Clinical trials: Pain, Medication
Postoperative Pain, Anesthesia, Regional
Mid-Transverse Process to Pleural (MTP) Block and Erector Spinal Plan (ESP) Block in Spinal Surgery
Ethics committee approval was taken on October 22, 2019, numbered 19/342. 120 adult patients who will undergo spine stabilization surgery between October 2019 and January 2020 in "Gülhane Training and Research Hospital" were…
- Conditions
- Postoperative Pain, Anesthesia, Regional, Spinal Stenosis
- Trial name
- NCT04193488
- Testing
- MTP block, ESP block, No Block group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
General Anesthesia, Chronic Pain, Postoperative
Risk Factors for Chronic Postoperative Pain After Elective Nephrectomy
Chronic postoperative pain (CPP) is typically defined as pain persisting for 3 months or more after surgery[1]. CPP is a common and increasingly prevalent morbidity, leading to long-term psychological issues, reduced quality of…
- Conditions
- General Anesthesia, Chronic Pain, Postoperative, Acute Pain, Postoperative, Surgery
- Trial name
- NCT06673979
- Testing
- Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people
- Sponsor
- Istanbul University - Cerrahpasa
Acute Pathology of the Locomotor System
Impact of a Personalized Medication Plan on Duration of Treatment With Potent Opioids in Acute Non-cancer Musculoskeletal Pain.
The aim of this study is to evaluate whether patients who benefit from a personalized pharmaceutical plan (PPP) during their hospitalization, allowing them to be informed and sensitized, are treated for a shorter period of time…
- Trial name
- PPPCARE II (NCT05905146)
- Testing
- personalized pharmaceutical plan
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Sacral Erector Spinae, Penile And Caudal Block For Pain Relief After Hypospadius Surgery
Sacral Erector Spinae,Penile and Caudal Block for Pain Relief After Hypospadias Surgery
Caudal anaesthesia is recommended for most surgical procedures of the lower part of the body, mainly below the umbilicus, including inguinal hernia repair, urinary and digestive tract surgery and orthopaedic procedures on the…
- Trial name
- NCT05307653
- Testing
- Penile block, Erector spinea plain block, Caudal block
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Tanta University
Analgesic Efficacy, Dexmedetomidine
Analgesic Efficacy of Adding Dexmedetomidine to Erector Spinae Plane Block Versus Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy
Our scientific work aimed to evaluate the analgesic efficacy of dexmedetomidine as an adjuvant to erector spinae plane block versus subcostal transverse abdominis plane block in patients undergoing laparoscopic cholecystectomy.
- Conditions
- Analgesic Efficacy, Dexmedetomidine, Erector Spinae Plane Block, Subcostal Transverse Abdominis Plane Block
- Trial name
- NCT07075913
- Testing
- Subcostal transverse abdominis plane block, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Lowback and Leg Pain
Analgesic Efficacy of High Frequency Spinal Cord Stimulation
The aim of the study is to compare the efficacy of high frequency (HF SCS) stimulation and sham stimulation (Sham SCS - i.e. no stimulation) and conventional spinal cord stimulation (Conv SCS) on the patient reported global…
- Trial name
- NCT01400282
- Testing
- High frequency spinal cord stimulation
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Ensemble Hospitalier de la Côte
Effect of Drug
Joint Health Study
Natural dietary health supplements that may improve quality of life by relieving joint discomfort have been of increasing interest.
- Trial name
- NCT05438979
- Testing
- Calcium Fructoborate
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Auburn University
Anesthesia, Regional
The Analgesic Efficacy of the Ultrasound-Guided Femoral Articular Branch Block for Ambulatory Hip Arthroscopy
Hip arthroscopy surgery can be associated with significant pain. A regional anesthesia technique, the femoral articular branch block (FAB), has recently been proposed to collectively block terminal femoral and accessory obturator…
- Trial name
- NCT03449680
- Testing
- Femoral Articular Branch Block
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- Women's College Hospital
Parkinson Disease
Comparative Controlled Study of Analgesic, Antiasthenic and Anti-Anxiety Effects of Xenon in Patients With Parkinson's Disease
This study evaluates the hypothesis that the gas mixture with xenon will have a positive effect on the symptoms in patients with Parkinson's Disease.
- Trial name
- NCT04097080
- Testing
- NBTX-001, Standard of Care
- Where
- 2 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Nobilis Therapeutics Inc.
