Clinical trials: Pain, Intractable, open to volunteers
Refractory Angina, Coronary Artery Disease
Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.
This is a two-part study, comprised of an initial open-label run-in phase (Part 1) in a subset of 3 subjects to provide first data regarding safety, and feasibility of the percutaneous endovascular catheter-facilitated…
- Trial name
- EXACT2 (NCT07048808)
- Testing
- XC001
- Where
- 14 sites in United States
- Volunteers
- 106 people
- Sponsor
- XyloCor Therapeutics, Inc.
Refractory Migraine, Headache
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)
- Trial name
- LIGHT 2 (NCT07361549)
- Testing
- Lidocaine (drug), Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Daniel A Tonetti, MD
Intrathecal Drug Delivery, Refractory Cancer Pain
Intrathecal Therapy Versus Standard Care for Severe Cancer Pain
Approximately 66% of patients with advanced cancer experience pain, which is often inadequately controlled and associated with a decline in health-related quality of life (HRQoL).
- Conditions
- Intrathecal Drug Delivery, Refractory Cancer Pain, Conventional Medical Management
- Trial name
- CAREGIVER (NCT07691840)
- Testing
- Intrathecal Drug Delivery, Comprehensive Medical Management
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Universitair Ziekenhuis Brussel
Spinal Cord Injury, Neuropathic Pain
Effect of TMS on Neuropathic Pain for Patients With Sci
The aim of this study is to evaluate the efficacy of rTMS targeting the anterior cingulate cortex, another stimulation site that may be effective in the treatment of neuropathic pain, and to compare it with motor cortex…
- Trial name
- NCT07293780
- Testing
- active TMS
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Ankara Etlik City Hospital
Refractory Pain
OP2C : Prialt® Observatory in Clinical Practice
Ziconotide is a strong analgesic marketed since 2005 in Europe and reserved for the intrathecal route. Its efficacy has been proven in particular by 3 randomized clinical studies.
- Trial name
- OP2C (NCT04321408)
- Testing
- Ziconotide Injection
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 300 people
- Sponsor
- Institut Cancerologie de l'Ouest
Chronic Neuropathic Pain
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)
This research is being done to study a possible treatment for refractory pain due to small fiber neuropathy (SFN). ST-503 is intended to deliver a modified copy of the gene which will ideally repress Nav1.7 tissue-related pain…
- Trial name
- NCT06980948
- Testing
- ST-503
- Where
- 11 sites in United States
- Volunteers
- 27 people
- Sponsor
- Sangamo Therapeutics
Chronic Pain
Observational Study of Ketamine Infusions for the Treatment of Chronic Pain
This observational study will collect prospectively specified data on patient characteristics and clinically relevant outcomes in patients who receive a ketamine infusion at Stanford Pain Management Center for the treatment of…
- Trial name
- NCT05477004
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Theresa Lii
Crohns Disease
Treatment of Moderate to Severe Refractory Crohn's Disease
This research study is testing an investigational research product called TRX103 as a possible treatment for individuals suffering from Crohn's Disease (CD).
- Trial name
- NCT06721962
- Testing
- TRX103, Cyclophosphamide
- Where
- 13 sites in United States
- Volunteers
- 39 people
- Sponsor
- Tr1X, Inc.
Chronic Neuropathic Pain
Evaluation of the Efficacy of STNS With FAST and MULTIWAVE in Patients With Refractory Chronic Neuropathic Pain
The goal of the study is to demonstrate Spinal Transforaminal NeuroStimulation effectiveness with FAST and other waveforms / combinations to relief neuropathic peripheral pain in chronic neuropathic pain patients, at low risk and…
- Trial name
- FORASTIM (NCT07154056)
- Testing
- Lead(s) and Implantable Pulse Generator implantation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Poitiers University Hospital
Lower Back Pain
Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain
This clinical study is being conducted to evaluate the safety, tolerability, plasma pharmacokinetics and efficacy of an investigational drug called CNTX-3001.
