Clinical trials: Pain, Chronic Disease
Chronic Pain, Temporomandibular Disorder
An Internet-based Multimodal Pain Program for Chronic Temporomandibular Disorder Pain
Background Chronic temporomandibular disorders (TMD) pain is an undertreated condition in Sweden despite the fact that national guidelines includes effective treatment options.
- Trial name
- NCT04363762
- Testing
- Internet-based multimodal pain program, Occlusal splint
- Volunteers
- 40 people
- Sponsor
- Malmö University
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Chronic Back Pain, Opioid Use
Adaptations of the Brain in Chronic Pain With Opioid Exposure I
This study investigates brain reorganization and behavioral responses in chronic pain with opioid exposure in Chronic Back Pain (CBP).
- Trial name
- NCT05203770
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Knee Pain Chronic, Rheumatoid Arthritis
Cemented vs Cementless Persona Keel RCT
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
- Conditions
- Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT05630053
- Testing
- Cementless Persona Knee System, Cemented Persona Knee System
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Opioid-use Disorder, Medication Assisted Treatment
Psychosocial Pain Management to Improve Opioid Use Disorder Treatment Outcomes
The purpose of this research study is to look at the effect of programs aimed at helping people manage chronic pain and medication treatment.
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Chronic Pain
- Trial name
- Persist (NCT04433975)
- Testing
- Psychosocial Pain Management (PPMI), Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Stable Chronic Angina, Ischemic Heart Disease
Effect of Tertiary A-level Hospital Remote Intervention on MACCE, Adherence to Drugs and Risk Factors Control in Patients With Stable Coronary Artery Disease Compared With Traditional Community Hospital Follow-up
The study was a multicenter, two-arm, parallel, open label, prospective study intended for to compare effect of offline community hospital intervention on adherence to drugs and risk factors control in patients with stable…
- Conditions
- Stable Chronic Angina, Ischemic Heart Disease, Acute Coronary Syndrome
- Trial name
- CHIPCHAT (NCT04795505)
- Testing
- Intervention, Control
- Where
- China
- Volunteers
- 1,424 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Juvenile; Scoliosis, Scoliosis Idiopathic
Studying Melatonin and Recovery in Teens
The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgerySMART (NCT06093477)
- Testing
- Fast-Dissolve Melatonin Pill
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Chronic Pain, Complex Regional Pain Syndrome
Effects of Spinal Cord Stimulation on Sensory Perceptions of Chronic Pain Patients
It's well known that Spinal cord stimulation (SCS) changes the perception of chronic pain in the area stimulated by epidural electrodes.
- Conditions
- Chronic Pain, Complex Regional Pain Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT02837822
- Testing
- Spinal cord stimulator, Implantation of a spinal cord stimulator
- Where
- 2 sites in United States, Canada
- Volunteers
- 38 people
- Sponsor
- CHU de Quebec-Universite Laval
Gastrointestinal Disorders, Functional
Web-based Management of Pediatric Functional Abdominal Pain
Functional abdominal pain (FAP), a pediatric pain condition without significant organic pathology, is a precursor to chronic pain and high healthcare utilization in young adulthood.
- Trial name
- NCT02327377
- Testing
- Online Cognitive Behavior Therapy, Online Education
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Low Back Pain, Spinal Cord Injury
SERENITY Study of Chronic Pain Interference in Adults
SERENITY is a remote observational study designed to characterize inter-individual differences in chronic pain among adults with chronic low back pain and adults with spinal cord injury-related neuropathic pain.
- Conditions
- Chronic Low Back Pain, Spinal Cord Injury, Neuropathic Pain, Chronic Pain
- Trial name
- SERENITY (NCT07820475)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Chronic Pain, Neuralgia
Acupuncture Versus Conventional Treatment for Chronic Pain in Patients With Chronic Kidney Disease
This study evaluated acupuncture plus optimized conventional pharmacological treatment compared with optimized conventional pharmacological treatment alone for chronic pain in adults with chronic kidney disease receiving…
- Conditions
- Chronic Pain, Neuralgia, Renal Insufficiency,Chronic
- Trial name
- NCT07891819
- Testing
- Acupuncture, Optimized conventional pharmacological treatment
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of São Paulo
Complex Regional Pain Syndromes, Fibromyalgia
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
Motor neglect describes a loss of function without a loss of strength, reflexes or sensation. Motor neglect has been described in patients with traumatic brain injury, stroke and chronic pain conditions, e.g.
- Conditions
- Complex Regional Pain Syndromes, Fibromyalgia, Stroke, Traumatic Brain Injury
- Trial name
- VERMONT (NCT03887962)
- Testing
- Virtual Environment Biofeedback, Treadmill walking with no Virtual Environment Biofeedback
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Low Back Pain, Migraine
Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain
The purpose of this study is to evaluate the safety and tolerability of OraVescent fentanyl for the potential treatment of breakthrough pain episodes in patients who have chronic noncancer pain.
- Conditions
- Low Back Pain, Migraine, Diabetic Neuropathies, Osteoarthritis
- Trial name
- NCT00228605
- Testing
- OraVescent Fentanyl
- Where
- 38 sites in United States
- Volunteers
- 500 people
- Sponsor
- Cephalon
Interstitial Cystitis, Chronic Prostatitis
Trans-MAPP II Study of Urologic Chronic Pelvin Pain
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has been established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health…
- Trial name
- NCT02898220
- Where
- 6 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pain, Chronic, Pain, Neuropathic
Caregiver Burden and Correlation With Clinical Outcome in Spinal Cord Stimulation for Chronic Neuropathic Pain
Prospective multicentric observational trial on caregiver burden, caregiver satisfaction and clinical outcome in spinal cord stimulation for chronic neuropathic pain.
- Conditions
- Pain, Chronic, Pain, Neuropathic, Failed Back Surgery Syndrome
- Trial name
- CAREstim (NCT04737746)
- Where
- 2 sites in Belgium
- Volunteers
- 42 people
- Sponsor
- AZ Delta
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Cervical Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of lidocaine and ketamine in the same syringe versus remifentanyl analgesia in cervical spine…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05717361
- Testing
- ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Pain, Chronic
Using Immersive Virtual Reality to Treat Complex Regional Pain Syndrome in Adults
This study is designed to test if the use of virtual reality (VR) can improve chronic pain related to CRPS. One way is to use virtual reality.
- Trial name
- NCT05888142
- Testing
- in clinic pain VR reduction exercises, In clinic VRpain reduction exercises + VR homeworks
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Washington
Head Cancer, Neck Cancer
Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)
Following preliminary studies carried out in our department on these subject and subjective findings during clinical examinations, it has been shown that pain is a symptom that is rarely reported following treatment.
- Conditions
- Head Cancer, Neck Cancer, Chronic Pain
- Trial name
- OCAPA (NCT04673981)
- Testing
- diagnostic tes for neuropathic pain
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System
Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases
Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases).
- Trial name
- NCT06942611
- Testing
- transcranial electrical stimulation treatment.
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
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