Clinical trials: Pain, Post Surgical
Pain, Postoperative, Tonsillar Bleeding
Dexamethasone and Postoperative Bleeding Following Tonsillectomy in Children
Tonsillectomy is one of the most frequently performed surgical interventions in children. However, it is associated with a high incidence of PostOperative Nausea and Vomiting (PONV), severe pain and haemorrhage.
- Conditions
- Pain, Postoperative, Tonsillar Bleeding, Postoperative Nausea and Vomiting
- Trial name
- Blueberry (NCT04188431)
- Testing
- Dexamethasone, Sodium chloride
- Where
- 2 sites in Canada, Switzerland
- Volunteers
- 523 people
- Sponsor
- Walid HABRE
Postoperative Recovery, Lumbar Disc Herniation
Lower Back Muscle Size and Recovery After Lumbar Disc Herniation Surgery
Recovery after surgery for a herniated disc in the lower back differs from person to person. The size of the muscles around the lower spine may be related to recovery, but this relationship is not well understood.
- Trial name
- NCT07768241
- Testing
- Preoperative Psoas and Multifidus Muscle Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Knee Arthroplasty, Pain Management
Gonyautoxins Local Periarticular Injection for Pain Management After Total Knee Arthroplasty
The aim of this study is to demostrate the eficcacy in pain control management after total knee arthroplasty of Gonyautoxin. Local administration during surgery of Gonyautoxin before wound closure can achieved better pain control…
- Trial name
- Toxin (NCT03025594)
- Testing
- Gonyautoxins, Chirocaine ketorolac epinephrine
- Where
- 2 sites in Chile
- Volunteers
- 64 people
- Sponsor
- maximiliano barahona vasquez
LOS, Postoperative Pain
Effects of Methylprednisolone After Total Hip Arthroplasty
The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after hip arthroplasty.
- Conditions
- LOS, Postoperative Pain, Postoperative Nausea and Vomiting, Sleeping Quality
- Trial name
- NCT00968903
- Testing
- Methylprednisolone
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Postoperative Pain
Effect of Perioperative Oral Pregabalin in Total Knee Replacement
This interventional randomized control trial aim to determine efficacy and safety of Oral pregabalin in improving after surgery pain control in patients undergoing total knee replacement surgeries under regional anesthesia.
- Trial name
- TKR (NCT06187922)
- Testing
- Pregabalin 75mg, adductor canal block
- Where
- Bahrain
- Volunteers
- 120 people
- Sponsor
- Bahrain Defence Force Hospital
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis
Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth.
- Trial name
- SIPDEX (NCT07672873)
- Testing
- Saline (0.9%, sterile, for infusion), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Marmara University
Hemorrhoids, Pain, Postoperative
HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial
HYPOTHESIS 1. HAL- RAR causes a lower immediate postoperative pain compared with excision hemorrhoidectomy. 2. HAL - RAR achieves similar immediate and long term results compared to the excision hemorrhoidectomy in the control of…
- Trial name
- NCT02216305
- Testing
- Hemorrhoidectomy, HAL-RAR
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Plató
Chronic Postoperative Pain
euCPSP: European Observational Study on Chronic Post Surgical Pain,PAIN-OUT Study
This project a European observational study on the incidence and characteristics of chronic post surgical pain (CPSP). Research Questions What is the incidence of chronic post surgical pain (CPSP) in Europe? What are the risk…
- Trial name
- PAIN-OUT (NCT01467102)
- Where
- 24 sites in Belgium, France and 9 more
- Volunteers
- 3,618 people, healthy volunteers welcome
- Sponsor
- European Society of Anaesthesiology
Postoperative Pain
The Effect of Adding Nalbuphine to Intrathecal Morphine on Analgesic Efficacy and Side Effects After Cesarean Section
The primary endpoint of this study is to investigate the effect of adding nalbuphine to intrathecal morphine on quality of postoperative analgesia and Morphine related side effects post- cesarean delivery.
