Clinical trials: Pain, Chronic Disease
Chronic Low Back Pain, After Lumbar Spine Surgery
Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery
Chronic low back pain after spinal surgery is a complex and disabling condition influenced by biopsychosocial factors. Cognitive Functional Therapy (CFT) is a promising intervention targeting these multidimensional aspects.
- Conditions
- Chronic Low Back Pain, After Lumbar Spine Surgery, Failed Back Surgery Syndrome (FBSS)
- Trial name
- NCT07576062
- Testing
- CFT
- Volunteers
- 90 people
- Sponsor
- Centro Universitário Augusto Motta
Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive
The Effect of Aromatherapy Massage on Pain, Anxiety and Comfort
Patients in the intensive care unit (ICU) experience physical and psychological discomfort, including pain. Anxiety is a condition frequently encountered in the ICU.
- Conditions
- Respiratory Insufficiency, Pulmonary Disease, Chronic Obstructive, Diabetes Mellitus, Type 2, High Blood Pressure
- Trial name
- NCT06295874
- Testing
- Effect of aromatherapy massage on vital signs, pain, anxiety and comfort level
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nilgün Erdoğan
Pain, Chronic, Posture Disorders in Children
Technology on the Occurrence of Muscoskeletal Disorders in Students
To investgate the long use of electronic devices that forces the person to adopt an uncomfortable posture which leads to the appearance of musculoskeletal disorders such as neck pain, thoracic pain, back pain and tendonitis of…
- Trial name
- NCT05253950
- Testing
- Questionnaire
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Thessaly
Metastatic Breast Cancer, Tumor
Anastrozole Adjuvant Trial - Study of Anastrozole Compared to NOLVADEX (Tamoxifen Citrate) for Adjuvant Treatment of Early Breast Cancer Clinical Studies), Adjunct Cytotoxic Chemotherapy and Malignant Joint Tumor
At a median follow-up of 33 months, the combination of anastrozole and NOLVADEX (tamoxifen citrate) did not demonstrate any efficacy benefit when compared to NOLVADEX (tamoxifen citrate) therapy given alone in all patients as…
- Conditions
- Metastatic Breast Cancer, Tumor, Muscle Neoplasms, Chronic Pain
- Trial name
- NASBP-B-09 (NCT06154590)
- Testing
- Method(s)1 Attribution, Method(s)2 Attribution,
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- DR. DIANE CHISESI NFS. MD. PHD.
Opioid Use Disorder, Chronic Pain
Computer Based Treatment for Cognitive Behavioral Therapy and Cooperative Pain Education and Self-Management
The investigators plan to develop and pilot test an integrated, web-based cognitive behavioral approach and then conduct a randomized clinical trial evaluating its efficacy relative to standard care in a large and diverse sample…
- Trial name
- IMPACT (NCT05204576)
- Testing
- CBT4CBT COPES
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- Yale University
Osteoarthritis, Knee
A Clinical Study to Investigate the Effect on Pain Relief of a Single Dose of JNJ-39439335 in Patients With Chronic Osteoarthritis Pain of the Knee
The purpose of this single-center study is to evaluate the potential analgesic effects of a single oral dose (50 mg) of JNJ-39439335, an investigational drug being developed for the treatment of pain in patients with chronic…
- Trial name
- NCT00933582
- Volunteers
- 33 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Chronic Pain, Neuralgia
GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain
The broad aim of the study is to implement and evaluate the efficacy of Graded Exposure Treatment (GET Living) to target elevated pain-related fears in children with chronic pain.
- Conditions
- Chronic Pain, Neuralgia, Musculoskeletal Pain, Headache
- Trial name
- GET Living (NCT01974791)
- Testing
- GET Living
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Boston Children's Hospital
Chronic Pain
Validating and Evaluating the Pain Medicine Digital Workflow Algorithm (PGS 1.0)
This is a prospective, non-randomized, double blind, single center, single arm, validation study, to evaluate the performance of PGS 1.0 algorithm in analyzing pain specific symptoms and medical history data of pain patients…
- Trial name
- NCT07195162
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- PG Medical Systems Ltd.
Chronic Non-malignant Pain
Pain Program for Active Coping & Training
The overall aim of this study is to adopt an integrative rehabilitation approach for helping patients adopt self-management skills for managing chronic pain, limiting use of opioid medications, and identifying exacerbating…
- Trial name
- PPACT-UH2 (NCT01888146)
- Testing
- Interdisciplinary pain program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente
Heel Spur
Comparative Effects of TherapeuticU and Shockwave Therapy on Pain and QOL in Patients With Chronic Heel Spur Pain
This research aims to compare the effectiveness of therapeutic ultrasound (TUS) and extracorporeal shockwave therapy (ESWT) in managing chronic heel spur pain and improving patients' quality of life.
