Clinical trials: Pain Control
Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness
To Assess Signs and Symptoms in Women Affected by GSM After One Cycle of Pixel CO2-Alma Fractionated Laser
Genitourinary syndrome of menopause (GSM) occurs in approximately 50% of menopausal women but is both underrecognized and undertreated despite numerous treatment options.
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness, Burning, Pain
- Trial name
- NCT05156502
- Testing
- Fractionated Laser (Pixel CO2-Alma), Fractionated Laser (Pixel CO.2-Alma)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dr. Filippo Murina
Pain, Procedural, Lidocaine
Effects of Cervical Lidocaine Spray on Pain Relief During Manual Vacuum Aspiration
This randomized control trial aim to evaluate the effectiveness of local lidocaine spray application to the cervix on the reducing of pain score during the manual vacuum aspiration
- Conditions
- Pain, Procedural, Lidocaine, Obstetric Surgical Procedures
- Trial name
- NCT06344637
- Testing
- 10 % lidocaine spray without adrenaline
- Where
- Thailand
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- UdonThani Hospital
Postoperative Pain
Intravenous Ketamine and Postoperative Pain Following Cesarean Section.
The purpose of this study is to investigate the analgesic effect of low-dose intravenous ketamine in pregnant mothers undergoing cesarean section under Bupivacaine spinal anesthesia.
- Trial name
- NCT03018301
- Testing
- Ketamine, Normal saline
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pain
Epidural Morphine Versus Epidural Fentanyl Infusion Following Cesarean Section
For post-Cesarean analgesia, the investigators will compare the efficacy of single-shot epidural preservative free morphine with a continuous epidural fentanyl infusion.
- Trial name
- NCT01362998
- Testing
- Preservative free morphine, Fentanyl
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Goodman, Evan, M.D.
Pain
A Study to Evaluate the Effect of VX-548 on the QT/QTc Interval in Healthy Participants
The purpose of the study is to evaluate the effects of clinical and high clinical exposures of VX-548 and its metabolite on QTcF, and the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VX-548 and its…
- Trial name
- NCT05818852
- Testing
- VX-548, Moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
Surgery, Laparoscopic
Low Versus Standard Pressure Pneumoperitoneum on Shoulder Tip Pain
This proposed study is a single-center, double blind, parallel group RCT comparing the use of low (10 mm Hg) versus standard pressure (15 mm Hg) pneumoperitoneum at the time of benign gynecologic laparoscopic surgery.
- Conditions
- Surgery, Laparoscopic, Laparoscopy, Penumoperitoneum
- Trial name
- NCT06504277
- Testing
- Low Pressure Penumoperitoneum, Standard Pressure Group (No intervention- active comparator)
- Where
- Canada
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Adenoma, Pain
The Effects of the Water-exchanged Colonoscopy on Adenoma Detection Rate
Water exchange method has been shown to reduce medication requirement and pain experienced during colonoscopy. It may increase the adenoma detection rate (ADR).
- Trial name
- NCT02135601
- Testing
- Water colonoscopy
- Where
- 6 sites in China
- Volunteers
- 3,303 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Nitrous Oxide
Nitrous Oxide for Pain Management During In-Office Gynecology Procedures
The purpose of this study is to evaluate the pain control, patient satisfaction, and efficiency of nitrous oxide used for anesthesia during in-office gynecologic procedures compared to IV sedation.
- Trial name
- NO2 (NCT06661005)
- Testing
- Nitrous oxide, IV Sedation
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Pain, Postoperative
Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy
Hysterectomy is the most common major gynecologic surgery performed in the US and is performed for a variety of indications including malignancy, pelvic mass, endometriosis, leiomyoma, and pelvic organ prolapse.
- Trial name
- RA-TLH (NCT04429022)
- Testing
- Gabapentin, Acetaminophen, Celecoxib
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Anesthesia, Obstetrical
The Comparison Of Nerve Blocks In Cesarean Delivery
The purpose of this study is to investigate the effect of different kinds of popular peripheral nerve blocks for postoperative analgesia after cesarean delivery is completed, compared with traditional epidual analgesia.
