Clinical trials: Pain, Experimental
Pain, Dentin Sensitivity
Effect of an Experimental Gel Containing Copaiba Oil-resin in the Control of Dentin Hypersensitivity
This randomized, single-blind, placebo-controlled clinical trial aims to clinically evaluate the effect of an experimental gel containing copaiba oleo-resin in the control of dentin hypersensitivity (DH) in non-carious cervical…
- Conditions
- Pain, Dentin Sensitivity, Dentin Desensitizing Agents
- Trial name
- NCT06872749
- Testing
- KF2 (Potassium nitrate gel), experimental Copaiba gel
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Headache
Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients
The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.
- Trial name
- NCT00564408
- Testing
- Carbachol
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Headache Center
Experimental Pain in Healthy Human Subjects
How do Alpha Oscillations Shape the Perception of Pain? - An EEG-based Neurofeedback Study
Pain is closely linked to alpha oscillations (8 -13 Hz) which are thought to represent a supra-modal, top-down mediated gating mechanism that shapes sensory processing.
- Trial name
- NCT05570695
- Testing
- attention right training, ARTNF, attention left training, ALTNF
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Chronic Pain, Low Back Pain
A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain
The primary objective of the study is to determine the analgesic efficacy and safety of ALO-02 extended-release capsules, when compared to placebo, in subjects with moderate to severe chronic low back pain.
- Conditions
- Chronic Pain, Low Back Pain, Analgesia
- Trial name
- NCT01571362
- Testing
- ALO-02
- Where
- 52 sites in United States
- Volunteers
- 410 people
- Sponsor
- Pfizer
Pain, Chronic Widespread Pain
Pain Reprocessing Therapy for Chronic Widespread Pain: a SCED Study
Chronic Widespread Pain (CWP) is classified as a Chronic Primary Pain syndrome in the ICD-11 and is considered a major type of nociplastic pain with an estimated prevalence of up to 8-10% in the general population.
- Conditions
- Pain, Chronic Widespread Pain, Chronic Pain, Fibromyalgia
- Trial name
- FOKUS (NCT07050758)
- Testing
- Pain Reprocessing Therapy
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Nutrition Poor, Overweight and Obesity
Nutrition Care in Patients Living With Chronic Pain
The investigators' purpose is to develop and test the feasibility, usability, and satisfaction of the Diet4painrelief app as a platform for implementing nutrition care in a specialist pain rehabilitation clinic.
- Conditions
- Nutrition Poor, Overweight and Obesity, Mobile Phone Use, Pain, Chronic
- Trial name
- NCT06277232
- Testing
- Nutrition care, Dialogue and education (part of Interdisciplinary Pain Rehabilitation Program), activity training (part of Interdisciplinary Pain Rehabilitation Program)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Linkoeping University
Pain
Evaluation of Pain Measurement Device
This longitudinal observational study will attempt to objectively measure pain with an experimental, non-invasive device. Patients and volunteers will receive a baseline screening with psychophysical tests and questionnaires.
- Trial name
- NCT02036567
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Drugs, Investigational
Evaluate Analgesic Efficacy of Fast Release Aspirin
The objective of the study is to evaluate the analgesic efficacy of a single, oral dose of fast release aspirin tablets, 1000 mg (2 x 500 mg) compared to regular aspirin tablets, 1000 mg (2 x 500 mg) and placebo in subjects with…
- Trial name
- TAROT (NCT01117636)
- Testing
- Acetylsalicylic acid (Fast release Aspirin, BAY1019036), Acetylsalicylic Acid (Aspirin, BAYE4465)
- Where
- 2 sites in United States
- Volunteers
- 514 people
- Sponsor
- Bayer
Headache
Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of carbachol.
- Trial name
- NCT00357864
- Testing
- carbachol
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Pain
An Exploratory Study to Assess the Effects of JNJ-39439335 on the Relief of Pain Using a Thermal-Grill Experimental Model
This exploratory study will use a thermal-grill experimental model to assess the effects of JNJ-39439335 (50 mg, single oral dose) on the relief of pain.
