Clinical trials: Pain, Chronic Disease
Chronic Neck Pain
Kinesiophobia, Pain and Disability in Chronic Neck Pain
This study aims to investigate the mediating role of kinesiophobia in the relationship between pain intensity and disability in individuals with chronic neck pain.
- Trial name
- NCT07525557
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ondokuz Mayıs University
Pain Management, Severe Chronic Pain
Patient Registry of Intrathecal Pain Management in Europe for Prialt (Ziconotide Intrathecal Infusion) and Alternative Drugs for the Management of Severe, Chronic Pain.
This is an open-label, long-term, multi-center multi-national post-marketing observational registry. The objective of this study is to monitor the long-term efficacy, safety, tolerability and quality of life outcomes associated…
- Trial name
- PRIME (NCT02268812)
- Volunteers
- 219 people
- Sponsor
- Eisai Limited
Chronic Low-back Pain, Mastectomy
EMG Biofeedback Treatment for Chronic Low Back Pain, Cancer Pain and Migraines
The purpose of this pilot efficacy study is to examine the effects of EMG-biofeedback (EMG-BF) on pain-related outcomes in Chronic Low Back Pain (CLBP) patients, Recent mastectomy and lumpectomy patients, and patients with…
- Conditions
- Chronic Low-back Pain, Mastectomy, Lumpectomy, Migraine
- Trial name
- BEAT-Pain (NCT04607460)
- Testing
- JOGO Digital Therapeutics EMG Biofeedback for Lower Back Pain, JOGO Digital Therapeutics EMG Biofeedback for Persistent Post Mastectomy Pain, JOGO Digital Therapeutics EMG Biofeedback for Migraine
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Brigham and Women's Hospital
Long COVID, Pain
Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID
The goal of this preliminary study is to test methods and procedures to be used in a fully-powered trial to evaluate acupuncture treatment effectiveness.
- Trial name
- NCT06476496
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Washington
Spinal Cord Stimulation, Deep Brain Stimulation
Implantable Systems Performance Registry
The Implantable Systems Performance Registry (ISPR) was developed to evaluate the long-term reliability and performance of market-released Medtronic Neuromodulation infusion and stimulation products.
- Conditions
- Spinal Cord Stimulation, Deep Brain Stimulation, Drug Infusion (Implantable Pumps), Sacral Neuromodulation
- Trial name
- ISPR (NCT00959296)
- Testing
- Various
- Where
- 50 sites in United States, Austria and 5 more
- Volunteers
- 10,981 people
- Sponsor
- MedtronicNeuro
Chronic Pain
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients
Accuracy of Point of Care (POC) or In-office Urine Drug Testing (Immunoassay) in Chronic Pain Patients: A Prospective Analysis of Immunoassay and Liquid Chromatography Tandem Mass Spectometry (LC/MS/MS)
- Trial name
- NCT01052155
- Testing
- Urine Drug Testing
- Volunteers
- 1,000 people
- Sponsor
- Pain Management Center of Paducah
Repetitive Transcranial Magnetic Stimulation, Chronic Visceral Pain
Lf-rTMS Attenuates Visceral Pain in Irritable Bowel Syndrome With Diarrhea
Objectives: To identify a central hub of visceral pain in IBS-D and elucidate the mechanism by which repetitive transcranial magnetic stimulation (rTMS) confers analgesic effects.
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Chronic Visceral Pain, Functional Magnetic Resonance Imaging, IBS (Irritable Bowel Syndrome)
- Trial name
- NCT06757491
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Coronary Artery Disease, Angina Pectoris
Appropriateness of Angioplasty in Patients With Chronic Coronary Syndromes
Percutaneous coronary intervention (PCI) has dramatically changed the treatment of obstructive coronary artery disease patients.
