Clinical trials: Pain, Medication
Osteoarthritis, Knee
Mesenchymal Stem Cell Therapy for Knee Osteoarthritis
The study is a multicentered, randomized, double-blinded, placebo-controlled study conducted on the unilateral knee of 120 patients.
- Trial name
- NCT05288725
- Testing
- Bone Marrow Derived MSCs, Corticosteroid, Bone Marrow Aspirate
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Next Generation Regenerative Medicine LLC
Acute Pain
Paracetamol UNIFLASH for Buccal Use Phase III Trial in Acute Pain Due to a Tooth Extraction
This study aims to evaluate the analgesic efficacy of single dose of a new paracetamol formulation (paracetamol UNIFLASH) for buccal use in comparison to two different doses of an oral paracetamol form controlled versus placebo.
- Trial name
- NCT04640376
- Testing
- Paracetamol Uniflash 125mg, Panadol 500 MG Oral Tablet X1, Panadol 500 MG Oral Tablet X2
- Where
- 20 sites in France, Italy and 2 more
- Volunteers
- 407 people
- Sponsor
- Unither Pharmaceuticals, France
Post Operative Analgesia
Bilateral External Oblique Intercostal Plane Bock (EOIPB) in Upper Abdominal Surgeries
The current study is designed to investigate the analgesic potentials of two modalities of abdominal blocks where local anesthetics is injected in the fascial planes of the abdominal muscles to anesthetize the nerves supplying…
- Trial name
- NCT07055438
- Testing
- Ultrasound guided Rectus sheath block, ultrasound guided external oblique intercostal plane block
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Paediatric Surgery, Analgesics Prescriptions
Setting up a Website in Paediatric Surgery at the Rouen University Hospital for Parents and Children to Better Understand the Postoperative Prescription of Painkillers.
Although outpatient surgery is increasing in France, particularly in paediatrics, compliance with analgesics prescriptions and pain management on return home remain poorly controlled parameters, although they are essential for…
- Trial name
- DOLIPAR (NCT04564248)
- Testing
- Website access
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Analgesic Effect
Comparison of Caudal Blockade and Dorsal Penile Nerve Block With and Without the Intravenous Administration of Dexamethasone for Analgesia After Paediatric Male Circumcision
Male infant circumcision is a frequently performed, but painful procedure. A variety of methods, both systemic and locoregional, have been developed to overcome postoperative pain after circumcision.
- Trial name
- NCT05598255
- Testing
- Dexamethasone, Caudale Blockade with levobupivacaine, Dorsal penile nerve block with levobupivacaine
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Tumor, Cancer Pain
Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain
The BTP (Breakthrough pain)was defined as "a transient exacerbation of pain that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled…
- Conditions
- Tumor, Cancer Pain, Breakthrough Cancer Pain, Neuropathic Pain
- Trial name
- RER (NCT01946555)
- Testing
- Morphine, Fentanyl, Methadone
- Where
- 11 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Intercostal Nerve Block, Serratus Posterior Superior Intercostal Plane Block
Analgesic Efficiency of SIPSPB vs ICNB in VATS Surgery
This study aims to evaluate the effectiveness of Serratus Posterior Superior Intercostal Plane (SPSIP) block compared to Intercostal Nerve (ICN) block in terms of postoperative pain control, reduction of opioid analgesic…
- Conditions
- Intercostal Nerve Block, Serratus Posterior Superior Intercostal Plane Block, Post-operative Pain Management, VATS
- Trial name
- NCT07577908
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Kocaeli City Hospital
Opioid-Related Disorders, Opiate Addiction
Discontinuation vs Continuation of Long-term Opioid Therapy in Suboptimal and Optimal Responders With Chronic Pain
The purpose of this study is to evaluate the effect on pain intensity (PI) of structured discontinuation of long-term opioid analgesic therapy compared to continuation of opioid therapy in Suboptimal and Optimal Responders to…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02741076
- Testing
- Structured discontinuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER), Continuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER)
- Where
- 61 sites in United States
- Volunteers
- 44 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Pain, Postoperative, Anesthesia, Local
Improving Pain Relief Following Laparoscopic Ventral Hernia Repair
Aim The general aim of this study is to improve post-operative pain and reduce morphine consumption following laparoscopic ventral hernia repair (LVHR).
