Clinical trials: Pain, Chronic Disease
Chronic Low-back Pain
Breathing and Attention Training for Chronic Low Back Pain
The purpose of this research study is to see if breathing and attention training (BAT) treatments improve pain symptoms and well-being in people who have chronic low back pain (cLBP).
- Trial name
- NCT04740710
- Testing
- Breathing and Attention Training
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Florida
Chronic Interstitial Cystitis, Painful Bladder Syndrome
Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder
Pilot study to determine feasibility for treating patients with two chronic inflammatory conditions of the urinary bladder: chronic interstitial cystitis and recurrent urinary tract infections using a standardized hyperbaric…
- Conditions
- Chronic Interstitial Cystitis, Painful Bladder Syndrome, Recurrent Urinary Tract Infection
- Trial name
- HBOTCICrUTI (NCT03143920)
- Testing
- Hyperbaric Oxygen Therapy-
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, San Diego
Opioid-induced Constipation
Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.
This study will evaluate the safety and efficacy of Tegaserod in opioid-induced constipation in patients with non-cancer pain. Patients who enter this study PRIOR to the core study (CHTF919N2201) interim analysis receive the…
- Trial name
- NCT00414024
- Testing
- Tegaserod
- Where
- 6 sites in United States, China and 4 more
- Volunteers
- 11 people
- Sponsor
- Novartis
Graft vs Host Disease
Dexamethasone to Prevent Oral Chronic Graft-versus-Host Disease
This study will determine if a dexamethasone mouth rinse can reduce the risk of developing oral chronic graft-versus-host disease (cGVHD) in patients who have undergone a bone marrow (stem cell) transplant procedure.
- Trial name
- NCT00391170
- Testing
- Topical Dexamethasone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Obesity, Abdominal
Impact of the Use of FeelWell™ Compression Garment on Individuals With a BMI ≥35
To assess the effect of wearing a custom-fitted, FDA-registered, Class I device, compression garment (Obesinov, S.A.R.L.) by an individual with a BMI ≥ 35 on his/her day-to-day quality of life over a period of one year.
- Conditions
- Obesity, Obesity, Abdominal, Mobility Limitation, Quality of Life
- Trial name
- NCT03798873
- Testing
- FeelWell™ Compression garment, Increase Mobility
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Feelwell Compression
Spinal; Nerve Root, Pain, Pelvic Pain
Quality of Life and Pain Changes Due to DRG Stimulation for Chronic Pain
ACTIVE study- a prospective observational clinical study examining the changes in quality of life and pain following dorsal root ganglion stimulation for the treatment of chronic intractable pelvic and lower limb pain.
- Conditions
- Spinal; Nerve Root, Pain, Pelvic Pain, Regional Pain Syndrome, Chronic Pain Syndrome
- Trial name
- ACTIVE (NCT03417973)
- Testing
- dorsal root ganglion neuromodulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- KM Clinical Research Group
Chronic Pain, Schizophrenia
CBT-CP for Veterans With SMI
Chronic musculoskeletal pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic musculoskeletal pain leads to poorer mental and physical health-related functioning, representing…
- Conditions
- Chronic Pain, Schizophrenia, Psychotic Disorders, Bipolar Disorder
- Trial name
- CP-SMI (NCT06758414)
- Testing
- Cognitive Behavioral Therapy for Chronic Pain (CBT-CP), Health & Wellness (H&W)
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- VA Office of Research and Development
Inguinal Hernia, Laparoscopic Surgery
Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy
Background: Large acceptance of mesh reinforcement techniques in groin hernia repair lowered recurrence rates for all techniques. Recurrence rate alone is not the main quality criterion for hernia repair anymore.
- Conditions
- Inguinal Hernia, Laparoscopic Surgery, Pain, Sexual Dysfunction, Physiological
- Trial name
- GENINGHERNIA (NCT00625534)
- Testing
- Laparoscopic totally extraperitoneal inguinal hernia repair, Open tension free inguinal hernia mesh repair
- Where
- Switzerland
- Volunteers
- 260 people
- Sponsor
- University Hospital, Geneva
Anxiety Disorders and Symptoms, Fibromyalgia
The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature
Herbal Medicine is known as the medicinal use of herbal substances as a means of treating different conditions in the human body to ensure that the body remains in optimal health and wellness.
- Conditions
- Anxiety Disorders and Symptoms, Fibromyalgia, Arthritis, Chronic Pain
- Trial name
- NCT05067998
- Testing
- IV Vitamin Infused Therapy Treatment, Herbal medicine
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Faith A. Richardson
Chronic Stable Angina
Danhong Injection in the Treatment of Chronic Stable Angina
The purpose of this study is to evaluate the effect of Danhong Injection on the relief of angina with the use of the Seattle Angina Questionnaire among patients with stable angina patients
- Trial name
- NCT01681316
- Testing
- Danhong injection, Standard medical care
- Where
- 31 sites in China
- Volunteers
- 920 people
- Sponsor
- China Academy of Chinese Medical Sciences
Pelvic Pain, Endometriosis
Personalized Exercise Recommendations for Chronic Pelvic Pain Using Reinforcement Learning
WorkoutCPP is a pilot study evaluating the feasibility of a personalized exercise recommendation system for individuals with chronic pelvic pain disorders (CPPDs).
