Clinical trials: Pain, Post Surgical
Perioperative Anxiety, Postoperative Pain
Perioperative Effect of Music in Patients Undergoing General Anesthesia
Anxiety is a transient emotional state characterized by feelings of tension, apprehension, nervousness, fear, and heightened activation of the autonomic nervous system in response to a specific current or potential event or…
- Trial name
- EMBAG (NCT05572437)
- Testing
- Music Therapy
- Where
- Spain
- Volunteers
- 151 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Postoperative Pain
ESP Blocks for Posterior Spinal Fusion
This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion.
- Trial name
- NCT07228039
- Testing
- ESP Block with Bupivacaine, ESP Block with Bupivacaine + Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Postoperative Pain
Local Infiltration Analgesia Following Total Knee Arthroplasty
The primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect morphine consumption.
- Trial name
- RAK-total (NCT00799175)
- Testing
- ropivacaine, ketorolac and epinephrine, saline
- Where
- 2 sites in Sweden
- Volunteers
- 48 people
- Sponsor
- Region Örebro County
Irreversible Pulpitis, Apical Periodontitis
Effect of Different Methods of Cryotherapy Applications on Postoperative Pain and Substance P Level in Patients With Acute Irreversible Pulpitis With Apical Periodontitis: A Randomized Controlled Trial
This randomized controlled clinical trial evaluates the effect of different methods of cryotherapy (extra-oral, intra-canal, and combination) on postoperative pain and periapical Substance P levels in patients with acute…
- Trial name
- NCT07904312
- Testing
- Extra-oral Cryotherapy, Intra-canal Cryotherapy, Combination (extra-oral and intra-canal)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ahmad badrah
ACL Tear, ACL
Comparing Adductor Canal Block and Adductor Canal Block-Local Infiltration Analgesia for Post-operative Pain Management
Anterior cruciate ligament (ACL) reconstruction is one of the most commonly performed surgeries amongst young orthopedic surgery patients.
- Conditions
- ACL Tear, ACL, ACL Injury
- Trial name
- NCT04721119
- Testing
- Local Infiltration Anesthetic, Local Infiltration Anesthetic + Adductor Canal Block
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Poststernotomy Pain
Bilateral Pecto-Intercostal Fascial Plane Block for Prevention of Chronic Poststernotomy Pain After CABG
This single-center, prospective, parallel-group randomized controlled trial will evaluate whether adding ultrasound-guided bilateral single-shot pecto-intercostal fascial plane block (PIFB) to standard multimodal systemic…
- Trial name
- NCT07882836
- Testing
- Pecto-Intercostal Fascial Plane Block, Standardized Multimodal Systemic Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Izmir Katip Celebi University
Venous Insufficiency of Leg, Venous Reflux
Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting
The purpose of this study is to evaluate the effectiveness of Vasculera in reducing post procedural pain, bruising and edema in the post procedure period for patients diagnosed with C2-C5 disease requiring an intervention(s).
- Conditions
- Venous Insufficiency of Leg, Venous Reflux, Varicose Veins, Lower Extremity Edema Chronic
- Trial name
- NCT02936271
- Testing
- Vasculera
- Where
- United States
- Sponsor
- Corewell Health West
Postoperative Pain, Rotator Cuff Injuries
US-Guided Preemptive Brachial Plexus Blockade May Reduce Post-operative Pain: a Randomized Study
Intense e recurrent nociceptive stimulation, which occurs in the postoperatively, can trigger sensitization of the peripheral and central nociceptive pathway, leading to chronic pain.
- Trial name
- NCT04005534
- Testing
- Standard group, Preemptive group
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo General Hospital
Neuropathic Pain
Epidemiologic Multicentre Study of Neuropathic Post-surgical Pain
This cohort study aims to know the prevalence at 3 and 6 months after surgery, of persistent pain, as well as to describe the neuropathic features of this pain.
- Trial name
- EDONIS (NCT00812734)
- Testing
- Blood sampling for genomics; harvesting of a sample of intercostal muscle for proteomics (thoracotomies only)
- Where
- France
- Volunteers
- 3,322 people
- Sponsor
- University Hospital, Clermont-Ferrand
Obstructive Sleep Apnea, Postoperative Pain
Effect of Sleep Apnea on Pain After Dental Treatment
This observational study aims to investigate the effects of sleep quality and systemic health status on pain levels following endodontic treatment in adult patients.