- Trial name
- NCT01006304
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis, Cancer Pain
Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies
A4091065 is a multicenter, prospective, cohort study with enhance physical an neurodevelopmental surveillance to characterize the outcomes related to the development of infants up to the age of 15 months who were potentially…
- Conditions
- Osteoarthritis, Cancer Pain, Recurrent Low Back Pain
- Trial name
- NCT03031938
- Testing
- Investigational medical product (IMP) administered in parent study
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- Pfizer
Opioid-Related Disorders, Chronic Pain
Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain
Pain is very common in persons with a history of addiction, but few studies have examined the best treatment of pain in this population.
- Trial name
- 1401 (NCT02372591)
- Testing
- Buprenorphine, Hydromorphone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Delirium Confusional State
Exploring the Effectiveness of Intelligent Audiovisual Interventions in Delirium, Agitation, and Pain Among Middle Aged and Elderly Patients in Emergency Intensive Care Units: A Quasi-Experimental Study
The goal of this nonrandomized, quasi-experimental clinical trial is to evaluate whether an intelligent audiovisual intervention can prevent delirium and reduce delirium severity, agitation, and pain among adults aged 55 years or…
- Trial name
- NCT07776002
- Testing
- Intelligent Audiovisual Intervention
- Volunteers
- 128 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
DeQuervain's Tenosynovitis
Local Corticosteroid Injection Versus Open Surgical Release in De Quervain Tenosynovitis: A Single-Center Study
This quasi-experimental study compared pain outcomes following local corticosteroid injection (CSI) versus open surgical release in 100 patients with clinically confirmed De Quervain tenosynovitis unresponsive to conservative…
- Trial name
- NCT07683429
- Testing
- Triamcinolone acetonide with lidocaine, Open surgical release of first dorsal extensor compartment
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Rawalpindi Teaching Hospital, District Headquarter Hospital, Rawalpindi
Postoperative Pain, Anxiety
Effects of Foot Reflexology on Postoperative Pain, Anxiety, Nausea, and Vomiting Among Patients After Laparoscopic Cholecystectomy
This study aims to evaluate the effect of foot reflexology on pain, anxiety, nausea, and vomiting among patients after laparoscopic cholecystectomy.
- Conditions
- Postoperative Pain, Anxiety, Nausea, Vomiting
- Trial name
- NCT07770295
- Testing
- Foot reflexology
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Ain Shams University
Pain Perception
The Impact of an Immersive Digital Therapeutic Tool on Pain Perception
The goal of this experimental study is to examine the impact of a virtual reality paradigm on heat pain perception in healthy volunteers.
- Trial name
- NCT06130267
- Testing
- Endocare
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Stéphane Potvin
Experimental Pain in Healthy Human Participants
Sensory Evidence and Expectations in Pain Processing
Pain is a highly complex and subjective phenomenon which is not only rooted in sensory information but also shaped by cognitive processes such as expectation.
- Trial name
- NCT04296968
- Testing
- Painful stimulation using a laser device (DEKA Stimul 1340, Calenzano, Italy), Visual cueing
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Mechanical Neck Pain
Effect of Dynamic Cupping Versus Myofascial Release Therapy in Patients With Mechanical Neck Pain
A Quasi-experimental study will investigate the effect of dry cupping massage versus myofascial release on patients with mechanical neck pain.
- Trial name
- NCT06031571
- Testing
- dry cupping massage, Myofacial release
- Where
- 2 sites in Egypt
- Volunteers
- 38 people
- Sponsor
- South Valley University
Cervical Radiculopathy
Effect of Manual Therapy on Sensory Features in Patients With Cervical Radiculopathy
Background \& Purpose: Cervical radiculopathy is a neurological disorder, which commonly results because of nerve compression. There are different types of physical therapy interventions that are used for cervical radiculopathy.
- Trial name
- NCT03328351
- Testing
- manual therapy, Superficial soft tissue massage
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 28 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Musculoskeletal Pain, Musculoskeletal Injury
A New Experimental Model of Transient and Short-lasting Muscle Pain in Humans Based on Diathermy
This study evaluates the use of short-wave diathermy (SWD) as an novel experimental model to induce transient and intensity-controlled muscle pain by heating muscle tissue.
- Trial name
- NCT03573219
- Testing
- Short-wave diathermy
- Where
- Argentina
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina