Clinical trials: Pain, Perioperative
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Acute Pain, Hyperalgesia
IV Acetaminophen as an Adjunct Analgesic in Cardiac Surgery
Patients undergoing cardiac surgery experience significant postoperative pain, which may impact postoperative outcomes. The aim of this single center, double-blind, randomized, placebo controlled trial is to determine if…
- Trial name
- CarDolMev (NCT01544062)
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Washington
Postoperative Pain
Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion
Blinded study using oral gabapentin in load pre-operative (15mg/kg) and maintenance 5mg/kg three times a day (TID) for 5 days or discharge, Patient Controlled Analgesia (PCA) morphine and placebo group with similar pills, also…
- Trial name
- NCT00726999
- Testing
- Gabapentin, Morphine
- Volunteers
- 63 people
- Sponsor
- Medical College of Wisconsin
Head and Neck Cancer, Acute Pain
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Patient satisfaction with healthcare is increasingly being utilized as a metric to reflect provider and hospital quality of care.
- Conditions
- Head and Neck Cancer, Acute Pain, Postoperative Pain
- Trial name
- GABA (NCT02926573)
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Pain, Postoperative
Toradol v. Celecoxib for Postoperative Pain
Randomized control trial between ketorolac versus celecoxib for postoperative pain following hysterectomy.
- Trial name
- POP (NCT03331315)
- Testing
- Celecoxib, Ketorolac
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Michael Ulm, MD
Post Operative Pain, Hyperalgesia
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery.
- Trial name
- NCT01594047
- Testing
- ketamine infusion, Methadone PCA
- Where
- Italy
- Volunteers
- 113 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Pelvic Organ Prolapse, Perioperative/Postoperative Complications
Preoperative Gabapentin vs Placebo for Vaginal Prolapse Surgery
This study will recruit women scheduled to undergo vaginal apical suspension surgery (either uterosacral ligament suspension or sacrospinous ligament fixation) with or without other prolapse or anti-incontinence procedures.
- Trial name
- NCT05658887
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Joseph Kowalski
Chronic Pain
Pregabalin and Post-thoracotomy Pain
With Institutional Ethics Board approval and signed informed consent, a pilot investigation was conducted in which 15 adult patients scheduled to undergo a thoractomy were randomly assigned to receive 1) 150 mg pregabalin 1 hour…
- Trial name
- NCT00663962
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Queen's University
Pain, Postoperative
Perioperative Administration of Pregabalin for Pain After Mastectomy
The investigators hypothesize that pregabalin will decrease post-operative pain scores and analgesic use following total mastectomy compared to placebo.
- Trial name
- NCT00938548
- Testing
- Pregabalin
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Severance Hospital
Acute Pain, Chronic Pain
Dexamethasone and Pain Following Total Knee Arthroplasty
The purpose of the study is three fold. First to determine the ideal dose of dexamethasone intraoperatively that will reduce acute pain and opioid consumption.
- Trial name
- NCT02271698
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Abdominal Hysterectomy (& Wertheim)
Lidocaine and Ketamine in Abdominal Surgery
This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy.
- Trial name
- NCT00721110
- Testing
- Lidocaine, Ketamine, Ketamine + Lidocaine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Head and Neck Cancer, Analgesia
Multimodal Pain Study in Free Flap Patients
This study will be a randomized, prospective study comparing Pain Management Arm A and Pain Management Arm B. Arm A will have scheduled Tylenol with opioids available as needed (PRN) in the peri-operative period.
- Trial name
- NCT04246697
- Testing
- Tylenol, Oxycodone, Morphine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Foot and Ankle Procedures
Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery
The purpose of this research study to evaluate the effects of dexamethasone as an addition to peripheral nerve block (Put the nerve to sleep with Bupivacaine a numbing medication) on length of pain relief (analgesia)…
- Trial name
- NCT01975285
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Pain, Postoperative, Chronic Postoperative Pain
Analgesia in Laparoscopic Cholecystectomy
The investigators hypothesis is that perioperative infusion of 0.75 ropivacaine in patients undergoing laparoscopic cholecystectomy may modify the intensity of postoperative pain or the analgesic consumption during the first 24…
- Trial name
- NCT01388946
- Testing
- Ropivacaine 0.75, Normal saline
- Where
- 2 sites in Greece
- Volunteers
- 110 people
- Sponsor
- University of Athens
Postoperative Pain, Delirium
Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery
Pain, confusion, and breaks in normal sleep cycles have been challenges commonly faced by patients after undergoing joint surgeries.
- Conditions
- Postoperative Pain, Delirium, Confusion, Sleep
- Trial name
- NCT01505465
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Laparoscopic Gastric Bypass Surgery, Ketamine
Perioperative Ketamine for Pain With Gastric Bypass
Opioid medications such as morphine, hydrocodone and oxycodone are standard for treating pain after surgery, however there are disadvantages.
- Trial name
- NCT03448068
- Testing
- Ketamine, Standard therapy
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pain
Perioperative Pain Management In Spine Surgery Patients: Part I
The purpose of this study is a comparison of pain management in opioid-tolerant spine surgery patients using a perioperative dosing goal of 150% of patient's baseline oral morphine equivalent (OME), as compared to standard…
- Trial name
- NCT01447888
- Testing
- 150% Oral Morphine Equivalent (OME), Clinical Judgment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Allina Health System
Post Operative Analgesia, Bariatric Surgery
Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients
Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism.
- Conditions
- Post Operative Analgesia, Bariatric Surgery, Bariatric Surgery (Gastric Bypass), Bariatric Surgery Patients
- Trial name
- NCT06658574
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rutgers, The State University of New Jersey
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Post Operative Pain, Nausea
Effects of Perioperative Intravenous Dexamethasone on Pain in Out Patient Knee Surgery
The purpose of the study is to determine the opiate sparing effects of intravenously administered dexamethasone in outpatient knee surgery. Dexamethasone is a glucocorticoid with well known antiemetic effects.
- Trial name
- NCT01149616
- Testing
- Dexamethasone 8mg iv x1
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center