Clinical trials: Pain
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Postoperative Pain
Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques?
This is a randomized noninferiority interventional study to determine the equivalence of two adductor canal block (ACB) methods: mid-thigh and distal thigh in patients undergoing medial foot, medial ankle, or medial leg surgery.
- Trial name
- NCT02788019
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pain, Postoperative, Numbness
Lidocaine Versus Bupivacaine in Orthognathic Surgery
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery.
- Conditions
- Pain, Postoperative, Numbness, Temperature Sensation, Perception of Touch
- Trial name
- NCT06450028
- Testing
- 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Intractable Neuropathic Pain, Pain
Spinal Cord Stimulation (SCS) for Neuropathic Pain of Back or Lower Extremity
The primary objective of this study is to compare the efficacy and patient preference for spinal cord stimulation (SCS) using the Precision device with the electrode array placed at T7 versus placement at T8.
- Conditions
- Intractable Neuropathic Pain, Pain, Back Pain, Lower Extremity Pain
- Trial name
- NCT00399841
- Testing
- Precision for Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Boston Scientific Corporation
Pain, Advanced Cancer
Sativex® for Relieving Persistent Pain in Participants With Advanced Cancer
This 9-week study aimed to determine the efficacy, safety and tolerability of nabiximols (Sativex®) as an adjunctive treatment, compared with placebo in relieving uncontrolled persistent chronic pain in participants with advanced…
- Trial name
- NCT01262651
- Testing
- Nabiximols
- Where
- 72 sites in United States, Belgium and 10 more
- Volunteers
- 397 people
- Sponsor
- GW Pharmaceuticals Ltd
Other Acute Pain
An Efficacy and Safety Trial of Intranasal Ketorolac in Emergency Department Patients for the Treatment of Acute Pain
The purpose of this study is to determine the effectiveness, the safety, and the tolerability of intranasal ketorolac (Sprix) in relieving acute pain in adults ages 18-65 who come to the ED seeking care.
- Trial name
- Sprix (NCT01471639)
- Testing
- intranasal ketorolac
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- The Cleveland Clinic
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty(Postoperative Pain)
Dose Dependent Effects of tDCS on Post-Operative Pain
The proper control of acute and chronic pain is one of the most important areas in health care. Despite the profound advances in neuroscience over the past 20 years, the investigators still largely use opiate narcotics, much as…
- Trial name
- tDCS-TKA (NCT02241967)
- Testing
- 4 Real sessions of Transcranial Direct Current Stimulation, 2 Real Sessions of Transcranial Direct Current Stimulation, 1 Real Session of Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development
Surgical Recovery, Pain, Postoperative
Oxidative Stress and Surgical Recovery
Chronic pain, functional impairment and slow rates of recovery are key issues for patients after surgery and trauma. No preventative strategy in current use unequivocally modifies these rates, and few novel approaches have been…
- Trial name
- NCT04732000
- Testing
- N-acetyl cysteine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Breast Cancer, Chronic Pain Due to Malignancy (Finding)
Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients
Cancer in general, and breast cancer in specific, is a significant health problem in the USA and the rest of the world. With the improvement of new surgical approaches and chemotherapies to manage breast cancer, the number of…
- Trial name
- NCT03847311
- Testing
- Sulfasalazine
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Epiphora, Dacryostenosis
Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT04229771
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Low Back Pain
Study on the Safety and Effectiveness of Switching Between Two Forms of Tapentadol in Patients With Chronic Low Back Pain
The objective of this study is to test the idea that the immediate-release (IR) form of tapentadol (CG5503) can be directly converted into an approximately equivalent total daily dose (TDD) of the extended-release (ER) form, and…
- Trial name
- NCT00594516
- Testing
- tapentadol (CG5503) Immediate Release IR, tapentadol (CG5503) Extended Release (ER), tapentadol (CG5503) Immediate Release (IR)
- Volunteers
- 117 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Postoperative Pain, Objective Assessment of Sedation
Infrared Pupillometry During General Anesthesia to Predict Pain
The study comprises of a series of pupillary measurements using infrared pupillometry in patients undergoing arthroscopic knee surgery of any type.
- Trial name
- NCT02058511
- Testing
- Anesthesia Premedication, Induction and Maintenance, Pupillometry after administration of anesthetic drugs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Back Strain, Neck Strain
Heat Versus Ice in the Acute Management of Neck and Back Strain Injuries
Muscle sprains of the back and neck are very common. In addition to pain and antiinflammatory medications the use of either cold or hot packs has been recommended.
- Trial name
- NCT01535365
- Testing
- Heat, Cold
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stony Brook University
Pain, Postoperative
Post-operative Patient Positioning Device for Improvement of Post-Operative Pain
This paucity of evidence supporting or dissuading the use of postoperative abdominal support following cesarean section for the reduction of postoperative pain leaves important clinical questions unanswered.
- Trial name
- NCT04797637
- Testing
- ABBy® Adjustable Panniculus Retractor for Wound Care
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Neck Pain, Back Pain
Cyclobenzaprine HCl Extended Release 15 mg Versus Placebo in Treatment of Cervical and/or Lower Back Pain Due to Muscle Spasms of Local Origin
The purpose of this study was to assess the effect of cyclobenzaprine hydrochloride (HCl) extended release (CER) 15 mg capsule once daily in participants with muscle spasms associated with acute painful musculoskeletal conditions.
- Conditions
- Neck Pain, Back Pain, Spasm
- Trial name
- NCT02814565
- Testing
- Cyclobenzaprine HCl
- Where
- 10 sites in Russia
- Volunteers
- 180 people
- Sponsor
- Takeda
Labor Pain
Intracutaneous Sterile Water Injections
For most women, the most significant pain they will experience is the pain associated with childbirth. Up to one-third of women experience "back labor", this typically occurs when the fetus assumes varying degrees of malposition…
- Trial name
- NCT01513447
- Testing
- Intracutaneous injections
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pelvic Organ Prolapse, Abdominal Surgery
The Effect of Abdominal Binder Use on Postoperative Pain and Mobility in Patients Undergoing Pelvic Surgery
To determine the effect of post-operative abdominal binder usage on total narcotic usage after undergoing surgery. To determine if abdominal binder usage results in decreased visual analog scale (VAS) pain scores and shorter time…
- Conditions
- Pelvic Organ Prolapse, Abdominal Surgery, Laparoscopic Surgery, Post Operative Pain
- Trial name
- NCT03684304
- Testing
- Abdominal binder
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Cataract
Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification
objective: To evaluate the efficacy of the ophthalmic emulsion PRO-145 in the treatment of inflammation and pain after phacoemulsification.
- Trial name
- PRO-145/III (NCT03693989)
- Testing
- Difluprednate 0.05%, Prednefrin
- Where
- 5 sites in Mexico
- Volunteers
- 178 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Craniotomy Surgery
Cranial Blocks for Postoperative Anesthesia
This study compares the standard of care to the standard of care plus the administration of bupivacaine or liposomal bupivacaine in patients receiving craniotomies.
- Trial name
- NCT04749797
- Testing
- Liposomal bupivacaine, Bupivacaine Injection, Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pennsylvania
Pain
Actual Use and Compliance Study Of Ibuprofen 600 Mg Immediate Release/Extended Release Tablets In At-Risk OTC Consumers
This will be an open-label, multicenter, 30-day, unsupervised AUS among targeted (at-risk) adult and adolescent consumers designed to mimic an OTC-like environment.
- Trial name
- NCT03722238
- Testing
- Ibuprofen 600 mg Immediate Release/Extended Release Caplet
- Where
- 27 sites in United States
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Pfizer
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.