- Trial name
- NCT06983457
- Testing
- Therapeutic ultrasound, Shockwave Therapy
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- Superior University
End Stage Renal Disease (ESRD)
Effect of PMR on Pain In Patients With ESRD
Background: Patients with chronic end-stage renal disease (ESRD) commonly experience chronic pain, which significantly impair their quality of life.
- Trial name
- NCT07061028
- Testing
- Progressive Muscle Relaxation, Control Group
- Where
- Jordan
- Volunteers
- 104 people
- Sponsor
- Jordan University of Science and Technology
Posttraumatic Stress Disorder, Traumatic Brain Injury
An Exploration of the Relationship Between Chronic Pain and Suicide Attempt Among Veterans
The purpose of this study is to explore the relationship between attempted and/or completed suicide and reported experience of chronic pain among an adult veteran population.
- Conditions
- Posttraumatic Stress Disorder, Traumatic Brain Injury, Suicide Attempt
- Trial name
- NCT01502436
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Rheumatic Arthritis, Chronic Pain
Effect of Home-Based Transcranial Direct Current Stimulation on Pain in Patients With Rheumatoid Arthritis With Low Inflammatory Activity
Rheumatoid arthritis (RA) is a highly complex inflammatory autoimmune disease. Several drugs have been developed in recent decades to target the immune components of inflammation.
- Trial name
- tDCS RA (NCT07162311)
- Testing
- tDCS
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Liver Cancer
Efficacy of TEAS on Chronic Pain and Survival in Patients Undergoing Hepatectomy
This study is a further observation and follow-up of the patients enrolled in the registration number NCT06341270 to further evaluate the efficacy of TEAS on postoperative chronic pain, quality of life and survival rate in…
- Trial name
- NCT06406244
- Testing
- TEAS group
- Where
- China
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Anesthesia, Analgesia
Pectoral Nerve Block II and Erector Spine Plane Block in Breast Cancer Surgery
This study evaluates the analgesic effects of pectoralis nerve block (PECS II) and erector spinae plane block (ESP) in patients having segmental mastectomy and sentinel lymph node biopsy (SLNB).
- Conditions
- Anesthesia, Analgesia, Acute Pain, Chronic Pain
- Trial name
- NCT04135157
- Testing
- Pectoralis nerve block II, Erector spine plane block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ondokuz Mayıs University
Chronic Low-back Pain, Chronic Pain
Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity
Participants with chronic pain conditions including chronic low back pain and fibromyalgia may benefit from light stimuli presented to the retina to reduce chronic pain severity and pain sensitivity.
- Conditions
- Chronic Low-back Pain, Chronic Pain, Fibromyalgia
- Trial name
- NCT05956067
- Testing
- Green Light stimulation, Equal Energy White stimulation, S-cone modulating white light
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System
Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases
Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases).
- Trial name
- NCT06942611
- Testing
- transcranial electrical stimulation treatment.
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Gonarthrosis; Primary, Genicular Nerve Block
Genicular Nerve Block in Chronic Knee Osteoarthritis
The goal of this clinical trial is to evaluate whether genicular nerve block (GNB) is effective in reducing pain in patients with knee osteoarthritis. It will also assess the comparative efficacy of different injection protocols.
- Conditions
- Gonarthrosis; Primary, Genicular Nerve Block, Gonarthritis
- Trial name
- GNB-KOA-RCT (NCT07174167)
- Testing
- Genicular nerve block with prilocaine, genicular nerve block with prilocaine and triamcinolone
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Back Pain Lower Back Chronic
Evaluation of the Short-term Effectiveness of Spinal Manipulation to Treat Acute and Subacute Low Back Pain.
Low back pain is the second most common reason for medical consultation in France and affects 60 to 80% of the working population.
- Trial name
- MeLoPe (NCT07403500)
- Testing
- Spinal or peripheral manipulation of the lower back to treat lower back pain
- Where
- France
- Volunteers
- 416 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Low Back Pain, Opiate Addiction
Study of Opioid Use After Lumbar and Cervical Spine Surgery
The purpose of this project is to assess the impact of an educational video on the use of prescription opioid medication during a 6-month period following spine surgery.
- Conditions
- Low Back Pain, Opiate Addiction, Neck Pain
- Trial name
- SOULCS (NCT02674711)
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
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