Clinical trials: Pain, Chronic Disease
Cystitis, Interstitial, Chronic Pain
Safety and Preliminary Efficacy of Endoscopic Submucosal Injection of Hyaluronic Acid Into the Bladder Wall in Patients With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
The goal of this pilot clinical trial is to learn if injecting hyaluronic acid into the bladder wall is safe and if it works to reduce pain and urinary frequency in people with interstitial cystitis (IC), also called bladder pain…
- Trial name
- HA-IC/BPSPilot (NCT07658118)
- Testing
- Hyaluronic Acid (HA)
- Volunteers
- 15 people
- Sponsor
- Sverdlovsk Regional Clinical Hospital No.1
Neck Pain Chronic, Insomnia Chronic
Effect of Acupuncture on Chronic Nonspecific Neck Pain and Insomnia
The study aims to assess the efficacy and safety of acupuncture among patients with chronic nonspecific neck pain and insomnia, compared with sham acupuncture.
- Trial name
- NCT06996210
- Testing
- Acupuncture
- Volunteers
- 124 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Chronic Spine Pain, Fibromyalgia
Resilience Skills Self-Management for Chronic Pain.
The investigators will conduct a randomized controlled trial of an 8-week resilience-enhanced CBT online self-management program for chronic pain plus usual care (PRISM), standard e-CBT self-management plus usual care (e-CBT)…
- Trial name
- NCT03304613
- Testing
- Web-based Cognitive Behavioral Therapy (e-CBT) Self-Management, Promoting Resilience through Innovative Self-Management
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Fibromyalgia
LET for Fibromyalgia
The study is a double blinded, randomized, sham-controlled, parallel group trial conducted at UT Southwestern (UTSW) Medical Center.
- Trial name
- NCT07201818
- Testing
- Lymphatic Enhancement Technology (LET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Pain, Neuropathic Pain
Neuronal Activation Accuracy in Closed-loop Spinal Cord Stimulation
Observational, prospective, single-center to assess neuronal activation accuracy and stimulation sensation in patients with closed-loop spinal cord stimulation therapy.
- Conditions
- Chronic Pain, Neuropathic Pain, Persistent Spinal Pain Syndrome Type 2
- Trial name
- NAA (NCT06775535)
- Testing
- ECAP-controlled, closed-loop SCS
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Karel Hanssens
Osteoarthritis, Chronic Pain
Imaging Pain Relief in Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease and is the most common form of arthritis. Pain reduction and functional recovery are the key elements of the clinical management of OA.
- Trial name
- IPRO (NCT02208778)
- Testing
- Duloxetine, Remifentanil
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University of Nottingham
Endometriosis, Endometriosis Related Pain
Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.
The main objective of this study is to know if the application of both therapies, neuroscience pain education plus therapeutic exercise will modify pain, catastrophizing and quality of life in endometriosis.
- Conditions
- Endometriosis, Endometriosis Related Pain, Endometriosis, Pain, Endometriosis-related Pain
- Trial name
- NCT06795243
- Testing
- PAIN NEUROSCIENCE EDUCATION AND THERAPEUTIC EXERCISE PROGRAM, USUAL CARE
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- University of Seville
TMD
Pain Neuroscience Education, Motor Imagery and Action Observation in Patients With Chronic Temporomandibular Disorders.
The objective of this study will be to verify the additional effect of Pain Neuroscience Education, Motor Imagery and Action Observation on primary outcomes pain intensity and craniofacial pain and disability in patients with…
- Trial name
- NCT05003349
- Testing
- Occlusal Splint (OS)., Pain Neuroscience Education (PNE)., Motor Imagery (MI).
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- University of Gran Rosario
Fibromyalgia
Prolonged Nightly Fasting in Fibromyalgia
The present randomized-controlled pilot trial will test the feasibility, acceptability, and preliminary efficacy of an 8-week prolonged nightly fasting (PNF) intervention protocol in 20 adults with fibromyalgia.
