Clinical trials: Pain, Chronic Post-Surgical
Chronic Rhinosinusitis (Diagnosis)
Post-operative Pain Control With Acetaminophen and Ibuprofen After Functional Endoscopic Sinus Surgery
The safest and most effective post-operative pain control regimen after functional endoscopic sinus surgery (FESS) has been the subject of persistent research.
- Trial name
- NCT05287217
- Testing
- Comparison of medication administration for pain control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Failed Back Surgery Syndrome, Post-Laminectomy Syndrome
SENSE (Subcutaneous and Epidural Neuromodulation System Evaluation) Study
The purpose of the study is to demonstrate safety and efficacy of spinal cord stimulation with peripheral nerve field stimulation for the treatment of chronic low back and leg pain.
- Conditions
- Failed Back Surgery Syndrome, Post-Laminectomy Syndrome, Low Back Pain
- Trial name
- SENSE (NCT01990287)
- Testing
- SCS and PNfS, SCS Alone
- Where
- 28 sites in United States
- Volunteers
- 38 people
- Sponsor
- Abbott Medical Devices
Failed Back Surgery Syndrome
A Post Market Study on Dorsal Root Ganglion (DRG) Stimulation in Failed Back Surgery Syndrome (FBSS)
18-SMI-2013 is a post market, observational, questionnaire based study to assess the effectiveness of the commercially available Axium neurostimulator in the management of chronic pain following lumbar discectomy (Failed Back…
- Trial name
- SYMPATHY (NCT02335216)
- Testing
- Implantation with the commercially available Axium neurostimulator
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Abbott Medical Devices
Knee Osteoarthritis, Chronic Post Operative Pain
Opioid Reduction in Orthopaedic Surgery (OREOS) - Knees
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Trial name
- OREOS (NCT04968132)
- Testing
- Multicomponent opioid reduction and pain management pathway, Standard care
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Kim Madden
Chronic Pain
Predisposition to Persistent Pain After Orthopaedic Surgery: Genetic Aspects
The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery.
- Trial name
- NCT01989351
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- ASST Gaetano Pini-CTO
Postoperative Pain
The Perioperative Pain Self-Management Program Trial
This study will trial the impact of teaching surgical patients a pain self-management approach to compliment medical post-surgical pain management.
- Trial name
- PePS (NCT04979429)
- Testing
- Perioperative Pain Self-management (PePS)
- Where
- 2 sites in United States
- Volunteers
- 401 people
- Sponsor
- VA Office of Research and Development
Chronic Post-surgical Pain
Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults
The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify…
- Trial name
- NCT05304286
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Hyperalgesia, Pain, Postoperative
Effects of Nefopam on Hyperalgesia After Cardiac Surgery
Postoperative pain after major surgery is consecutive not only to the nociceptive inputs coming from the surgical lesion, but also to peripheral and central neuronal sensitization.
- Conditions
- Hyperalgesia, Pain, Postoperative, Pain, Chronic Disease
- Trial name
- NefalCard (NCT00413257)
- Testing
- Nefopam, néfopam
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux
Acute Pain, Chronic Pain
Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery
The aim of the study is to evaluate efficacy and safety of long term (14 days) wound infusion with levobupivacaine in patients with breast cancer undergoing mastectomy with immediate breast reconstruction: this is a double blind…
- Conditions
- Acute Pain, Chronic Pain, Wound Infusion, Mastectomy
- Trial name
- NCT02035904
- Testing
- Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia), saline, Levobupivacaine continuous infusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Chronic Rhinosinusitis, Enhanced Recovery After Surgery
Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery
Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of Functional endoscopic sinus surgery (FESS) is one of the effective ways to treat chronic sinusitis, which has the advantages of…
- Trial name
- NCT06920576
- Testing
- Esketamine, Magnesium sulfate, Saline
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Second People's Hospital of Huai'an
Serratus Plane Block, Chronic Pain
Serratus Plane Block in Preventing Postoperative Pain of Mastectomy
A prospective, double-blinded randomized controlled, 1-year follow-up study was designed to compare the analgesic effect of serratus plane block (SPB) after breast cancer surgery.