- Trial name
- RIGHT-PCI (NCT06545448)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- Brazil
- Volunteers
- 1,875 people
- Sponsor
- University of Sao Paulo General Hospital
Opioid Use Disorder, Chronic Pain
Healing Opioid Misuse and Pain Through Engagement (HOPE) Trial
This study is a multisite randomized clinical trial of a treatment designed to reduce pain interference while simultaneously addressing relapse prevention among individuals who have co-occurring chronic pain and Opioid Use…
- Trial name
- HOPE (NCT05571917)
- Testing
- Acceptance and Commitment Therapy + Mindfulness Based Relapse Prevention (ACT + MBRP), Enhance Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- University of New Mexico
Low Back Pain, Recurrent, Degenerative Disc Disease
GDS Muscle and Articulation Chain Treatment for Chronic LBP and Spinal Stenosis
Our purpose is to conduct a pilot study to evaluate GDS muscle and articulation chain treatment for inoperable spine patients with degenerative changes in the lumbar spine, compared to "standard treatment" (any other chosen…
- Trial name
- GDS (NCT04436003)
- Testing
- Muscle and articulation chains GDS method
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hospital of Vestfold
Pain
Evaluation of the Efficacy and Safety of Fentanyl Delivered by Adhesive Skin Patch in Out-Patients With Chronic Cancer Pain
The purpose of this study is to determine the safety and efficacy of pain control by fentanyl, administered via adhesive skin patches, at doses of 25 to 100 micrograms per hour in 80 out-patients with intense chronic cancer pain.
- Trial name
- NCT00236327
- Testing
- fentanyl
- Volunteers
- 34 people
- Sponsor
- Janssen Cilag S.A.S.
Chronic Pain, Sickle Cell Disease
MBI for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease
This study examines the efficacy of a mindfulness-based intervention designed to support pain and sleep management in adolescents and young adults with sickle cell disease.
- Conditions
- Chronic Pain, Sickle Cell Disease, Sleep
- Trial name
- REMedy_RCT (NCT07797582)
- Testing
- Mindfulness-based intervention
- Volunteers
- 48 people
- Sponsor
- University of Illinois Chicago
Opioid Use Disorder (OUD), Chronic Pain
Addiction Treatment in Primary Care Expansion
The Veterans Health Administration (VA) is a national leader in addressing the twin epidemics of chronic pain and opioid use, misuse, and opioid use disorder (OUD); but important challenges remain.
- Trial name
- APEX (NCT03547882)
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Working Memory Deficits, Neuropathic Pain
Working Memory Training for Chronic Neuropathic and Fibromyalgia Pain
The goal of this project is to investigate and improve executive control function in two distinct pain conditions, namely neuropathic pain and fibromyalgia (FM).
- Conditions
- Working Memory Deficits, Neuropathic Pain, Fibromyalgia
- Trial name
- NEPA (NCT02824588)
- Testing
- Working Memory Training, Internet use
- Where
- Norway
- Volunteers
- 82 people
- Sponsor
- Oslo University Hospital
Knee Osteoarthritis, Chronic Knee Pain
Genicular Nerve Radiofrequency Ablation Versus Hyaluronic Acid Injection for Knee Osteoarthritis Pain
The goal of this clinical trial is to learn if thermal radiofrequency ablation of the genicular nerves (the nerves that carry pain signals from the knee) works better than a single injection of hyaluronic acid into the knee to…
- Trial name
- RF-PROSPECTIU (NCT07901374)
- Testing
- Thermal Radiofrequency Ablation of the Genicular Nerves, Intra-articular Hyaluronic Acid
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Persistent Pain, Pain Management
Self-monitoring and Remote Monitoring of Chronic Pain in Primary Care - Using a Digital Tool to Improve Quality of Life
Chronic pain impacts individuals, their families, and society significantly, yet specialist care resources are limited, with most patients managed in primary care.
- Conditions
- Persistent Pain, Pain Management, Remote Monitoring
- Trial name
- NCT07141108
- Testing
- Paindrainer Care system
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University
Coronary Syndrome
WILL lOWer Dose Aspirin be Better With Rivaroxaban in Patients With Chronic Coronary Syndromes?
The trial is a pharmacodynamic study to determine the effect of a novel regimen of aspirin 20 mg BD plus rivaroxaban 2.5 mg BD on haemostasis, fibrin clot dynamics, inflammatory markers, platelet function and arachidonic acid…
- Trial name
- WILLOW CCS (NCT04990791)
- Testing
- Aspirin 75mg, Aspirin 20mg, Rivaroxaban 2.5 mg
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Smoking Cessation
Cognitive Behavioral Smoking Cessation Intervention for Adults With Chronic Pain
Millions of individuals with chronic pain smoke and our preliminary research suggests that currently available strategies to help people quit smoking may not be effective for individuals with chronic pain.
- Trial name
- NCT01091090
- Testing
- Cognitive behavioral, Control
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Mayo Clinic
Hypertension
Postoperative Pain and Angiotensin II Receptor Antagonists
An angiotensin II type 2 receptor (AT2R) antagonist has been assessed for its efficacy in neuropathic pain with promising results.
- Trial name
- PP&ARA (NCT02513979)
- Testing
- Angiotensin type II receptor antagonists
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir