Clinical trials: Pain, Chronic Disease
Opiate Dependence, Chronic Pain
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
This study is designed to develop an effective psychotherapy for chronic pain and opioid dependence.
- Trial name
- POD (NCT00634803)
- Testing
- CBT, Buprenorphine, Educational Counseling
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
Neuropathic Pain, Chronic Pain
Ultrasound for Peripheral Nerve Modulation
This study evaluates an ultrasound device designed to reduce pain by targeting peripheral nerves without surgery or medication. The device is placed on the skin over the area of pain and delivers controlled ultrasound…
- Trial name
- NCT07572591
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Stanford University
Endometriosis
Whole-Body Cryotherapy as a Non-Pharmacological Treatment to Reduce Chronic Pelvic Pain and Improve Quality of Life in People With Endometriosis
The aim of this study is to investigate whether whole-body cryotherapy (a brief exposure to very cold temperatures) can help reduce pain and improve quality of life in people living with endometriosis, and whether it may…
- Trial name
- CHILL-Endo (NCT07603960)
- Testing
- Whole-Body Cryotherapy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Fibromyalgia
Effects of Breathing and Attention Training (BAT) on Pain Modulation
The hypersensitivity of fibromyalgia is associated with abnormal pain modulation within the CNS, but not with peripheral or central sensitization.
- Trial name
- NCT05773482
- Testing
- Breathing and Attention Training (BAT), Breathing Control
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Musculoskeletal Manipulations
Effects of Myofascial Release and TENS Over Pain, Hand Prehensile Strength and Functionality of Superior Extremity in Women With Lateral Epicondylalgia
This study evaluated the additive effect of myofascial release therapy on the brachial biceps on conventional management (TENS) in pain intensity, hand prehensile strength and upper limb functionality of individuals with lateral…
- Trial name
- NCT04023279
- Testing
- TENS, Myofascial therapy
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- Fernanda Merino Alvarez
Chronic Ischemic Heart Disease, Heart Failure
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy
Phase I-II Clinical Trial-Safety and efficacy of umbilical cord derived mesenchymal stem cells (UC-MSCs) in patients with chronic heart ischemia cohort and perspective study.
- Conditions
- Chronic Ischemic Heart Disease, Heart Failure, Angina
- Trial name
- UCMSC-Heart (NCT02439541)
- Testing
- UCMSC group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Plantar Fasciitis, Chronic
A Novel Approach to Plantar Fasciitis in the Aging Population
The goal of this study is to determine whether improving foot strength through foot exercises and minimal footwear can provide improved outcomes over the short and long term.
- Trial name
- NAPA (NCT05834491)
- Testing
- minimal shoes and foot strengthening and flexibility exercises, Supportive Footwear, foot orthotic device and foot flexibility exercises
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- University of South Florida
Chronic Pain, Drug Dependence of Morphine Type
Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal
The proposed clinical trial will address the problem of opioid withdrawal. Opioids are essential for pain-relief in the short term, but their continued use is associated with a host of adverse effects.
- Conditions
- Chronic Pain, Drug Dependence of Morphine Type, Symptom, Withdrawal
- Trial name
- NCT04939623
- Testing
- Probenecid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Opioid Use, Opioid Use Disorder
Translation and Validation of the COMM and ASI-SR
The goal of this observational study is to translate the COMM (Current opinion misuse measure) form and validate it using the ASI-SR (Addiction severity score-self report)in a Swedish population of pain patients treated with…
- Conditions
- Opioid Use, Opioid Use Disorder, Alcohol Use Disorder, Pain, Chronic
- Trial name
- COMMISS (NCT06084520)
- Testing
- Current Opioid Misuse Measure (COMM)-SWE, Oral fluid drug test, PETh
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Uppsala University
Chronic Non-specific Low Back Pain
Effect of VR-MBCT in Chronic Nonspecific Low Back Pain
This is a multi-center, prospective, open-label randomized controlled trial evaluating the efficacy and safety of virtual reality-based mindfulness-based cognitive therapy (VR-MBCT) as an adjunct to usual care in adults with…
- Trial name
- VR-MBCT-CNLBP (NCT07589790)
- Testing
- Virtual Reality-Based Mindfulness Cognitive Therapy (VR-MBCT), Waitlist Usual Care Control Group
- Where
- China
- Volunteers
- 214 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Vulvar Pain Symptoms, Vulvodynia (Chronic Vulvar Pain)
To Evaluate if the Medication Gabapentin Lessens Vulvar Pain
The purpose of this research study is to evaluate if the medication gabapentin lessens the vulvar pain some women experience.