- Trial name
- NCT03333902
- Testing
- QLB, Intravenous patient controlled analgesia (PCA)
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Feng Xia
Labor Pain
Changes in Velocimetric Indices of Uterine and Umbilical Arteries Before and After Combined Spinal-epidural Analgesia in Laboring Women (PART II)
Combined spinal-epidural (CSE) for labor analgesia has been used for many years and is practiced commonly at our institution, especially when the patient requests immediate pain relief.
- Trial name
- NCT06655675
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Urinary Retention
Effect of Voiding Position (Standing in the Shower vs. Sitting) on Post- Void Residual Urine Volume (PVR) After Removal of Urinary Catheter in Women Following Vaginal Delivery With Epidural Analgesia: A Double- Blind Randomized Controlled Trial
Postpartum urinary retention is a common complication after childbirth, with a higher risk for women who undergo vaginal delivery with epidural analgesia.
- Trial name
- NCT07893119
- Testing
- Standing in the shower, Sitting on the toilet
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assuta Ashdod Hospital
Headache, Pituitary Tumor
The TMS Treatment for Postoperative Headache in GH Tumor
Headache is a very common main complaint of patients with GH pituitary tumor, which has seriously affected the normal work and life of patients.
- Conditions
- Headache, Pituitary Tumor, Acromegaly
- Trial name
- NCT04529356
- Testing
- Transcranial magnetic stimulation, Acetaminophen
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Pain Management
Non-Pharmacological Nursing Pain Management for Preterm Infants
A randomized controlled trial will be conducted to examine the effect of non-pharmacological nursing pain management strategies in alleviating pain among preterm infants.
- Trial name
- NCT05947877
- Testing
- Non-pharmacological pain management strategies
- Where
- Iraq
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Pain
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors
This protocol is for a number of in vitro studies using human surgical biopsies and evaluating the pharmacology and genetics of human nociceptors ("pain detecting") neurons
- Trial name
- NCT00223366
- Where
- United States
- Volunteers
- 2,007 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Vaginal Discharge, Perineum; Rupture
Efficacy and Safety of the Application of Local Anaesthetic in Spray to Repair of 1st- 2nd Perineal Lacerations
Randomized controlled trial aimed at evaluating the efficacy and safety of the use of a local anesthetic spray, commonly used in clinical practice as off-label, during the suturing of perineal lacerations in post-partum…
- Conditions
- Vaginal Discharge, Perineum; Rupture, Analgesia
- Trial name
- LISPRAY (NCT05201313)
- Testing
- Lidocaine Hydrochloride, Mepivacaine Injection
- Where
- Italy
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Pain
Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
The purpose of this study is to determine if intrathecal hydromorphone will relieve pain as well as intrathecal morphine after cesarean delivery, with fewer side effects.
- Trial name
- NCT01866254
- Testing
- Hydromorphone, Morphine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Grace Shih, MD
Legal Abortion With Complication, Pain
Paracervical Block for Pain Control in First Trimester Abortion
Many woman undergoing a surgical abortion receive a paracervical nerve block for pain reduction, in which lidocaine (a numbing medication) is injected around the cervix.
- Trial name
- NCT01094366
- Testing
- Paracervical Block
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Labor Pain
Efficacy of Peanut Ball Usage on Labor Pain, Support and Control, Anxiety, and Labor Duration
*Primary: To compare the control group, women in the experimental group will have lower level of labor pain after the intervention of peanut ball usage.
- Trial name
- NCT04204395
- Testing
- Peanut Ball
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Belly Pain, GI Health
Radicle GI Health DBG: A Study Assessing the Impact of Health and Wellness Products on GI Health and Related Health Outcomes
Radicle GI Health DBG: A randomized, double-blind, placebo-controlled study assessing the impact of health and wellness products on GI health and related health outcomes.
- Trial name
- NCT07318077
- Testing
- GI Health Active Product 1, GI Health Active Product 2
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Radicle Science