- Trial name
- NCT05581849
- Testing
- Prolonged Nightly Fasting, Health Education Control
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Arizona State University
Chronic Pain Syndrome, Peripheral Neuropathic Pain
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain
Neuropathic pain is frequent and drugs relieves only 50% of the patients. Repetitive transcranial magnetic stimulation (rTMS) at high frequency (HF, usually 10Hz) applied on the primary motor cortex (M1) is an effective treatment…
- Trial name
- CSA3-RTMS (NCT06964243)
- Testing
- transcranial magnetic stimulation (TMS)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Institut pour la Pratique et l'Innovation en PSYchologie appliquée (Institut Pi-Psy)
Endometriosis
ENDOMET - Novel Diagnostic Tools and Treatments for Endometriosis
Endometriosis is a chronic disease characterized by the presence of functional endometrial glands and stroma in ectopic locations outside the uterine cavity.
- Trial name
- ENDOMET (NCT01301885)
- Testing
- Laparoscopy/laparotomy
- Where
- 4 sites in Finland
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Fibromyalgia
Safety Study of DS-5565 for Treatment of Fibromyalgia Pain in Subjects With Chronic Kidney Disease
DS-5565 (mirogabalin) is being studied as treatment for fibromyalgia (FM) pain. Because it is excreted through the kidneys, people who have reduced kidney function will not process the drug as well as with those with normal…
- Trial name
- NCT02496884
- Testing
- DS-5565
- Where
- 39 sites in United States, Bulgaria and 6 more
- Volunteers
- 56 people
- Sponsor
- Daiichi Sankyo
Breast Cancer, Anesthesia
Opioid-free Anaesthesia in Breast Cancer Surgery
Background: Various analgesic modalities are adopted for perioperative analgesia in breast cancer surgeries. Opioid-free and opioid-sparing techniques are gaining popularity due to the lack of opioid-dependent undesirable…
- Conditions
- Breast Cancer, Anesthesia, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06404983
- Testing
- Opioid Free Anaesthesia (OFA), Conventional General Anaesthesia (CGA)
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Ioannina
Chronic Illness, Chronic Pain
Treating Comorbid Depression During Care Transitions Using Relational Agents
Depression is common among individuals with chronic illness such as chronic heart failure (CHF) or chronic obstructive pulmonary disease (COPD) and is a strong predictor of poor clinical outcomes and high rates of avoidable…
- Conditions
- Chronic Illness, Chronic Pain, Depression, Comorbid Depression
- Trial name
- RA-CBT (NCT02845102)
- Testing
- Pre-Post Feasibility
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Interstitial Cystitis, Chronic Prostatitis
Trans-MAPP II Study of Urologic Chronic Pelvin Pain
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has been established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health…
- Trial name
- NCT02898220
- Where
- 6 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Arthritis, Rheumatoid, Pain
Chronic Pain in Rheumatoid Arthritis
The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis.
- Trial name
- CPIRA-2 (NCT05038553)
- Testing
- No intervention
- Where
- 5 sites in United States
- Volunteers
- 125 people
- Sponsor
- Northwestern University
Cardiometabolic Risk Factors
Physical Exercise on Physiological Adaptation Capacity and Chronic Pain in Individuals With Cardiovascular Risk
This research focuses on studying the effects of a 12-week exercise program on the health of individuals at risk of heart disease.
- Trial name
- NCT06201273
- Testing
- High-Intensity Interval Training, Resistance Training
- Where
- Chile
- Volunteers
- 192 people
- Sponsor
- Universidad San Sebastián
Fibromyalgia
Fibromyalgia Sleep A to ZZZ Study
This research study is testing whether changes in sleep timing and morning light therapy may have an impact on symptoms related to fibromyalgia.
- Trial name
- NCT06567886
- Testing
- Light Therapy, Sleep Stabilization
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- University of Michigan
TMD/Orofacial Pain, Fibromyalgia (FM)
Diagnostic and Prognostic Salivary Biomarkers in Chronic Muscle Pain
A large proportion of the adult population worldwide currently lives with chronic muscle pain, with more than half of those affected experiencing pain localized to the face and jaw.
- Trial name
- NCT06994156
- Where
- Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
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