on Blood Product Requirements in Liver Transplantation.
It is a national multicentre clinical study, where 3 hospitals are involved: Bellvitge University Hospital, Clinic Hospital of Barcelona and Cruces Hospital of Bilbao).
- Trial name
- NCT04405518
- Testing
- Fibrinogen Concentrate (Human) 1 MG [RiaSTAP]
- Where
- 3 sites in Spain
- Volunteers
- 188 people
- Sponsor
- Antoni Sabaté Pes
Hip Fractures
Efficacy of Ferric Carboxymaltose With or Without EPO Reducing Red-cell Transfusion Packs in Hip Fracture Perioperative Period
In order to evaluate the efficacy of ferric carboxymaltose + erythropoietin versus ferric carboxymaltose versus placebo in reducing the percentage of patients who receive red-cell transfusion in the perioperative period of hip…
- Trial name
- PAHFRAC (NCT01154491)
- Testing
- Ferric carboxymaltose, Erythropoietin
- Where
- 14 sites in Spain
- Volunteers
- 303 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia
Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia
This clinical trial evaluates the effects of hemoglobin threshold-specific packed red blood cell (PRBC) transfusions on quality of life and functional outcomes in patients who have undergone chemotherapy or an allogeneic…
- Conditions
- Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Myeloid Neoplasm
- Trial name
- NCT06710418
- Testing
- Activity Tracking, Biospecimen Collection, Cognitive Assessment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington
Cardiac Arrest
Packed Red Blood Cell Transfusion During Cardiac Arrest
The purpose of this pilot interventional study is to collect preliminary data on administering packed red blood cell (PRBC) during cardiac arrest (CA).
- Trial name
- NCT06462027
- Testing
- Packed Red Blood Cells (1 unit), Packed Red Blood Cells (2 units), Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Iron Overload
MRI T2* Mapping of Myocardium, Liver, Pancreas and Pituitary Gland
All patients were investigated using a 3T MRI and 1,5 T MRI scanners. For myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for T2*-mapping.
- Trial name
- NCT04835285
- Testing
- Npf.
- Where
- Russia
- Volunteers
- 152 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD)
The Correlation Between Red Cell Transfusion and Complications of Prematurity
The aim of this clinical trial is to learn if there is a correlation between the erythrocyte transfusion in the early neonatal period in premature infants and early and late complications of prematurity.
- Conditions
- Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD), Enterocolitis, Necrotizing, Intraventricular Hemorrhage Neonatal
- Trial name
- NCT07123948
- Testing
- Wechsler Intelligence Test, performed by educated psychologists
- Where
- Croatia
- Volunteers
- 128 people
- Sponsor
- Clinical Hospital Center Rijeka
Intestinal Blood Flow
Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates
The purpose of the study is to determine whether packed red blood cell (PRBC) transfusion affects intestinal blood flow of premature infants during feedings and if so, whether return of normal intestinal blood flow pattern occurs…
- Trial name
- NCT01628133
- Testing
- ultrasound
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- St. Louis University
Leucodepletion of Packed RBC
Impact of Lecuofiltration of Packed Red Blood Cells on Different Hematological Parameters Measured by Advia 2120
Parameters of lecuofiltration of packed Red blood cells.
- Trial name
- NCT06151977
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assiut University