- Conditions
- Pain, Postoperative, Anesthesia, Local, Hernia, Ventral, Laparoscopy
- Trial name
- NCT02785276
- Testing
- AutoFuser Pain Pump, Ropivacaine, Normal Saline (0.9%)
- Where
- New Zealand
- Sponsor
- University of Auckland, New Zealand
Knee Arthropathy
Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Knee Surgery
Postoperative pain remains undertreated with inadequate analgesic options. Opioids have well-known limitations for both individuals and society; single-injection and continuous peripheral nerve blocks provide intense analgesia…
- Trial name
- NCT07336355
- Testing
- Percutaneous peripheral nerve stimulation
- Where
- United States
- Sponsor
- University of California, San Diego
Osteoarthritis
Efficacy and Safety of Lumiracoxib
This trial assessed the safety and efficacy of a single dose of lumiracoxib 400 mg compared to placebo and to a single dose of celecoxib 200mg.
- Trial name
- NCT00267215
- Testing
- Lumiracoxib
- Where
- Germany
- Volunteers
- 330 people
- Sponsor
- Novartis
More Effective Postoperative Analgesia After Modified Radical Mastectomy With Better Drug Combination, More Prolonged Duration of Postoperative Analgesia After Modified Radical Mastectomy With Better Drug Combination
Comparing Effect of Adding Ketamine Versus Dexmedetomidine to Bupivacaine in Pec 11 Modified Block on Postoperative Pain Control in Patients Undergoing Breast Surgery
in our study we are trying to reach to the preferred adjuvant from either ketamine or dexmedetomidine to be added to bupivacaine local anesthetic during pec 11 modified block as regard its efficacy and duration of postoperative…
- Trial name
- NCT04380168
- Testing
- Modified pec11 trunk block
- Where
- Egypt
- Volunteers
- 5 people
- Sponsor
- Ain Shams University
Vitrectomy
Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy
Traditional opioid analgesia is a method to treat moderate to severe pain. However, the use of opioids is not without risks. When treating acute pain, patients may have hypotension, respiratory depression, hypoxia, nausea and…
- Trial name
- NCT07097038
- Testing
- Oliceridine, Oxycodone
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Endometrial Biopsy, Abnormal Uterine Bleeding
Effectiveness of Paracervical Block Versus Lidocaine Spray During Endometrial Biopsy
The purpose of this study to determine effectiveness of paracervical block, lidocaine spray and only oral analgesic drugs for pain relief during endometrial biopsy.
- Trial name
- NCT01908738
- Testing
- paracervical block with 1%lidocaine, 10%lidocaine spray
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Pain
Impact of Naloxone on the Analgesic Effect of Paracetamol in Healthy Volunteers
The aim of this study is to check if Naloxone induce an inhibiting effect on the analgesic effect of paracetamol in healthy volunteer, using evoked potentials.
- Trial name
- NCT00750048
- Testing
- Naloxone and paracetamol
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Pain, Postoperative
Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
A multicenter study to evaluate the analgesic efficacy of XP21L in subjects with pain following bunionectomy surgery.
- Trial name
- NCT00366444
- Testing
- diclofenac potassium (XP21L)
- Where
- 6 sites in United States
- Volunteers
- 201 people
- Sponsor
- Xanodyne Pharmaceuticals
Anesthesia, General
The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics
The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using SPI and EEG analysis.
- Trial name
- NCT02698514
- Testing
- Sevoflurane, Desflurane
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Kangbuk Samsung Hospital
Constipation, Bowel Dysfunction
Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication
A multicenter study to evaluate the effectiveness and safety of multiple dosage regimens of an investigational drug for the treatment of constipation due to prescription pain medication in subjects with cancer pain.
- Trial name
- NCT00101998
- Testing
- alvimopan
- Where
- 162 sites in United States, Argentina and 24 more
- Volunteers
- 233 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Lumbar Disc Disease, Spinal Fusion
Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery
The purpose of this study is to determine if treatment with low-dose oral propranolol in the days before and after surgery decrease postoperative pain and improve pain scores.
- Conditions
- Lumbar Disc Disease, Spinal Fusion, Degenerative Disc Disease
- Trial name
- NCT04421209
- Testing
- Propranolol Hcl 40mg Tab
- Where
- United States
- Sponsor
- Duke University
Low Back Pain, Recurrent, Healthy
Effects of Sleep Disruption on Drug Response
The central scientific premise of the proposed study is that sleep disruption (SD) will influence individuals' subjective response to blinded medication administration.
- Trial name
- NCT03680287
- Testing
- Within-Subject test of blinded study medication
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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