Clinical trials: Pain, Chronic Post-Surgical
Pain, Postoperative, Breast Cancer
Postoperative Analgesia Impact of Narcotic Free Anesthesia
The first hypothesis of the study is that substituting fentanyl by esmolol and metoprolol during general anesthesia for patients undergoing mastectomy will result in less pain and less narcotic consumption in the recovery room.
- Conditions
- Pain, Postoperative, Breast Cancer, Postoperative Nausea and Vomiting
- Trial name
- PAINFree (NCT01544959)
- Testing
- fentanyl, beta-blocker (esmolol, metropolol)
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Université de Sherbrooke
Chronic Postoperative Pain
Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy: Analysis of Risk Factors and Association With Genetic Polymorphisms
The treatment of postoperative pain continues to be inadequate in the investigators practice setting. Inadequate pain treatment not only contributes to postoperative complications in the short term but can also be a factor that…
- Trial name
- NCT01510496
- Testing
- Inguinal herniorraphy., Hysterectomy., Thoracotomy .
- Where
- 26 sites in Spain
- Volunteers
- 3,979 people
- Sponsor
- Fundacion IMIM
Chronic Pain
Trigger-point Blockade in Persistent Pain After Laparoscopical Groin Hernia Repair
Groin hernia repair is a common procedure performed in approximately 2,000 patients per one million inhabitants. Severe chronic pain following groin hernia repair is seen in 2-5% of the patients indicating that a large number of…
- Trial name
- Trigger-lap (NCT02065804)
- Testing
- Bupivacaine
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University of Copenhagen
Breast Cancer Female, Postoperative Pain
Study of Lipid Mediators in Chronic Postoperative Pain - LICP
This interventional prospective study aims firstly to investigate variations in lipid levels in blood samples and their potential relationship with the duration and/or intensity of post-operative pain.
- Trial name
- LICP (NCT06907810)
- Testing
- Blood sample + questionnaire
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Université Catholique de Louvain
Breast Cancer, Chronic Pain
Effect of Perioperative CBT on Chronic Persistent Postsurgical Pain Among Breast Cancer Patients
Chronic persistent post-surgical pain (CPSP) is defined as pain at or near the site of surgery persisting for 3 months or more after the date of surgery.
- Conditions
- Breast Cancer, Chronic Pain, Chronic Postsurgical Pain, Quality of Life
- Trial name
- NCT04924010
- Testing
- Cognitive Behavioural Therapy (CBT), Education and Mindfulness
- Where
- Ireland
- Volunteers
- 48 people
- Sponsor
- Mater Misericordiae University Hospital
Chronic Opioid Use
VA Transitional Pain Service Study
The VA Community Care Program has provided an important resource to improve access to surgical care for Veterans unable to have treatment at VA Medical Centers (VAMC).
- Trial name
- VATPS (NCT06223503)
- Testing
- Transitional Pain Service
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- VA Office of Research and Development
Hyperalgesia, Pain
Local Anesthetic Infusion and Sternotomy
Cardiac surgery often induces acute postoperative pain and moreover chronic dysesthesia frequently occur long-term after sternotomy.
- Trial name
- CARDIODOLAL (NCT00802048)
- Testing
- Local anesthetic (Ropivacaine), Saline
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Surgical Procedures, Operative, Pain
Evaluation of Pain Trajectories After Surgery and Their Potential Relationship With Chronicity at 3 Months
The effective management of acute postoperative pain remains a daily challenge despite the organizational efforts made and the techniques put in place.
- Conditions
- Surgical Procedures, Operative, Pain, Chronic Pain
- Trial name
- ETADOL (NCT05326737)
- Testing
- In hospital pain evaluation, In hospital questionnaires, Telephone contact at 3 months
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Postoperative Pain, Postoperative Pain, Acute
Incidence of Chronic Pain After Video-Assisted Thoracic Surgery
Video-assisted thoracic surgery (VATS) is frequently performed in thoracic surgery. It is widely accepted that VATS causes acute pain.
- Conditions
- Postoperative Pain, Postoperative Pain, Acute, Postoperative Pain, Chronic, VATS
- Trial name
- NCT05187390
- Testing
- VATS application
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Primary Inguinal Hernia
The Effect of Preemptive Regional Anesthesia (TAP-block) on Acute and Chronic Pain After Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP)
The study is devoted to the impact of preemptive regional Transversus abdominal plane block on the postoperative acute and chronic pain after elective Transabdominal preperitoneal (TAPP) inguinal hernia repair.