- Conditions
- Serratus Plane Block, Chronic Pain, Breast Cancer
- Trial name
- NCT03615430
- Testing
- serratus plane block with local anesthetic, serratus plane block with saline
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Feng Xia
Cholecystitis, Cholecystitis, Acute
EOIB for Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy, while less painful compared to conventional methods, is still a surgery that can cause significant pain for patients.
- Conditions
- Cholecystitis, Cholecystitis, Acute, Cholecystitis, Chronic, Cholecystitis; Gallstone
- Trial name
- NCT06656299
- Testing
- ultrasound guided external oblique intercostal plane block, Bupivacaine injection, paracetamol, tramadol, and ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Knee Osteoarthritis, Arthropathy of Knee Joint
Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia
Previous retrospective database studies suggest that total knee arthroplasty (TKA) surgery under spinal anesthesia has less complications than when performed under general anesthesia.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee Joint, Knee Pain Chronic, Rheumatoid Arthritis
- Trial name
- NCT03364088
- Testing
- Spinal anesthesia with tourniquet, Spinal anesthesia without tourniquet, General anesthesia with tourniquet
- Where
- Finland
- Volunteers
- 402 people
- Sponsor
- Riku Antero Palanne
Pain, Postoperative, Hernia, Inguinal
Surgical Pain After Inguinal Hernia Repair (SPAIHR)
The purpose of this study is to test whether pregabalin added to the standard of care with dosing starting preoperatively and continuing for 1 week post surgery will decrease the intensity of acute post-operative pain following…
- Trial name
- NCT00551135
- Testing
- Pregabalin
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 425 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Major Abdominal Surgery, Chronic Pain
Persistent Opioid Consumption After Major Abdominal Surgery and Its Determinants
The opioid crisis is a growing problem around the world, with prescription opioids being a major contributor to this crisis. They can be prescribed in different chronic and acute settings, such as surgery.
- Conditions
- Major Abdominal Surgery, Chronic Pain, Opioid Use
- Trial name
- POCAS (NCT05197465)
- Testing
- Questionnaires
- Where
- 2 sites in Canada
- Volunteers
- 700 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pain, Postoperative, Chronic Postoperative Pain
QLB After Nephrectomy
Oxycodone consumption and postoperative pain intensity in patients undergoing nephrectomy procedures. Of all study participants, 50% will obtain quadratus lumborum block (QLB).
- Trial name
- NCT03529201
- Testing
- QLB, PCA, GA
- Where
- 2 sites in Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Lublin
Post Surgical Pain, Post Operative Pain
Chronic Postsurgical Pain: Multivariate Prediction Model
The goal of this observational study is to identify the risk factors of Chronic Postoperative pain (or Chronic Post Surgery Pain - CPSP) three months after surgery and, subsequently.
- Conditions
- Post Surgical Pain, Post Operative Pain, Postoperative Pain, Chronic
- Trial name
- CPoP (NCT06417528)
- Testing
- Chronic Post Surgery Pain (CPSP)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
Postoperative Pain, Pain Management
Comparison of Two Postoperative Care Strategies After Breast Surgery
The goal of this clinical trial is to compare two postoperative analgesia strategies in adult women undergoing breast surgery and to evaluate their effects on postoperative pain and quality of recovery after hospital discharge.
- Conditions
- Postoperative Pain, Pain Management, Breast Surgery, Chronic Postoperative Pain
- Trial name
- NCT07880223
- Testing
- Patient Education, Paracetamol, Dexketoprofen
- Where
- Greece
- Volunteers
- 108 people
- Sponsor
- Moumtzidou Maria Aikaterini
Vitamin C, Post-mastectomy Pain Syndrome
Vitamin C on Acute and Chronic Post Mastectomy Pain
This prospective randomized double-blinded controlled study will be conducted to evaluate the effect of perioperative vitamin C on acute and chronic post mastectomy pain after breast cancer surgery
- Trial name
- NCT05770596
- Testing
- vitamin C group
- Where
- Egypt
- Volunteers
- 204 people
- Sponsor
- Tanta University