- Trial name
- NCT07122453
- Testing
- CNTX-3001
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Refractory Cancer Pain, Cancer Pain
Hydromorphone With Electroacupuncture and Ear Acupoint Pressing for Refractory Cancer Pain
This trial aims to address refractory cancer pain (RCP). It will explore the synergistic efficacy and safety of hydromorphone hydrochloride sustained-release tablets (HHST) combined with electroacupuncture (EA) and ear acupoint…
- Trial name
- NCT07489625
- Testing
- Hydromorphone Hydrochloride Extended-Release Tablets, Electroacupuncture, Ear Acupoint Pressing Beans
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qinghai Red Cross Hospital
Shoulder Pain, Tendinopathy
Embolization Treatment of Chronic Refractory Shoulder Tendinopathy
This is a randomized controlled trial in which patients with moderate to severe shoulder pain (Visual Analog Scale (VAS) > 40), in the setting of rotator cuff tendinopathy refractory to conservative treatment, will be enrolled.
- Conditions
- Shoulder Pain, Tendinopathy, Rotator Cuff Tendinitis, Rotator Cuff Tendinosis
- Trial name
- ELECTRC (NCT06095050)
- Testing
- Embolization, Physical Therapy
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Brigham and Women's Hospital
Chronic Refractory Plantar Fasciopathy
Multimodal Conservative Intervention Versus Surgery for Chronic Refractory Plantar Fasciopathy
Chronic refractory plantar fasciopathy is a common musculoskeletal condition that can cause persistent heel pain and functional limitations despite conservative treatment.
- Trial name
- NCT07654660
- Testing
- Multimodal Conservative Intervention, Endoscopic Plantar Fascial Release
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad Europea de Valencia
Refractory Angina Pectoris, Refractory Angina
Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina
REGENERATE-COBRA will examine whether autologous stem cell treatment can improve angina symptoms and quality of life for patients with refractory angina.
- Trial name
- RegenCobra (NCT05711849)
- Testing
- Bone marrow aspiration and a single intracoronary infusion of autologous bone marrow-derived mononuclear cells.
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Barts & The London NHS Trust
Cancer, Palliative Care, Patient Care
Dexmedetomidine for Refractory Pain in Palliative Cancer Patients
The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids).
- Conditions
- Cancer, Palliative Care, Patient Care, Pain Management, Dexmedetomidine Analgesia
- Trial name
- DEX-PAL (NCT07885475)
- Where
- 4 sites in Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Neuropathic Chronic Pain
Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if the topical anesthetic cream works to treat neuropathic chronic pain in older adults who have not found sufficient relief undergoing other pain treatments and/or medications.
- Trial name
- NCT07396129
- Testing
- Lidocaine (23%) + Tetracaine (7%)
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Intractable Pain, Palliative Care
Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain
Background: Cancer-induced bone pain (CIBP) is common in people with cancer. Bone cancer can also lead to anxiety, depression, and reduced mobility and quality of life.
- Trial name
- NCT02522611
- Testing
- Resiniferatoxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Coccyx Disorder
Analgesic Efficacy of Capsaicin 8% Patch (QUTENZA®) in Coccygodygnia
A retrospective study over a period of 6 years to explore analgesic efficacy of 8% Capsaicin patch (QUTENZA®) in coccygodynic patients, as well as neuropathic predictive factors of therapeutic response.
- Trial name
- CAPSACOXp (NCT05983263)
- Testing
- Capsaicin
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Pain, Intractable
Medullary Stimulation for the Treatment of Refractory Neck Pain (S2M)
Number of centres planned : 1 (CHU Nantes) Design : Randomized, Prospective Planning of the study : Total duration: 34 months Recruitment period: 24 months.
- Trial name
- S2M (NCT05398003)
- Testing
- Implantation of the WAVEWRITER ALPHA ™ device
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Nantes University Hospital
Chronic Pain, Intractable Pain
Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy
The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR).
- Trial name
- PERSIST (NCT07507422)
- Testing
- Commercially available Inceptiv™ neurostimulation systems
- Where
- 6 sites in United States, France
- Volunteers
- 970 people
- Sponsor
- Medtronic