- Trial name
- NCT00390013
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Colleen Stockdale
Lumbar Disc Herniation, Chronic Low Back Pain
PTED Versus Radiofrequency Ablation for Lumbar Disc Herniation
Lumbar disc herniation (LDH) is a common and frequently-occurring disease giving rise to low back pain and (or) leg pain. There are about 1.5 million people with LDH-related pain, accounting for 10% of outpatients each year in…
- Trial name
- PTED (NCT03634046)
- Testing
- Percutaneous transforaminal endoscopic discectomy, Radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Fibromyalgia
Efficacy Trial of Oral Tetrahydrocannabinol in Patients With Fibromyalgia
The objective of the study is to evaluate the effectiveness of oral tetrahydrocannabinol in patients suffering from Fibromyalgia
- Trial name
- NCT01149018
- Testing
- Tetrahydrocannabinol
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Hadassah Medical Organization
Chronic Pain
The Effectiveness of Information and Relaxation on Pre-procedural Block Anxiety and Procedural Discomfort During Medial Branch Block
Patient presenting to chronic pain clinics frequently undergo diagnostic and therapeutic spinal injections as part of their treatment.
- Trial name
- TIRAP (NCT00901082)
- Testing
- Relaxation and information session
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Louise Lamb
Lumbosacral Radiculopathy, Sciatica
A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE
The Move-MORE study is designed to evaluate a multicomponent mindfulness and movement program for patients with lumbosacral radiculopathy.
- Conditions
- Lumbosacral Radiculopathy, Sciatica, Chronic Low Back Pain With a Neuropathic Component, Radiculopathy Lumbar
- Trial name
- Move-MORE (NCT07125027)
- Testing
- Move-MORE
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National University of Natural Medicine
Chronic Pain, Major Depressive Disorder
The Internet Therapy for Depression Trial
The objective of this trial is to collect data on the feasibility, acceptability, and preliminary effectiveness of internet delivered Cognitive Beaviour Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) interventions…
- Trial name
- INTEREST (NCT04009135)
- Testing
- internet delivered cognitive behavioural therapy (iCBT), online delivered acceptance and commitment therapy (iACT), Attention Control (AC)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Memorial University of Newfoundland
Pulsed Radiofrequency, Shoulder Individual Nerves Brachial Plexus
Pulsed Radiofrequency of Shoulder Individual Nerves Versus Brachial Plexus in Management of Chronic Post Mastectomy Shoulder Pain
this study aims to assess the role of pulsed radiofrequency of the brachial plexus or pulsed radiofrequency of shoulder individual nerves in the management of post-mastectomy shoulder pain.
- Conditions
- Pulsed Radiofrequency, Shoulder Individual Nerves Brachial Plexus, Chronic, Post Mastectomy
- Trial name
- NCT07002944
- Testing
- Brachial plexus pulsed radiofrequency, Sholder individual nerves pulsed radiofrequency, Control
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Cervical Pain, Posterior, Swallowing Difficulties
Tongue Pressure in Middle-Aged and Elderly Individuals With Chronic Cervical Pain
The goal of the cross-sectional study is to explore the impact of neck pain on tongue pressure in the middle-aged and elderly population and analyze the effects of different cranio-cervical positioning on tongue pressure…
- Conditions
- Cervical Pain, Posterior, Swallowing Difficulties, Swallowing Disorders
- Trial name
- NCT07021586
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Fibromyalgia
Fecal Microbiome Transplantation From Healthy Donors to Individuals With Fibromyalgia
This study aims to investigate if a fecal microbiome transplantation (FMT) from healthy donors can reduce symptoms of fibromyalgia, a condition causing chronic pain that is difficult to treat and diagnose.
- Trial name
- FM-FMT-RCT (NCT06424041)
- Testing
- Fecal Microbiome Transplantation
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Chronic Venous Insufficiency
Long-term Effects of Inspiratory Muscle Training in Chronic Venous Insufficiency
The long-term effectiveness of inspiratory muscle training, which is known in the literature to help venous return by increasing the pump effect of the diaphragm muscle, remains unclear in individuals with chronic venous…
- Trial name
- NCT05982405
- Testing
- Training group: Inspiratory muscle training, Control group: Thoracic expansion exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Democracy University