Clinical trials: Pain, Musculoskeletal
Pain, Chronic Disease
Modulation of Central Hypersensitivity in Chronic Musculoskeletal Pain by Intravenous Tropisetron
Chronic pain is associated with hypersensitivity of the central nervous system. The drug under investigation (tropisetron) has been shown in animal studies to attenuate central hypersensitivity.
- Trial name
- NCT00889499
- Testing
- Tropisetron 2 mg, Tropisetron 5mg
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Frozen Shoulder
Adding Vertical Correction to Scapular Recognition on Patients With Frozen Shoulder
OBJECTIVE: To study the effect of adding a continual vertical downward correction to dynamic scapular recognition exercise on scapular dyskinesis and shoulder pain and disability in patients with frozen shoulder.
- Trial name
- NCT04369144
- Testing
- Dynamic Scapular Recognition exercise
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Surgery, Shoulder Impingement
Pupillary Pain Index to Evaluate Interscalene Block and Postoperative Pain in Patients Underwent Shoulder Surgery
When an individual encounters nociceptive pain stimuli, the pupil dilates in a unique manner known as Pupil reflex dilation (PRD).The degree of pupillary reflex dilatation can be further quantified into an objective parameter…
- Trial name
- NCT05590767
- Testing
- Patients scheduled to undergo shoulder rotators repair surgery
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Joint Pain, Gout Flares
A Study to Evaluate Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of LEO 158968
The main objective of the study is to evaluate the effect on pain of a single, subcutaneous (SC) dose of LEO 158968 in participants with gout flares.
- Conditions
- Joint Pain, Gout Flares, Joint Inflammation
- Trial name
- NCT06444867
- Testing
- LEO 158968
- Where
- 3 sites in France, Netherlands and 1 more
- Volunteers
- 6 people
- Sponsor
- LEO Pharma
Plantar Fascitis, Heel Pain Syndrome
Effects of the Diacutaneous Fibrolysis Approach in Patients With Plantar Fasciitis.
Diacutaneous Fibrolysis (FD) is a physiotherapy technique based on Cyricax's transverse massage. Kurt Ekman, its creator, observed that Cyriax's deep transverse massage was intended to achieve a mechanical effect on the tissues…
- Trial name
- NCT05075434
- Testing
- Conventional Treatment, Diacutaneous fibrolysis
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universitat Internacional de Catalunya
Opioid-Related Disorders, Chronic Pain
Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain
Pain is very common in persons with a history of addiction, but few studies have examined the best treatment of pain in this population.
- Trial name
- 1401 (NCT02372591)
- Testing
- Buprenorphine, Hydromorphone
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Knee Osteoarthritis, Sleep Disturbance
Neuropathic Pain and it's Relation to Sleep Quality in Knee Osteoarthritis
The primary aim is to investigate the frequency and severity of neuropathic pain and its association with night pain in patients with knee osteoarthritis. For this purpose a progressive longitudinal study design was planned.
- Conditions
- Knee Osteoarthritis, Sleep Disturbance, Neuropathic Pain
- Trial name
- NCT06430918
- Testing
- physical examination, questionnaires and inventories
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bozyaka Training and Research Hospital
Musculoskeletal Pain
Investigation of Popular Recovery Techniques for Ultramarathon Recovery
The study is a randomized clinical trial examining the effectiveness of massage and intermittent pneumatic compression on recovery from a 161-km ultramarathon.
- Trial name
- NCT02530190
- Testing
- intermittent pneumatic compression, massage
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Western States Endurance Run Research Foundation
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Metatarsalgia
Maximal Plantar Pressure and Comfort Evaluation of Orthopedic Stilettos
22 women Testing "orthopedic" stilettos compared to standard stilettos and a comfy trainer. Testing involves pedobar pressures and a validated comfort questionnaire.
- Trial name
- NCT02667990
- Testing
- orthopaedic stilettoe, standard stiletto, comfy trainer
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Osteoarthritis
Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.
The Purpose of this trial is to evaluate the use of a cross-over trial design in an osteoarthritis population. We will determine the inter- and intra-subject variability in osteoarthritis (OA) endpoints and evaluate if efficacy…
- Trial name
- NCT00484718
- Testing
- celecoxib, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Pfizer
Fibromyalgia
Virtual Reality and Meditation for Fibromyalgia
Fibromyalgia (FM) is a particularly debilitating rheumatological syndrome which affects millions of adults in the United States.
- Trial name
- NCT05512650
- Testing
- Virtual Reality Meditation, Non-VR Meditation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Tufts University
Osteoarthritis, Knee / Osteoarthritis, Hip
Efficacy and Safety of MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain
The objective of this study is to verify the superiority of 16 weeks of MT-5547 treatment to placebo, as evidenced by the WOMAC pain score (the efficacy outcome measure), in patients with osteoarthritis of the knee or hip.
- Trial name
- NCT03245008
- Testing
- MT-5547
- Where
- 27 sites in Japan
- Volunteers
- 626 people
- Sponsor
- Tanabe Pharma Corporation
Shoulder Pain
Randomized Controlled Trail for Post Laparoscopic Pain
Laparoscopic surgery is becoming a major procedure, owing to smaller incisions, shorter hospitalizations, and less post-operative pain as compared with traditional laparotomies.
- Trial name
- NCT02745574
- Testing
- Combined maneuver, Intraperitoneal infusion
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Healthy, Musculoskeletal Pain
Pain Modulatory Profiles in Massage for Healthy Participants
One in ten adults experience widespread pain. Neck pain, for example, is a prevalent condition with a high rate of recurrence that affects between 10.4% and 21.3% of the population annually.
- Trial name
- NCT03490474
- Testing
- Pain Inducing Massage, Pain Free Massage, Coldpressor
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Knee Osteoarthritis
Exercise Therapy in Patients With Knee Osteoarthritis
Osteoarthritis (OA) is one of the most common form of chronic diseases in the adult population, and approximately 800 000 people in Sweden (population of 9 million people) suffer from this disease, which causes joint pain…
- Trial name
- NCT02024126
- Testing
- Exercise therapy
- Where
- Sweden
- Volunteers
- 189 people
- Sponsor
- Karolinska Institutet
Osteoarthritis
A Study to Investigate the Efficacy and Safety of GSK3196165 in Inflammatory Hand Osteoarthritis
This is a randomized, Phase IIa, multicentre, double-blind, placebo-controlled parallel group study with the primary objective to assess the efficacy potential of GSK3196165 on pain, in subjects with active inflammatory hand…
- Trial name
- NCT02683785
- Testing
- GSK3196165
- Where
- 16 sites in United States, Germany and 3 more
- Volunteers
- 44 people
- Sponsor
- GlaxoSmithKline
Patellofemoral Pain Syndrome, ACL Tear
Kinematic Assessment of Human Peripheral Joints by Dynamic CT
Aim of the research project: The entire research project aims to investigate human peripheral joints (knee, foot \& ankle, elbow, wrist \& hand) by dynamic 4D radiographic imaging acquisition during real-time motion.
- Trial name
- Karma-4D (NCT04732585)
- Testing
- Physiotherapy or Surgery
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Hip Osteoarthritis
Platelet-Rich Plasma and Hip Osteoarthritis
To evaluate the effect of platelet-rich plasma (PRP) injection on pain, function and quality of life in patients with hip osteoarthritis.
- Trial name
- NCT04820231
- Testing
- intra-articular PRP injection
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Chronic Pain, Opioid Use
Neuroimaging of Opioid Phase (OPAL)
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and…
- Trial name
- OPAL (NCT05905419)
- Testing
- Opioid Phase
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
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