- Trial name
- ERA-TAPP (NCT06406959)
- Testing
- Transversus abdominal plane block (TAP block)
- Where
- Russia
- Volunteers
- 78 people
- Sponsor
- Pirogov Russian National Research Medical University
Chronic Postoperative Pain
Prevalence, Impact and Predictors of Chronic Postoperative Pain
Chronic postoperative pain (CPP) remains a disturbing and obscure clinical problem, which could last for more than 3 months after surgery.
- Trial name
- NCT03363672
- Volunteers
- 500 people
- Sponsor
- Peking Union Medical College Hospital
Urethral Stricture
Intraoperative Lidocaine or Dexmedetomidine for Postoperative Pain Modulation After Urethral Reconstruction.
The development of chronic postoperative pain (CPP) following surgery is influenced by several factors, among which the intensity of acute postoperative pain in the immediate perioperative period and mechanisms related to nerve…
- Trial name
- NCT07676942
- Testing
- Perioperative lidocaine infusion, Perioperative dexmedetomidine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Postsurgical Pain Management, Postsurgical Pain, Chronic
An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service
The goal of this clinical trial is to learn whether a pain-management program called a Transitional Pain Service can help prevent long-term pain and reduce opioid needs after surgery in adult surgical patients who may be at…
- Conditions
- Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery
- Trial name
- TPS-Select (NCT07296770)
- Testing
- TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures
- Where
- United States
- Volunteers
- 474 people
- Sponsor
- University of California, San Francisco
General Anesthesia, Chronic Pain, Postoperative
Risk Factors for Chronic Postoperative Pain After Elective Nephrectomy
Chronic postoperative pain (CPP) is typically defined as pain persisting for 3 months or more after surgery[1]. CPP is a common and increasingly prevalent morbidity, leading to long-term psychological issues, reduced quality of…
- Conditions
- General Anesthesia, Chronic Pain, Postoperative, Acute Pain, Postoperative, Surgery
- Trial name
- NCT06673979
- Testing
- Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Postoperative Pain
A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain
Surgical pain is a common complication after surgery, affecting patient recovery and treatment quality. >20% of patients suffer from chronic postoperative pain. China has >70 million surgeries yearly.
- Trial name
- NCT06281431
- Testing
- Echogenic nerve block needle, Non-echogenic nerve block needle
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Postoperative Pain, Video-assisted Thoracoscopic Surgery
ESP Block, CNP and QoL After VATS
The Erector Spinae Plane Block (ESPB) is an adequate alternative for pain management after video-assisted thoracoscopy surgery (VATS).
- Trial name
- NCT04737902
- Testing
- Erector spinae plane block
- Where
- Colombia
- Volunteers
- 42 people
- Sponsor
- Hospital Universitario San Ignacio
Acute Pain, Chronic Pain
The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery
The project will apply the methods of clinical observation experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and…
- Conditions
- Acute Pain, Chronic Pain, Thoracic Surgery, Electroencephalography
- Trial name
- NCT03761576
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yi Feng, MD
Breast Cancer
Investigation of the Efficiency of Pain Neuroscience Education in Patients With Chronic Pain After Breast Cancer Surgery
Breast cancer is the most common type of cancer among women worldwide. Various side effects are seen after the treatments (surgery, chemotherapy, radiotherapy, etc.).
- Trial name
- NCT06052085
- Testing
- Pain Neuroscience Education, Biomedical Pain Education, Standard Physiotherapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Esketamine, Pregabaline
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.
Chronic postsurgical pain has become one of the most common complications of surgery. The quality of life will be impacted once the postsurgical patients are combined with persistent pain.
- Conditions
- Esketamine, Pregabaline, Chronic Post Operative Pain
- Trial name
- NCT06117917
- Testing
- S-ketamine and pregabalin
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Chronic Pain, Pain Measurement
Relationship of Intra-Epidermal Nerve Fibre Density (IENFD) and Structure to Chronic Post-Mastectomy Pain Syndrome (PMPS)
This is a retrospective, observational study which will utilise the Edinburgh Cancer Research Centre's Tissue Bank to provide samples for IENFD testing in those who have undergone mastectomy surgery for breast cancer.
- Conditions
- Chronic Pain, Pain Measurement, Mastectomy, Postoperative Pain
- Trial name
- NCT02919891
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Royal Infirmary of Edinburgh