Clinical trials: Pain, Chronic Disease
Sickle Cell Disease
Home-Based Intervention for Chronic Pain in Adults With Sickle Cell Disease
This project will evaluate AppliedVR's EaseVRx - a multi-modal, skills-based, 8-week, virtual reality, home intervention - in an exploratory randomized controlled trial for self-management of chronic pain among Black, young…
- Trial name
- NCT04906707
- Testing
- EaseVRx, Audio-only version of EaseVRx
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Emory University
Chronic Low-back Pain, Insomnia
Mobile App-delivered Sleep Therapy (SleepFix) for Individuals With Chronic Low Back Pain and Insomnia
The goal of this clinical trial is to assess the efficacy of a digital behavioral therapy for insomnia (dBTi) in people with chronic low back pain and insomnia.
- Trial name
- SleepBack (NCT05846087)
- Testing
- sleep retraining therapy, sleep health education modules
- Where
- Australia
- Volunteers
- 106 people
- Sponsor
- Woolcock Institute of Medical Research
Low Back Pain
Influence of Kinesiophobia on the Outcome of Chronic Low Back Pain Condition
Though large body of evidence reported association between pain and kinesiophobia, there are paucity of studies in associating kinesiophobia to muscle endurance and position sense in patients with Chronic lower back pain [CLBP].
- Trial name
- NCT05079893
- Testing
- Case control study
- Volunteers
- 600 people
- Sponsor
- Gulf Medical University
Hip Osteoarthritis, Hip Pain Chronic
Continuous Radiofrequency in Hip Osteoarthritis Pain: A Randomized Clinical Trial.
This will be a prospective, single-center, double-blinded, randomized study designed to compare the efficacy of the intraarticular injection of a corticosteroid and the Conventional Radiofrequency (CRF) of the anterior sensory…
- Trial name
- NCT06221709
- Testing
- Conventional Radiofrequency (CRF group), Intraarticular Infiltration ( Control group)
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Brasilia
Chronic Low Back Pain, Degenerative Disc Disease
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms
Opioids are frequently prescribed for chronic low back pain (CLBP). Psychiatric illness, such as high levels of depression and anxiety symptoms, is a common co-occurrence in chronic pain patients (and is termed comorbid negative…
- Conditions
- Chronic Low Back Pain, Degenerative Disc Disease, Depression, Anxiety
- Trial name
- NCT01502644
- Testing
- Oxycodone, Morphine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Brigham and Women's Hospital
Musculoskeletal Pain, Chronic Pain
Immediate and Mid-term Effect of a Natural Topical Product in Patients With Musculoskeletal Pain
Musculoskeletal pain is a common affection due to ageing, sedentarism and intense exercise practice causing acute and chronic injuries.
- Conditions
- Musculoskeletal Pain, Chronic Pain, Joint Pain, Stiffness of Unspecified Joint, Not Elsewhere Classified
- Trial name
- NCT04683263
- Testing
- Fisiocrem
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Uriach Consumer Healthcare
Myofascial Pain Syndrome - Neck
Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial Pain
This study aims to investigate how closely two approaches to assessing pain-related characteristics agree in adults with chronic cervical myofascial pain syndrome (chronic neck pain associated with painful muscle trigger points).
- Trial name
- NCT07904364
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Mardin Artuklu University
Fibromyalgia (FM)
Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia
The first goal of this study is to see how brain activity changes in people with fibromyalgia after they get a treatment called rTMS (repetitive transcranial magnetic stimulation).
- Trial name
- rTMS (NCT07260864)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Neck Pain, Cervical Radiculopathy
Paramedian CESI vs Selective Nerve Root PRF for Lower Cervical Radicular Pain
This study aims to compare the efficacy of ultrasound-guided selective cervical nerve root pulsed radiofrequency (PRF) versus fluoroscopy-guided paramedian cervical epidural steroid administration (CESI) for the treatment of…
- Trial name
- NCT05950321
- Testing
- Paramedian cervical epidural steroid injection, Selective nerve root pulsed radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Osteoarthritis (OA)
HypnoPain Relief for OA
The goal of this clinical trial is to learn whether HypnoPain Relief (HPR), a brief clinical hypnosis intervention, can help reduce pain and improve quality of life in adults with osteoarthritis.