- Trial name
- NCT02716129
- Testing
- Morphine, Morphine plus Nalbuphine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Abdelrady S Ibrahim, MD
Postoperative Pain
Comparison of Interpectoral+Serratus Anterior Block With Erector Spinae Block in Minimally Invasive Cardiac Surgery
Adequate pain management after minimally invasive cardiac surgery is essential for early ambulation and patient satisfaction. However, an incision similar to thoracotomy surgery is made by entering between the ribs, and a…
- Trial name
- NCT05743231
- Testing
- interpectoral area block + serratus anterior area block group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Lumbar Spinal Stenosis, Lumbar Spondylolisthesis
Cognitive Behavioral Therapy (CBT) After Lumbar Spinal Fusion in Patients With High Pain Catastrophizing
Catastrophizing has emerged as the strongest independent predictor for persistent postsurgical pain. Although behavioral interventions, including Cognitive Behavioral Therapy (CBT), have been shown to reduce the impact of…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Lumbar Instability, Spinal Disease
- Trial name
- TRIBECA (NCT03969602)
- Testing
- Cognitive-behavioral Therapy, Biomedical and surgery-specific education
- Where
- Switzerland
- Volunteers
- 126 people
- Sponsor
- Neurocenter of Southern Switzerland
Achalasia
Post Operative Pain Control of POEM Procedure
Peroral endoscopic myotomy (POEM) is a minimally invasive treatment for esophageal achalasia with a natural orifice transluminal endoscopic procedure and far less invasive than the standard surgical or laparoscopic Heller myotomy…
- Trial name
- NCT04177342
- Testing
- Fentanyl, Oxycodone
- Volunteers
- 196 people
- Sponsor
- Chen Wannan
Postoperative Pain, Cardiac Surgery
The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery
The purpose of this randomized controlled trial is to evaluate the effect of acupressure on respiratory performance and pain levels in adult patients who have undergone open-heart surgery.
- Conditions
- Postoperative Pain, Cardiac Surgery, Postoperative Complications
- Trial name
- NCT07771751
- Testing
- Acupressure, Incentive spirometry
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Fenerbahce University
Pain, Postoperative, Opioid Use
Impact of Counseling and Education on Opioid Consumption After ACL Reconstruction
Research question: Does an opioid limiting pain management counseling and education program result in decreased opioid consumption and improved pain control compared to traditional pain management programs after anterior cruciate…
- Trial name
- CARE (NCT04885231)
- Testing
- Perioperative Pain Management Education and Counseling
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Maryland, Baltimore
Postoperative Pain
Postoperative Discomfort After Dental General Anesthesia
The aim of this prospective, randomised, controlled clinical trial was to compare immediate postoperative discomfort, emergence delirium and recovery time of the patients intubated using either laryngeal mask airway or…
- Trial name
- NCT03197753
- Testing
- Laryngeal mask airway, Nasotracheal intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Pain
Lidocaine and Outpatient Gynecologic Laparoscopy
Although ambulatory gynecological laparoscopy is considered to be a minimally invasive surgical procedure, only 60% of patients undergoing this procedure are satisfied with postoperative pain control.
- Trial name
- NCT01250002
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
İnguinal Hernia, Complication,Postoperative
Post-Surgical Outcomes of Conventional vs 3-Point Mesh Fixation in Lichtenstein Repair: An RCT
This is a single-center, parallel-group randomized controlled trial conducted in 2025-2025 at the General Surgery Ward of the Sindh Institute of Urology and Transplantation (SIUT), Karachi.
- Conditions
- İnguinal Hernia, Complication,Postoperative, Pain, Postoperative
- Trial name
- COMET (NCT07334548)
- Testing
- 3-point mesh fixation, Conventional Mesh Fixation
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Sahar Mughis
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Cold and Compression Post TKA
The purpose of this study is to compare pain score (Patient-Reported Outcomes Measurement Information System: PROMIS NRS Pain Subscale) between the control and cold/compression groups pre-surgically, daily after surgery for 14…
- Trial name
- NCT07023185
- Testing
- Cold and Compression, SOC (Standard of care)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ochsner Health System
Postoperative Pain
The Effect of Intraoperative Magnesium Sulfate Infusion on the Postoperative Recovery
Evaluating analgesic effect of intraoperative magnesium sulfate infusion in the outpatient surgery case
- Trial name
- NCT03206008
- Testing
- Magnesium Sulfate, Normal saline
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
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