Clinical trials: Pain Disorder
Chronic Pain, Low Back Pain
High Level Pulsed Heat Versus Low Level Steady Heat in Subjects With Chronic Low Back Pain
This study is a double blinded randomized active placebo controlled trial in subjects with chronic low back pain. The trial compares pain relief by a device that delivered high level pulsed heat (45 °C) to pain relief delivered…
- Conditions
- Chronic Pain, Low Back Pain, Heat, Analgesia
- Trial name
- NCT04109703
- Testing
- High Level Pulsed Heat delivered by Generation 5 devices from Soovu Labs Inc., Low Level (37 degrees C) delivered by the control device Generation 5 devices from Soovu Labs Inc.
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soovu Labs Inc.
Breast Cancer, Arthralgia
Loss of Grip Strength, BMI, and Adjuvant Endocrine Therapy Breast Cancer
Early stage hormone receptor positive breast cancer is typically treated with adjuvant endocrine therapy in order to decrease risk of breast cancer recurrence and to improve overall survival from the disease.
- Conditions
- Breast Cancer, Arthralgia, Obesity
- Trial name
- LOGRIBMET (NCT01896050)
- Testing
- anastrozole, letrozole, exemestane, Tamoxifen
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Michigan Rogel Cancer Center
Pain, Osteo Arthritis Knee
Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee
This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.
- Conditions
- Pain, Osteo Arthritis Knee, Knee Osteoarthritis, Arthritis
- Trial name
- NCT05618782
- Testing
- LEVI-04
- Where
- 13 sites in Czechia, Denmark and 3 more
- Volunteers
- 518 people
- Sponsor
- Levicept
Postoperative Pain, Postoperative Complications
Patient Morbidity After Palatal Free Gingival Grafts With or Without PRF Membranes Coverage
This study evaluates postoperative morbidity of patients that undergo free gingival graft harvesting from palate with or without use of autogenous PRF (Platelet Rich Fibrin) membranes to cover the donor site.In the Test Group…
- Conditions
- Postoperative Pain, Postoperative Complications, Gingival Recession
- Trial name
- NCT03685396
- Testing
- Platelet rich fibrin ( PRF), hemostatic agents with oxidized and regenerated cellulosa
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera San Paolo
Widespread Chronic Pain
The Maintaining Musculoskeletal Health Study
It is known from many studies that when patients have developed chronic widespread pain (CWP) or fibromyalgia that managing such symptoms is extremely challenging for both doctors and patients.
- Trial name
- MAmMOTH (NCT02668003)
- Testing
- Cognitive Behavioural Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,002 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Post-traumatic Stress Disorder, Traumatic Brain Injury
Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
In this proposal, the investigators extend their previous SPiRE feasibility and preliminary effectiveness study to examine STEP-Home efficacy in a RCT design.
- Conditions
- Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression
- Trial name
- STEP-Home (NCT03868930)
- Testing
- STEP-Home, PCGT
- Where
- 2 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Migraine
Intranasal Ketorolac Versus Intravenous Ketorolac for Treatment of Migraine Headaches in Children
Ketorolac is an evidence-based, first-line acute migraine therapy that is commonly used in the pediatric population; however, it is typically administered by the intravenous (IV) or intramuscular (IM) routes, both of which…
- Trial name
- NCT02358681
- Testing
- Ketorolac, intranasal, Ketorolac, intravenous
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Columbia University
Venous Thromboembolism
Dalteparin vs Unfractionated Heparin For The Prevention Of Venous Thromboembolism (VTE) In Hospitalized Acutely Ill Medical Patients
The purpose of this study is to compare the efficacy and safety of dalteparin vs unfractionated heparin for the prevention of VTE (Venous Thromboembolism) in hospitalized acutely ill medical patients.