Delirium, Aging
MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care
This will be the first large cohort study to define the epidemiology of and identify modifiable risk factors for long-term CI and functional deficits of ICU survivors.
- Conditions
- Delirium, Aging, Dementia
- Trial name
- NCT00400062
- Where
- 3 sites in United States
- Volunteers
- 800 people
- Sponsor
- VA Office of Research and Development
Analgesia, Anesthesia
Analgesic Depth Evaluation During General Anesthesia With Dexmedetomidine-remifentanil Infusion. A Pilot Study
The aim of this study is to verify the feasibility of an evaluation of the depth of analgesia during an opioid sparing anesthesia (OSA) carried out with continuous infusion of dexmedetomidine in addition to general multimodal…
- Trial name
- NCT05785273
- Testing
- Pupillometer
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Università degli Studi di Brescia
Mammaplasty
The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery
This project intends to more thoroughly investigate the direct influence of Pecs blocks in the administration of Exparel, a non-opioid analgesic, in breast reconstruction surgery.
- Trial name
- NCT05171179
- Testing
- Breast Reconstruction (Mammaplasty), Pecs blocks, Exparel
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Drug Interactions, Anesthesia, Conduction
Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery
Recently a new model for the interaction of sevoflurane propofol and remifentanil was developed. The potency of any combination of the three drugs is defined as probability that a subject tolerates laryngoscopy without movement…
- Trial name
- SPRV (NCT02457442)
- Testing
- Propofol and Remifentanil, Sevoflurane and Remifentanil, SPR 1
- Where
- Switzerland
- Volunteers
- 172 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Postoperative Pain
Quadratus Lumborum Block III Versus Peritubal Local Infiltration
Investigators compare post operative analgesic efficacy of peritubal local infiltration versus Quadratus Lumborum Block III . In patients undergoing Percutaneous Nephrolithotomy operation
- Trial name
- NCT04215705
- Testing
- Quadratus block versus peritubal local infiltration
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Osteoarthritis
Osteoarthritis Bedside Testing Kit
Develop and test a bedside testing kit for evaluating pain and symptoms of osteoarthritis
- Trial name
- NCT00794651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Analgesic Solutions
Pain
Prevention of Post Herpetic Neuralgia by Ultrasound Guided Single Nerve Block in the ED
Herpes zoster causes significant morbidity on over 1 million Americans every year. Although the majority of herpes zoster pain will self-resolve within one week, a significant proportion of patients will develop postherpetic…
- Trial name
- NCT04530162
- Testing
- Ultrasound guided nerve block
- Where
- United States
- Sponsor
- Antonios Likourezos
ER+ Breast Cancer, HER2-negative Breast Cancer
Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast Cancer
This study is a pragmatic international, multicenter, randomized, open label 3- arm trial of standard care vs. two pharmacological interventions: duloxetine or furosemide in patients with stage I-III ER+/HER2- early breast cancer…
- Conditions
- ER+ Breast Cancer, HER2-negative Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT06407401
- Testing
- Duloxetine 60 MG, Furosemide 40 mg, Booklet for healthy behaviors
- Volunteers
- 399 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Nociceptive Pain, Analgesic Adverse Reaction
Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol
This study purpose to compare analgesia efficiency of propofol combine with sevoflurane with propofol only using index of Nociception (NOX)
- Conditions
- Nociceptive Pain, Analgesic Adverse Reaction, Inhalant Use
- Trial name
- NCT03841812
- Testing
- 5mg/kg/h Propofol, Sevoflurane, 2 mg/kg/h Propofol
- Where
- China
- Volunteers
- 146 people
- Sponsor
- China International Neuroscience Institution
Pain
Intravenous Dexamethasone to Increase the Analgesic Duration of Interscalene Block
Interscalene brachial plexus block provides excellent but time limited analgesia. Intravenous dexamethasone increases the analgesic duration of a single-shot interscalene block with ropivacaine for shoulder arthroscopic surgery.
- Trial name
- NCT02412657
- Testing
- Dexamethasone, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Total Knee Anthroplasty, Genicular Nerves Block
Efficacy of Genicular Block on Total Knee Arthroplasty Surgery
This prospective, randomized, double-blind, placebo-controlled trial evaluated the analgesic efficacy of preoperative ultrasound-guided genicular nerve block (GNB) in patients undergoing total knee arthroplasty.
- Trial name
- NCT06942702
- Testing
- Genicular blocks (bupivakain), Paracetamol (acetaminophen)+diclofenac, Patient Control Analgesia (PCA) Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Mersin University
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