- Conditions
- Pelvic Pain, Endometriosis, Chronic Pelvic Pain
- Trial name
- WorkoutCPP (NCT07810218)
- Testing
- Reinforcement Learning (RL)-Based Personalized Exercise Recommendations, Generic Exercise Recommendation
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteoarthritis, Arthritis, Rheumatoid
Low Dose Naltrexone for Chronic Pain From Arthritis
Over 100 million Americans report chronic pain. Veterans are disproportionately affected for multiple reasons, including injuries and post-traumatic stress disorder.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- LDN-VA (NCT03008590)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain
This phase I trial evaluates the side effects of psilocybin and how well it works under supportive care conditions in cancer survivors living with demoralization and chronic pain.
- Trial name
- NCT05506982
- Testing
- Psilocybin, Psychotherapy, Quality-of-Life Assessment
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Emory University
Chronic Pain, Musculoskeletal Pain
Multicomponent Exercise and Pain Science Education for Fall Prevention in Older Adults With Chronic Musculoskeletal Pain (MovePainFall)
Chronic musculoskeletal pain is common in older adults and is associated with reduced mobility, loss of function, poorer quality of life, fear of movement, fear of falling and a higher risk of falls.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Accidental Falls, Fear of Falling
- Trial name
- MovePainFall (NCT07889024)
- Testing
- MovePainFall multicomponent exercise programme, Pain science and fall-prevention education
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Instituto Politécnico de Bragança
Dyspareunia (Female Excluding Psychogenic), Female Sexual Dysfunction (FSD)
Effect of Respiratory Exercises With Pelvic Floor Rehab on Dyspareunia & Autonomic Function in Women
Background and Aim: Dyspareunia, or pain during sexual intercourse, is a common component of female sexual dysfunction and may have multifactorial origins, including musculoskeletal and autonomic factors.
- Conditions
- Dyspareunia (Female Excluding Psychogenic), Female Sexual Dysfunction (FSD), Chronic Pelvic Pain
- Trial name
- Dyspareunia (NCT07078318)
- Testing
- Pelvic floor rehabilitation, Diaphragmatic Breathing Exercises, Diaphragm Manual Therapy
- Volunteers
- 45 people
- Sponsor
- Sakarya Applied Sciences University
Arthroplasty, Replacement Material
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when…
- Conditions
- Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- CRYO-TKA (NCT07425457)
- Testing
- CT-guided Cryoneurolysis of the Genicular Nerves
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Chronic Pain
Virtual Intelligence for Transformative Lifestyle Solutions in Pain
This pilot study aims to evaluate the feasibility and acceptability of a VR-based chronic pain management intervention with a virtual AI coach for patients with Opioid misuse and opioid use disorder (OM/OUD).
- Trial name
- VITALS-Pain (NCT07124598)
- Testing
- VR Headset Device - Meta Quest 3
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Montefiore Medical Center
Chronic Musculoskeletal Pain, Veterans
Stepped-Care Intervention of Music and Imagery to Assess Relief (SCIMITAR) Trial
Th Stepped-Care Intervention of Music and Imagery to Assess Relief (SCIMITAR) Trial. SCIMITAR builds on our pilot study, the Feasibility and Acceptability of Music Imagery and Listening Interventions for Analgesia (FAMILIA)…
- Conditions
- Chronic Musculoskeletal Pain, Veterans, Music Therapy
- Trial name
- SCIMITAR (NCT07217821)
- Testing
- Stepped-care
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Endometriosis, Pelvic Pain Syndrome
Study on the Outcomes of Patients Treated in Gynecological Emergency Departments for Pelvic Endometriosis or Suspected Pelvic Endometriosis
Adult patients consulting the gynecological emergency department of CHI Créteil during the inclusion period for endometriosis or symptoms suggestive of endometriosis
- Conditions
- Endometriosis, Pelvic Pain Syndrome, Chronic Gynaecological Disease
- Trial name
- NCT07472842
- Testing
- Emergency care for endometriosis
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Low Back Pain, Chronic Disease
Myofascial Release and Kinesio Taping on Autonomic Nervous System in Low Back Pain
The purpose of this current randomized clinical trial is to determine the effects of myofascial soft tissue release and kinesio taping on disability, pain, quality of life, autonomic nervous system and oxidative stress indicators…
- Trial name
- I (NCT02067494)
- Testing
- Myofascial Soft Tissue Release, Kinesio taping treatment
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Universidad de Almeria
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