Clinical trials: Pain Modulation
Pain Management, Sedation
The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty
The interaction of analgesia and sedation ot their effect on the prognosis of surgical patients still need to be elucidated.Currently, how to optimize intra-operative Analgesia and sedation to improve the prognosis of surgical…
- Conditions
- Pain Management, Sedation, Peripheral Nerve Block, Total Knee Arthroplasty
- Trial name
- NCT02576015
- Testing
- peri-operative continuous femoral nerve block with light sedation, post-operative continuous femoral nerve block, lidocaine
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Min Su
Fibromyalgia, Fibromyalgia Syndrome
PRL2019 in the Treatment of Juvenile Fibromyalgia
Juvenile Fibromyalgia Syndrome (JFS) is a chronic condition affecting children and adolescents, characterised by widespread musculoskeletal pain and a significant impact on daily life and quality of life.
- Trial name
- IGG-microbiota (NCT07738926)
- Testing
- Bifidobacterium adolescentis PRL2019
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Giannina Gaslini
Cervical Proprioceptive Error in Healthy Young Individuals
Proprioceptive Puzzle: Effects on Quantitative Sensory Tests and Body Awareness
Background: Cervical proprioception, referring to the awareness of the head's position in space, plays a crucial role in maintaining postural control and preventing musculoskeletal injuries.
- Trial name
- NCT06559397
- Testing
- Assessment of cervical proprioception
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nagihan Acet
Anesthesia; Hypothermia, Injection Site Irritation
Topical Ice-therapy for Intravitreal Injections
Purpose: To examine the difference in patient's pain experience in the setting of intravitreal anti-VEGF injections with pretreatment of topical ice-therapy compared with no-ice.
- Trial name
- NCT05269823
- Testing
- Ice-therapy, No Ice-therapy
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Musculoskeletal Pain, Pain, Chronic
NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)
Musculoskeletal pain represents the leading cause of disability worldwide. It has been traditionally attributed to peripheral mechanisms, but peripheral damage, inflammation, and psychological factors have failed to significantly…
- Trial name
- NEPAL (NCT02488863)
- Testing
- MRI Neuroimaging, Quantitative Sensory Testing, Questionnaires
- Where
- 4 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy
Oxytocin's Effect on Social Pain Empathy
The aim of the present experiment is to examine oxytocin's behavioral and neural effects on social pain empathy
- Trial name
- NCT03122067
- Testing
- oxytocin treatment
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy
Effects of Trancutaneous Auriculotemporal Nerve Stimulation
Neuromodulation works by either actively stimulating nerves, causing the alteration or modulation of nerve activity by delivering electrical agents directly to a target area.
- Trial name
- NCT07184190
- Testing
- Trancutaneous Auriculotemporal Nerve Stimulation
- Where
- Argentina
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Gran Rosario
Neuropathic Pain, Phantom Limb Pain
Mindful SensoriMotor Therapy With Brain Modulation in Highly Impaired Extremities
Brief summary: This single-arm, pilot clinical investigation aims to evaluate Mindful SensoriMotor Therapy (MSMT) enhanced with brain modulation as a treatment of pain due to sensorimotor impairment, such as Phantom Limb Pain…
- Trial name
- NCT04897425
- Testing
- Mindful SensoriMotor Therapy Enhanced with Brain Modulation
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Chalmers University of Technology
Pain
Placebo Modulation of Orthodontic Pain
How placebo modulates orthodontic pain remains largely unknown. The present study aimed to investigate the placebo modulation of brain activity associated with orthodontic pain using fMRI.
- Trial name
- NCT03689517
- Testing
- orthodontic elastic separators
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Migraine
Chronic Pain and Conditioned Pain Modulation After on Line-behavioral Approach
Chronic pain is a disabling condition associated with progressive changes and decline in psychological wellbeing. According with a modern conceptualization, pain has to be considered a biopsychosocial disorder where biological…
- Trial name
- Be-Home-Pain (NCT04859374)
- Testing
- Mindfullness, treatment as usual (TAU) (pharmacological)
- Volunteers
- 35 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Spinal Surgery
Understanding How Methadone Treatment During Surgery Affects Pain Levels and the Need for Pain Medications After Surgery
The researchers are doing this study to find out whether giving methadone during spinal surgery helps manage pain in the first 72 hours after surgery better than other standard pain medications.
