Clinical trials: Pain, Orofacial, open to volunteers
Temporomandibular Disorder, Orofacial Pain
An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders
Temporomandibular disorders (TMD) encompass a group of conditions involving the masticatory muscles, temporomandibular joint (TMJ), and associated structures.
- Trial name
- NCT07639944
- Testing
- Nerivio treatment
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Theranica
Chronic Orofacial Pain, Orofacial Pain
Skills Training and Relief for Orofacial Pain
Chronic orofacial pain conditions (COFP) are associated with substantial physical and psychological burden and are best treated with multidisciplinary approaches combining psychological interventions and comprehensive orofacial…
- Trial name
- STAR (NCT07802067)
- Testing
- Empowered Relief
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Kentucky
TMD/Orofacial Pain, Malocclusions
Evaluation of the Effects of Orthognathic Surgeries on the Temporomandibular Joint Using a Mandibular Movement Analyzer Device
Condylar position and mandibular motion assessment with digital facebows Arcus Digma III before and after orthognathic surgery.
- Trial name
- NCT07828041
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Orofacial Pain, Sleep Bruxism
Orofacial Pain and Oral Health-Related Quality of Life in Musicians in German Amateur Orchestras
This cross-sectional online survey investigates the prevalence of orofacial pain, sleep-related problems, and oral health-related quality of life (OHRQoL) among adult musicians who play in German amateur orchestras.
- Conditions
- Orofacial Pain, Sleep Bruxism, Oral Health Related Quality of Life (OHRQoL)
- Trial name
- OSQ-MUS (NCT07714837)
- Testing
- Questionaire
- Where
- Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Chronic Pain, Fibromyalgia
Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women
Chronic pain disproportionately affects women and may coexist with impaired bone health, particularly during midlife and after menopause.
- Conditions
- Chronic Pain, Fibromyalgia, Osteoporosis, Orofacial Pain
- Trial name
- ORION (NCT07783295)
- Testing
- Full-Spectrum Cannabis Extract 5:1 (CBD:THC)
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Associação Pan-Americana Multidisciplinar de Endocanabinologia
Temporomandibular Joint Dysfunction; Myofascial Pain Syndrome; Orofacial Pain; Musculoskeletal Disorders
Reflex Therapy of Temporomandibular Dysfunctions
This study aims to evaluate the effectiveness of dry needling in patients with functional temporomandibular pain syndrome by comparing standard rehabilitation therapy alone with therapy combined with dry needling to reduce pain…
- Trial name
- NCT07321483
- Testing
- Dry needling, Standard rehabilitation
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Palacky University
TMJ Disc Disorder, Temporomandibular Joint Disc Displacement, Without Reduction
Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ
The study aims to assess the outcomes of arthroscopic lysis and lavage procedure with and without single intra-articular injection of hyaluronic acid in managing patients with anterior disc displacement without reduction.
- Conditions
- TMJ Disc Disorder, Temporomandibular Joint Disc Displacement, Without Reduction, TMD/Orofacial Pain, Temporomandibular Disorder
- Trial name
- NCT07614932
- Testing
- Arthroscopic lysis and lavage, arthroscopic lysis and lavage with intra-articular injection of hyaluronic acid
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Orthodontic Discomfort, Pain, Orofacial
Comparison of Patient-reported Pain After Initial Archwire Placement
Three different types of 'archwires' can be used in Orthodontic treatment, wire choice is decided by treating Orthodontist based on professional preference since research shows that all types are equally effective.
- Trial name
- Archwires (NCT03906422)
- Testing
- 3M Unitek 0.016 orthodontic archwire, Device: 0.016" Ormco 27oC NiTi orthodontic archwire, Device: 0.016" Ormco 35oC NiTi orthodontic archwire
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pain, Orofacial
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a…
- Trial name
- NCT04059172
- Testing
- Ibuprofen 200 mg and acetaminphen 650 mg, Ibuprofen 200 mg
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Trigeminal Neuralgia (TN), Orofacial Pain
Identification of Possible Trigeminal Neuralgia
Trigeminal neuralgia (TN) is a severe type of non-dental orofacial pain that can feel like sudden electric shocks in the face and is often mistaken for tooth pain or other dental problems.