- Trial name
- NCT00445328
- Testing
- Dalteparin (Fragmin), Unfractionated heparin
- Where
- 7 sites in India
- Volunteers
- 84 people
- Sponsor
- Pfizer
Osteoarthritis
Educational Intervention for Knee Pain
The purpose of this study is to demonstrate the efficacy of interventions to improve understanding of knee replacement risks, benefits, and expected outcomes among AA primary care patients, increase willingness to consider knee…
- Trial name
- NCT00324857
- Testing
- Decision Aid Video, Motivational Interviewing, MI plus Decision aid
- Where
- 3 sites in United States
- Volunteers
- 663 people
- Sponsor
- VA Office of Research and Development
Cystitis, Interstitial
Smartphone-based Self-care Education Program for Women With Interstitial Cystitis: Educational Remote IC Aide
To implement and assess clinical efficacy of a text message and multimedia-based program that (i) remotely delivers first- and second-line American Urological Association (AUA) treatments of IC/BPS; (ii) integrates treatment of…
- Trial name
- ERICA (NCT05260112)
- Testing
- ERICA
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Pennsylvania
Point-of-Care Bladder Ultrasound, Urethral Catheter
BULLET: Bladder Ultrasound Limits Length (of Time), Expedites Treatment
In this study patients presenting to the pediatric ER with abdominal or pelvic complaints will be randomized to urethral bladder catheter or bladder ultrasound to compare time to completion of successful pelvic ultrasound, as…
- Trial name
- BULLET (NCT03860311)
- Testing
- Bladder Ultrasound, Standard of Care
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Opioid Use Disorder, Chronic Pain
An Adaptive Walking Intervention to Manage Chronic Pain in Veterans With Opioid Use Disorder Engaged in Opioid Agonist Treatment
Severe chronic pain and opioid use disorder (OUD) occur at significantly higher rates in Veterans compared to the general population.
- Trial name
- NCT05051644
- Testing
- Steps 2 Change (S2C), Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Chronic Pain
Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time
The primary objective of this study is to evaluate the safety of hydrocodone extended-release tablets when used over a 12-month period in patients with chronic pain, as assessed by adverse events, clinical laboratory results…
- Trial name
- NCT01223365
- Testing
- Hydrocodone ER
- Where
- 54 sites in United States
- Volunteers
- 330 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Complex Regional Pain Syndrome I of Lower Limb
"Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Abstract: Complex regional pain syndrome (CRPS) is a significant complication in operated osteoarticular pathology and may adversely affect patient's quality of life. Vitamin C is an anti-oxidant and a neuro-modulating agent.
- Trial name
- NCT04204200
- Testing
- liposomal vitamin C, standard vitamin C
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier de Ham
Pain, Obesity
The Effect of Pre-Operative Transversus Abdominis Plane (TAP) Block in the Post Operative Opioid Consumption in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study
The use of preoperative TAP block in laparoscopic bariatric surgery can improve the postoperative pain and quality of recovery in patients undergoing these procedures.
- Conditions
- Pain, Obesity, Surgery
- Trial name
- NCT01075087
- Testing
- (study group) will receive a bilateral TAP block using 20 cc of 0.5% ropivacaine on each side.
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Pain Associated With Fibromyalgia
Treatment of Pain Associated With Fibromyalgia
The main objective of this trial is to compare change in weekly average daily pain score (ADPS) from baseline to Week 13 in participants receiving either dose of DS-5565 versus placebo.
- Trial name
- NCT02187471
- Testing
- DS-5565, Pregabalin
- Where
- 154 sites in United States, Argentina and 12 more
- Volunteers
- 1,301 people
- Sponsor
- Daiichi Sankyo
NSAID, Pain Management
Pre-emptive Analgesics in Orthodontic Treatment
This study is designed to determine if the preemptive use of a combination of acetaminophen and ibuprofen is more effective in reducing pain following orthodontic tooth movement when compared to the use of acetaminophen and…
- Trial name
- NCT03523988
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Washington
Abortion in First Trimester
Auriculotherapy - Pain Management of Aspiration Abortion
Primary Objective: To assess whether usual care plus auricular acupressure with beads reduces subject-reported maximum pain during first trimester vacuum aspiration compared to usual care plus placebo.
- Trial name
- NCT03896022
- Testing
- Acupressure with Beads, Acupuncture with Needles
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Columbia University
Chronic Migraine
Study Evaluated the Effectiveness of Milnacipran to Reduce Pain Levels in Individuals With Chronic Migraine
The purpose of this study is to determine if milnacipran taken twice daily is effective in reduction of headache pain.
- Trial name
- NCT01393522
- Testing
- Milnacipran
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Timothy Smith
Pain, Chronic Disease
Improving Chronic Pain Treatment in Primary Care
The primary objective of this study is to determine to what extent a collaborative intervention improves chronic pain-related outcomes in a VA primary care setting.
- Conditions
- Pain, Chronic Disease, Depression
- Trial name
- SEACAP (NCT00129480)
- Testing
- Assistance with Pain treatment
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- VA Office of Research and Development
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