- Trial name
- NCT05417100
- Testing
- Methadone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Fibromyalgia (FM)
Chronic Fibromyalgia Pain, Lifestyle Factors, and Inflammation
The goal of this observational study is to understand how lifestyle factors (such as diet, physical activity, sleep, stress, smoking, and alcohol intake) predict changes in pain sensitivity and modulation in adults aged 18-65…
- Trial name
- BUFS (NCT07074275)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Bournemouth University
Healthy, Tooth Extraction
Pain Pathways in the Brain
This study will evaluate brain pathways involved in feeling pain and pain relief following administration of pain medication. Magnetic resonance imaging (MRI) will be used to measure brain activity at sites that become more…
- Trial name
- NCT00078364
- Testing
- MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Healthy
QST in Context With Conditioned Pain Modulation
Conditioned Pain Modulation (CPM) is a phenomenon which isn't examined enough. Many factors of influence such as gender, age and psyche are already known - but the duration of such effects, their reliability and the correlation…
- Trial name
- CPM (NCT01618604)
- Testing
- Quantitative Sensory Testing, Conditioned Pain Modulation, Repetition of four QST parameters
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Fibromyalgia Syndrome
Impact of Auditory Environments on Pain in Fibromyalgia: a 4×4 Crossover Trial
This study examines whether different types of sounds can help reduce pain in people with fibromyalgia, a chronic condition that causes widespread pain and increased sensitivity to sensory experiences.
- Trial name
- SoundsPainFM (NCT07037134)
- Testing
- Natural soundscape exposure, Urban soundscape exposure, Broadband sound exposure
- Where
- Spain
- Volunteers
- 88 people
- Sponsor
- Universidad de Granada
Painful Diabetic Neuropathy
Treatment for Painful Diabetic Neuropathy
Painful diabetic neuropathy (pDN) occurs in a subset of diabetic patients, and is characterize by burning, shooting, and electric shock-like pain in the arms and legs.
- Trial name
- NCT05937984
- Testing
- Active Controlled Transcranial Magnetic Stimulation (cTMS)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Burn Injury, Chronic Pain
Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain and itching associated with burn injury. This study is part of the Boston-Harvard Burn Model System.
- Conditions
- Burn Injury, Chronic Pain, Pruritus, Itching
- Trial name
- NCT01795079
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Spaulding Rehabilitation Hospital
Pain
Cannabinoid Modulation of Pain
The purpose of this study is to test the effects of cannabinoids on pain response using a variety of human experimental pain models.
- Trial name
- NCT01595620
- Testing
- Thermal, Electrical, Capsaicin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Pain, Hyperalgesia
Analgesic Effect of Oxytocin Receptor Modulation
Carbetocin is a synthetic analogue of the hormone Oxytocin and is routinely used in obstetric anesthesiology to control uterine bleeding after cesarean section.
- Conditions
- Pain, Hyperalgesia, Central Sensitization
- Trial name
- NCT01918475
- Testing
- Carbetocin
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Pain
A Study on the Efficacy of Dual-Carrier-Frequency Transcranial Alternating Current Stimulation Modulating the Hippocampus for the Treatment of Chronic Non-Specific Low Back Pain
This is a single-center, randomized, double-blind, sham-controlled trial evaluating dual-carrier-frequency transcranial alternating current stimulation targeting the hippocampus in 60 patients with chronic non-specific low back…
- Trial name
- NCT07832188
- Testing
- Dual-carrier-frequency transcranial alternating current stimulation, Transcranial electrical stimulation (tES)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qilu Hospital of Shandong University