- Conditions
- Trigeminal Neuralgia (TN), Orofacial Pain, Dental Pain, Questionnaire
- Trial name
- IDTN (NCT07453511)
- Testing
- Completion of the IDTN Questionnaire
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University College, London
Temporomandibular Disorders (TMD), Orofacial Pain
Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders
Dentists and physiotherapists have two options for treating these conditions: splint therapy and physiotherapy. Right now, the gold standard is individual physiotherapy, which contains manual therapy and active exercises too.
- Conditions
- Temporomandibular Disorders (TMD), Orofacial Pain, Temporo-mandibular Dysfunction, Temporomandibular Joint and Muscle Disorder
- Trial name
- NCT07474662
- Testing
- Individual physiotherapy, Group physiotherapy, Online physiotherapy
- Where
- 2 sites in Hungary
- Volunteers
- 90 people
- Sponsor
- Semmelweis University
Myalgia, Muscle Pain
The Effectiveness of CBD and CBN in the Treatment of Facial Pain and Headache of Muscular Origin
The aim of the study is to evaluate the effectiveness of an aqueous solution containing CBD and CBN in the management of Facial Pain and Headache of Muscular Origin.
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT05961501
- Testing
- An aqueous solution containing CBD and CBN
- Where
- Poland
- Volunteers
- 42 people
- Sponsor
- Wroclaw Medical University
Myalgia, Muscle Pain
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin
The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with…
- Conditions
- Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension
- Trial name
- NCT06405646
- Testing
- Blood CB1, CB2, TRPV-1 concentration measurement
- Where
- Poland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Orofacial Pain
Evaluation of the Efficacy of Neuromodulation in the Control of Chronic Orofacial Pain
Chronic orofacial pain significantly affects patients' quality of life, compromising essential functions such as chewing and speech.
- Trial name
- NeuroFace (NCT07352384)
- Testing
- Active Neuromodulation (tDCS or TMS)
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Chronic Primary Orofacial Pain (CPOP), Persistent Idiopathic Facial Pain (PIFP)
An Innovative Cognitive-Behavioral Treatment For Chronic Orofacial Pain
Use these resources to provide understandable information about this study to patients, families, and health care providers: The present randomized clinical trial (RCT), conducted at the IRCCS Carlo Besta Neurological Institute…
- Trial name
- FACE-PRT (NCT07123233)
- Testing
- Pain Reprocessing Therapy, Usual Therapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Burning Mouth Syndrome, Orofacial Pain
Burning Mouth Syndrome: Effects of Occlusal Splint Therapy
Burning Mouth Syndrome (BMS) causes chronic oral pain and significantly affects quality of life. Effective treatments are limited and often provide only temporary relief.
- Conditions
- Burning Mouth Syndrome, Orofacial Pain, Mouth Dryness
- Trial name
- NCT07344909
- Testing
- Essix splint
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Malmö University
TMD, TMD/Orofacial Pain
Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions
The goal of this clinical trial is to learn if orofacial exercises works to treat temporomandibular disorders in adults. It will also learn about the safety of orofacial exercises on temporomandibular disorders.
- Trial name
- NCT07304557
- Testing
- Exercise, Manual therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Tayfun ISIK
Chronic Orofacial Pain, Temporomandibular Disorder (TMD)
Orofacial Pain Self-management: Personality Moderation Effect
The objective of this clinical trial is to study the effect of self-management on pain perception in patients with chronic orofacial pain and temporomandibular disorders (TMD) comparing it with the conventional treatment proposed…
- Conditions
- Chronic Orofacial Pain, Temporomandibular Disorder (TMD), Temporomandibular Disorders (TMD), Temporomandibular Dysfunction (TMD)
- Trial name
- NCT06932406
- Testing
- Self-management intervention, Clinical Practice Guideline Intervention
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Orofacial Pain
Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain
A prospective, randomized, double-blind clinical trial comparing the safety and efficacy of intravenous lidocaine, ketamine, and their combination as treatment options for patients suffering from treatment-resistant orofacial…
- Trial name
- NCT07250867
- Testing
- Lidocaine Intravenous Infusion, Ketamine intravenous infusion, Combined lidocaine and ketamine intravenous infusion
- Volunteers
- 105 people
- Sponsor
- Assiut University
Orofacial Pain, Bruxism
Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain
To evaluate the clinical effectiveness of chlorzoxazone in comparison to orphenadrine Citrate in relieving the orofacial pain in bruxers.
- Trial name
- NCT07109882
- Testing
- Chlorzoxazone, Orphenadrine Citrate
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Baghdad