Clinical trials: Pain, Chronic Disease
Chronic Low Back Pain
Influence of Cryotherapy Combined to TENS Burst in Patients With Non-specific Chronic Lombar Pain
The purpose of this study is to analyze the effects of TENS Burst combined Cryotherapy on painful sensation, functional capacity and quality of life of patients with non-specific chronic pain.
- Trial name
- NCT03111199
- Testing
- Cryotherpy, TENS Burst, Education
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Wouber Hérickson de Brito Vieira
Sickle Cell Disease, Pain
Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease
Children with sickle cell disease may experience frequent painful episodes. This, together with the traumatic experiences during a hospitalization, can lead to the development of posttraumatic stress reactions.
- Conditions
- Sickle Cell Disease, Pain, Pain, Chronic Disease
- Trial name
- RELAX (NCT07001631)
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Neuropathic Pain, Nociceptive Pain
PET/MRI in the Diagnosis of Chronic Pain
Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain.
- Conditions
- Neuropathic Pain, Nociceptive Pain, Mixed Pain (Nociceptive and Neuropathic), Spinal Pain
- Trial name
- NCT03556137
- Testing
- [18F]FTC-146
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep Disorder; Breathing-Related, Pain
Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids
Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB).
- Conditions
- Sleep Disorder; Breathing-Related, Pain, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- PRESTO (NCT04928157)
- Testing
- Positive Airway Pressure (PAP)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pain
NS1209 and Lidocaine in Patients With Peripheral Neuropathic Pain
Purpose: To evaluate the efficacy, tolerability and safety of NS1209 compared to lidocaine and placebo in patients with peripheral chronic neuropathic pain.
- Trial name
- NCT00258622
- Testing
- NS1209, Lidocaine
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Danish Pain Research Center
Chronic Pain, Chronic Pain Syndrome
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP).
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia
- Trial name
- STTEPP (NCT05603702)
- Testing
- Lacosamide
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- Indiana University
COVID-19
Trial of Auricular Vagus Nerve Stimulation in Painful Covid Long
Patients infected with Covid 19 suffer from frequent pain (headache, migraines, joint pain, muscle pain) in the acute phase which may persist after a stay in intensive care or in an intensive care unit, in the event of…
- Trial name
- COLOSAT (NCT05205577)
- Testing
- Tens Eco Plus
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Social Functioning, Addiction, Substance
Pain Clinic Provides Public Health Safety
Chronic pain is associated with psychological disorders; which may affect a patient's socioeconomic, legal, domestic, and employment situations.
- Conditions
- Social Functioning, Addiction, Substance, Safety Issues, Road Injury
- Trial name
- NCT06076512
- Testing
- Behavioral therapy
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Healthy, Peripheral Neuropathic Pain
Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food-effect of TRK-750
This is an exploratory, randomised, double-blind, placebo-controlled, Phase I study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food-effect of single and multiple, ascending oral doses of TRK-750 in…
- Trial name
- NCT03346330
- Testing
- TRK-750
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Toray Industries, Inc
Chronic Pancreatitis, Chronic Pain
Extracorporeal Shock Wave Lithotripsy and Endotherapy for Pain in Chronic Pancreatitis
Pain is a common symptom of chronic pancreatitis and remains a significant therapeutic challenge. In patients with pathological changes of the pancreatic duct, including stones and strictures, endoscopic procedures with or…
- Trial name
- SCHOKE (NCT03966781)
- Testing
- ESWL, ERCP
- Where
- India
- Volunteers
- 106 people
- Sponsor
- Asian Institute of Gastroenterology, India
Breast Cancer, Chronic Pain Due to Malignancy (Finding)
Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients
Cancer in general, and breast cancer in specific, is a significant health problem in the USA and the rest of the world. With the improvement of new surgical approaches and chemotherapies to manage breast cancer, the number of…
- Trial name
- NCT03847311
- Testing
- Sulfasalazine
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Interstitial Cystitis, Bladder Pain Syndrome
Biopsychosocial and Conventional Approach in Bladder Pain Syndrome
The aim of the present study is to compare the effects of biopsychosocial and conventional approach on symptom severity, pain parameters (pain intensity and pain cognitions), disability, psychological distress and quality of life…
- Trial name
- NCT05155384
- Testing
- Pain Neuroscience Education, Relaxation exercises, Cognition target exercise
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Fibromyalgia
Effectiveness of Video-based Multicomponent Treatment for Fibromyalgia Plus Face-to-face Sesions in Nature or at Sea
The aim of this study was to examine the effectiveness of a video-based multicomponent program: the Fibrowalk Virtual plus face-to-face sessions for patients with fibromyalgia (FM) in nature or at sea (FM) compared to Fibrowalk…
- Trial name
- NCT05395832
- Testing
- TAU + multicomponent treatment VIRTUAL FIBROWALK + 4 face-to-face sessions at sea, TAU + multicomponent treatment VIRTUAL FIBROWALK + 4 face-to-face sessions in nature, TAU + multicomponent treatment VIRTUAL FIBROWALK
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Obstructive Pulmonary Disease
Symptom Clusters and Immune Markers in Patients With Chronic Obstructive Pulmonary Disease (COPD) - a Longitudinal Study
COPD patients often have a wide range of physical (e.g., dyspnea, fatigue, pain) and psychological (e.g., depression, anxiety) symptoms and various other debilitating conditions that cause considerable suffering for the…
- Trial name
- SGIS (NCT01016587)
- Where
- Norway
- Volunteers
- 275 people
- Sponsor
- Oslo University Hospital
CRPS, Chronic Regional Pain Syndrome
TNF-alpha Inhibition in CRPS: A Randomized Controlled Trial
Studying the effects of Etanercept (an anti-Tumor Necrosis Factor alpha) on early Chronic Regional Pain Syndrome (CRPS). Our hypothesis is that Etanercept will improve patient symptoms if given in early CRPS.
- Trial name
- NCT02031211
- Testing
- Etanercept
- Where
- United States
- Sponsor
- Stanford University
Chronic Pain, PTSD
Internet-Delivered Acceptance and Commitment Therapy (iACT) for Youth With PTSD and Chronic Pain
The primary aim of this study is to investigate the effect of Internet-delivered Acceptance and commitment therapy for youth with PTSD and comorbid chronic pain.
- Trial name
- NCT07813728
- Testing
- iACT
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Skane University Hospital
Chronic Pain, Post Intensive Care Unit Syndrome
The Post-ICU Pain Study
BACKGROUND: ICU survivors may experience serious psychological, physical and cognitive impairments following ICU admission, collectively termed Post Intensive Care Syndrome (PICS).
- Conditions
- Chronic Pain, Post Intensive Care Unit Syndrome, Quality of Life, Pain Disorder
- Trial name
- PIP (NCT07180407)
- Where
- 4 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Parkinson's Disease
Telemedicine Intervention in Patients With Chronic Pain in PD
Pain is a very common and disabling symptom in Parkinson's disease, yet it is often untreated. This study will assess the impact of home-based physical and cognitive exercise interventions to reduce pain in this disease.
- Trial name
- NCT05410392
- Testing
- Physical exercise intervention, Cognitive exercise intervention, Health education
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- VA Office of Research and Development
Chronic Coronary Syndrome, Chronic Coronary Total Occlusion
Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease
This study aim to investigate the association between plasma NT-proBNP levels and the presence, extent and severity of stenosis in patients with suspected coronary artery disease.
- Conditions
- Chronic Coronary Syndrome, Chronic Coronary Total Occlusion, Coronary Arterial Disease (CAD), Stable Chronic Angina
- Trial name
- BNP-CAD (NCT07013344)
- Testing
- BNP
- Where
- 2 sites in Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Ospedale San Raffaele
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