Clinical trials: Pain, Acute
Total Knee Arthroplasty
Acute Effects of Strengthening Lower Limbs Operated by Total Knee Arthroplasty
Knee osteoarthritis is a chronic joint disease and one of the leading causes of disability among adults, resulting in irreversible damage to articular cartilage and subchondral bone, osteophyte formation, joint pain and…
- Trial name
- AESLLKNEE (NCT05444400)
- Testing
- Strengthening, Conventional protocol
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Valencia
Acute Pain
Ketamine for Pain in the Emergency Department
This study will prospectively compare the mean Numerical Rating Scale (NRS) pain score reduction amongst three recommended dosing strategies of intravenous ketamine (0.1 mg/kg, 0.2 mg/kg, and 0.3mg/kg) for acute pain in the…
- Trial name
- NCT03896230
- Testing
- Ketamine Injectable Product
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Hackensack Meridian Health
Pain, Acute, Rib Fractures
Mid-point to Pleura Transverse Process Block Versus Thoracic Intervertebral Foramen Block
The analgesic effect of continuous mid-point to pleura transverse process block compared to the analgesic effect of continuous thoracic intervertebral foramen block, in patients with multiple rib fractures.
- Conditions
- Pain, Acute, Rib Fractures, Polytrauma
- Trial name
- NCT05348330
- Testing
- Thoracic intervertebral foramen block, Mid-point to pleura transverse process block
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Calibration Study PREDICT - Prehospital Triage for Suspected Acute Coronary Syndrome Without ST-segment Elevation
The PREDICT calibration study is a prospective, non-interventional trial aiming to adapt and calibrate the ACS-Pathfinder algorithm for prehospital triage of patients with suspected non-ST-elevation acute coronary syndrome…
- Trial name
- PREDICT (NCT07419139)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Leipzig Heart Science gGmbH
Whiplash Injuries
Manual Therapy Dosage Factorial Study
This study will determine biological responses to different dosages of neck mobilization intervention in patients, providing opportunities to identify the optimal dosage, predictors of response, outcome measures as well as the…
- Trial name
- NCT00560807
- Testing
- Mobilization
- Where
- Canada
- Sponsor
- McMaster University
Coxarthrosis, Pain, Postoperative
Lumbar ESPB in Hip Replacement Surgery
In this study, continuous erector spinae plane block (ESPB) will be compared to continuous epidural analgesia in patients undergoing elective hip replacement surgery.
- Conditions
- Coxarthrosis, Pain, Postoperative, Pain, Acute, Pain, Chronic
- Trial name
- ESPB_HIP (NCT06282666)
- Testing
- Spinal anesthesia, lumbar erector spinae plane block, Epidural analgesia
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Dental Pain
Maxigesic 325 Acute Dental Pain Study
The purpose of this study is to determine whether the analgesic effects of Maxigesic USA are greater than acetaminophen, ibuprofen or placebo.
- Trial name
- NCT01420653
- Testing
- Maxigesic 325, Acetaminophen, Ibuprofen
- Where
- 4 sites in United States, New Zealand
- Volunteers
- 408 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Hemorrhoidectomy, Hemorrhoid Pain
Acupuncture for Post-hemorrhoidectomy Pain Control
The goal of this clinical trial is to learn if acupuncture improves pain control after hemorrhoidectomy in patients with symptomatic hemorrhoids. It will also learn about the safety of using acupuncture in surgical patients.
- Conditions
- Hemorrhoidectomy, Hemorrhoid Pain, Acupuncture
- Trial name
- NCT07238504
- Testing
- Acupuncture
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Acute Pain
Effect of Early Pain Management at Triage on Opioid Consumption
introduction: Pain remains one of the most common reasons of emergency department admission. Opioids are overprescribed in emergency departments to treat severe pain.