- Trial name
- HPR (NCT07850271)
- Testing
- HypnoPain Relief (HPR), Neutral Visual Exposure Waitlist Control
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Gadjah Mada University
Endometriosis, Chronic Pelvic Pain
Ketamine in Central Sensitization
The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA.
- Trial name
- NCT07182032
- Testing
- ketamine
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Chronic Respiratory Diseases
Interest of Cryotherapy in Reducing Pain During Radial Arterial Blood Sampling
Arterial puncture for blood gas analysis is a diagnostic procedure used to assess arterial blood gases and monitor a patient's oxygenation status.
- Trial name
- HOURRA (NCT07408011)
- Testing
- Apllication of medical device ice pack, Apllication of cream
- Where
- 2 sites in France
- Volunteers
- 258 people
- Sponsor
- University Hospital, Brest
Cancer Breast, Chronic Pain Syndrome
Magnesium Sulphate to Bupivicaine in Serratus Anterior Plane Block in Modified Radical Mastectomy
Modified radical mastectomy may be associated with severe post-operative pain, leading to chronic pain syndrome which usually requires optimal perioperative pain management.
- Trial name
- NCT04429893
- Testing
- magnesium sulphate, bupivicaine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Chronic Pain, Low Back Pain
A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain
The primary objective of the study is to determine the analgesic efficacy and safety of ALO-02 extended-release capsules, when compared to placebo, in subjects with moderate to severe chronic low back pain.
- Conditions
- Chronic Pain, Low Back Pain, Analgesia
- Trial name
- NCT01571362
- Testing
- ALO-02
- Where
- 52 sites in United States
- Volunteers
- 410 people
- Sponsor
- Pfizer
Neuropathic Pain
Electroencephalographic (EEG) Profils for Patients on Intravenous Ketamine.
Chronic pain symptoms can lead to sleep and mood disorders, restrict domestic and work activities and have a significant impact on quality of life.
- Trial name
- KetEEG (NCT05949554)
- Testing
- Ketamine infusion
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain, Crohn Disease
Group ACT for CD Pain- a Feasibility Study
Pain is a common symptom of inflammatory bowel disease (IBD) and has a significant impact on patient quality of life. Pain will frequently be the presenting complaint and is experienced throughout the disease course.
- Trial name
- NCT05418062
- Testing
- Acceptance and commitment therapy (ACT)
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- King's College London
Post-Concussion Syndrome, Concussion, Brain
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old.
- Conditions
- Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury
- Trial name
- NCT06073886
- Testing
- Active cTBS, Imaginal exposure
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Chronic Daily Headache, Chronic Migraine
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal…
- Trial name
- NCT03231241
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Stanford University
Complex Regional Pain Syndromes
Investigation of the Efficacy of Transcranial Magnetic Stimulation in Patients Developing Complex Regional Pain Syndrome Type 1 in the Upper Extremity During the Subacute-Chronic Period After Ischemic Stroke
The aim of our study is to investigate transcranial magnetic stimulation (TMS) as a treatment option in Complex Regional Pain Syndrome, disseminate it to a broader patient population, and simultaneously demonstrate its…
- Trial name
- NCT06215079
- Testing
- The Magstim Rapid2 Plus Magnetic Stimulator (Magstim, Whitland, Dyfed, UK), conventional rehabilitation program
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Pain, Chronic Pain
Efficacy and Safety of Spinal Cord Stimulation in Patients With Chronic Intractable Pain
The purpose of this study is to evaluate the efficacy and safety of spinal cord stimulation (SCS) using the PINS spinal cord stimulator device for chronic and intractable pain.
- Conditions
- Pain, Chronic Pain, Back Pain, Spinal Cord Stimulation
- Trial name
- NCT03858790
- Testing
- PINS Spinal Cord Stimulator
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Beijing Pins Medical Co., Ltd
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