- Conditions
- Obstructive Sleep Apnea, Postoperative Pain, Hypertension Complicated With Type 2 Diabetes
- Trial name
- OSA-EndoPain (NCT07581964)
- Testing
- Standard Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Pain, Acute Postoperative
Comparison Of Outcome Of Wound Closure After Thyroid Surgery With And Without Platysma Suturing
Comparison Of Outcome Of Wound Closure After Thyroid Surgery With And Without Platysma Suturing in terms of wound scar and pain.
- Trial name
- NCT06485011
- Testing
- Paltysma suturing, Without Platysma suturing
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Children Hospital and Institute of Child Health, Lahore
Hemorrhoids
Effect of Topical Trimebutine on Pain After Hemorrhoidectomy
Trimebutine acts through smooth muscle relaxation. It is presumed that the topical application of trimebutine after hemorrhoidectomy may help relieve pain after the procedure by relaxing the internal anal sphincter spasm.
- Trial name
- NCT03036111
- Testing
- Trimebutine, Hemorrhoidectomy
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Mansoura University
Cerebral Palsy, Post-operative Pain
The Post-Operative Pain in Cerebral Palsy (POPPIES) Trial
Cerebral palsy is common. It affects approximately 3 per 1000 children. Hip displacement due to muscle tightness (spasticity) occurs in up to half of the more severely affected children, and many of these children require major…
- Trial name
- POPPIES (NCT01437644)
- Testing
- botulinum toxin intramuscular injection
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Breast Cancer
Continues Cicatricial Perfusion of Ropivacaine Versus Placebo After Mastectomy : Rehabilitation After Treatment
The acute pain care, in particular after breast cancer surgery must be early and quickly effective, because a severe postoperative pain increases the risk of chronic pain and exposes to a risk of important embarrassment for the…
- Trial name
- NCT02525211
- Testing
- Ropivacaine, physiological saline
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Institut Paoli-Calmettes
Opioid Use, Unspecified, Pain, Postoperative
Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery
Being relatively new, the NOL monitor may offer interesting observations in perioperative nociception levels and appropriate analgesic consumption in diverse surgeries, including robot-assisted surgery.
- Trial name
- NCT05662371
- Testing
- Nociception Level monitor (NOL), Standard care
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Southern Denmark
Video Assisted Thoracoscopic Surgery, Pain, Postoperative
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
The purpose of this study is to compare three different pain control methods on subjects who are scheduled to undergo VATS (video-assisted thoracoscopic surgery) procedures.
- Conditions
- Video Assisted Thoracoscopic Surgery, Pain, Postoperative, Pain, Acute
- Trial name
- VATS (NCT03151434)
- Testing
- US Guided Single Shot Paravertebral Block (0.2% ropivicaine infusion), US Guided Paravertebral Catheter (0.2% ropivicaine bolus), Thoracic Epidural (0.125% bupivicaine/hydromorphone)
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Indiana University
Post Operative Pain, Opioid Side Effects
Find the Adequate Dose of Nalbuphine for Laparoscopic Cholecystectomy
This study evaluate the adequate dose of mutonpain for laparoscopic cholecystectomy in the management of post operative pain. The investigators will randomize patients into three groups to compare the analgesia effects and side…
- Trial name
- NCT04135534
- Testing
- group A, group B, group C
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Thoracic, Surgery
Opioid-free Anesthesia in Thoracic Surgery
No study has been conducted to demonstrate the feasibility and safety of an Opioid-Free Anesthesia (OFA) protocol compared to Opioid-Based Anesthesia (OBA) in thoracic surgery, at risk for intense post-operative pain, to improve…
- Trial name
- VATOFA (NCT04246099)
- Testing
- Post-operative care
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Other Acute Postoperative Pain, Prolonged Endotracheal Intubation
Pharmacokinetics, Safety, and Efficacy of Intravenous Dosing of Buprenorphine in Pediatric Patients Who Require Opioid Analgesia for Acute Moderate to Severe Pain
The purpose of this study is to characterize the safety, pharmacokinetics (PK), and efficacy of intravenous (IV) buprenorphine in pediatric patients.
- Trial name
- NCT01324544
- Testing
- Buprenorphine IV
- Sponsor
- Purdue Pharma LP
Postoperative Pain
Ultrasound Guided ESP Block Versus Intrathecal Morphine for Postoperative Analgesia in Major HPB Surgery.
To compare the efficacy of USG-guided bilateral Erector spinae plane block (ESPB) with intrathecal morphine (ITM) for postoperative analgesia after major hepatopancreaticobiliary surgery (HPB)
- Trial name
- NCT04635644
- Testing
- Erector Spinae Plane Block, Intrathecal morphine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
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