- Trial name
- NCT03243006
- Testing
- Paracetamol, Tramadol/Paracetamol combination
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Coronary Angiography, Chest Pain
Coronary Computed Tomography for Systematic Triage of Acute Chest Pain Patients to Treatment (CT-STAT)
This is a prospective, randomized multicenter trial comparing MSCT to standard of care (SOC) diagnostic treatment in the triage of Emergency Department (ED) low to intermediate risk chest pain patients.
- Trial name
- CTSTAT (NCT00468325)
- Testing
- Multi-slice computed tomography, Rest-stress Nuclear Myocardial Perfusion Imaging
- Where
- 16 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Nausea, Abdominal Pain
Ondansetron Versus Dexamethasone/Ondansetron to Treat Acute Nausea in the Emergency Department
Nausea is a common complaint in patients who present to the emergency department (ED). Although the number of conditions that can present with nausea are numerous, the mainstay of treatment has become intravenous ondansetron…
- Trial name
- NCT02985840
- Testing
- Ondansetron, Dexamethasone
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- OhioHealth
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Pain, Acute, Anxiety Acute
The Effect of Music Played and Acupressure Application on Pain and Anxiety in Women Undergoing Gynecological Examination
This study was carried out to determine the effect of listening to music and acupressure application in reducing pain and anxiety during gynecological examination.
- Trial name
- NCT04356820
- Testing
- acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Adiyaman University Research Hospital
Sub-acute Non-specific Low Back Pain
Low Load Blood Flow Restriction Training Versus Traditional Heavy Load Resistance Training in Male Athletes With Sub-acute Non-specific Low Back Pain
his randomized clinical trial aims to compare the effects of low-load blood flow restriction (LL-BFR) training and traditional heavy-load resistance training (HL-RT) on male athletes with sub-acute non-specific low back pain.
- Trial name
- NCT07480759
- Testing
- Low Load Blood Flow Restriction Training (LL-BFR), Traditional Heavy Load Resistance Training (HL-RT)
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- University of Lahore
Post Operative Pain, Acute
A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia
- Trial name
- NCT05971368
- Testing
- thoracic paravertebal block, serratus anterior muscle block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Acute, Analgesia
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
Using a retrospective review of records, we will conduct a multivariate analysis to examine the relationship between exposure to ketamine, as an analgesic agent in combat related trauma care, the use of additional opioid pain…
- Conditions
- Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder
- Trial name
- NCT04057989
- Testing
- ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Chest Pain, Coronary Artery Disease
Trial of Cardiac CT in Acute Chest Patients With Intermediate Level Initial High-sensitivity Cardiac Troponin
Patients who present to the emergency department (ED) with acute chest pain (ACP) possibly due to Coronary artery disease (CAD), with a normal heart tracing (ECG), need to have further troponin blood tests to confirm or exclude a…
- Conditions
- Chest Pain, Coronary Artery Disease, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- PROTECCT (NCT03583320)
- Testing
- Cardiac CT angiogram
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Back Pain, Muscle Pain
Transcutaneous Electrical Nerve Stimulation for Back Pain in the Emergency Department (TENS-ED)
The effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) to reduce pain scores for patients with acute back pain in an ambulatory emergency department (ED) population will be examined in this dual-center, cluster…
- Conditions
- Back Pain, Muscle Pain, Acute Pain, Lower Back Pain
- Trial name
- TENS-ED (NCT05601843)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sam Brophy
Head Pain
Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department
Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department
- Trial name
- NCT05325580
- Testing
- Magnesium sulfate
- Where
- Tunisia
- Volunteers
- 424 people
- Sponsor
- University of Monastir
Dementia
Use of MEOPA (Equimolar Mixture of Nitrogen Protoxide and Oxygen) for Elderly With Dementia
Acute pain is frequent in elderly especially in geriatrics acute care units where painful procedures are often occurring. MEOPA represents an alternative to opioïd therapy to prevent procedural pain during the treatment of…
- Trial name
- NCT00822224
- Testing
- MEOPA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice