Clinical trials: Pain Reduction, open to volunteers
Adolescent Idiopathic Scoliosis (AIS)
Hypnosis for Pain and Nausea Reduction in Scoliosis Surgery: An Interventional Study
This study evaluates whether preoperative hypnosis can reduce postoperative pain, nausea, and opioid use in adolescents undergoing scoliosis surgery. Participants aged 12-18 years will receive hypnosis training before surgery.
- Trial name
- HYP-SCOL (NCT07854951)
- Testing
- Hypnosis
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Dental Pain, Facial Swelling
Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth.
A randomized clinical trial will compare two root canal filling approaches in necrotic single-rooted teeth. The test group will receive bioceramic mono-block obturation using bioceramic nano-coated gutta-percha with a bioceramic…
- Trial name
- NCT07600099
- Testing
- Resin sealer with conventional gutta percha., Bioceramic sealer with bioceramic gutta-percha.
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Perturbation Based Balance Training Versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis
This is an RCT aims to explore Perturbation-Based Balance Training versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis.
- Trial name
- NCT07653841
- Testing
- Perturbation-Based Balance Training, Progressive Neuromuscular Training
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Ibadat International University, Islamabad
Opioid Consumption, Postoperative, Multimodal Analgesia
Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery
Urologic surgery has advanced with new technologies to allow less invasive management of common afflictions such as kidney stones, these procedures are notoriously painful as the ureter must be dilated to accommodate any…
- Conditions
- Opioid Consumption, Postoperative, Multimodal Analgesia, Ureteroscopy, Ureteral Stents
- Trial name
- NCT07654296
- Testing
- multimodal analgesia regimen without suzetrigine, Suzetrigine
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Vasoconstriction, Biomarkers
Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline Placement
Medical and technological advancements allow increasingly complex invasive procedures to be performed on hospitalized patients, improving their survival rates and prognosis.
- Conditions
- Vasoconstriction, Biomarkers, Central Venous Catheters, Midline Catheter
- Trial name
- PICC (NCT07696156)
- Testing
- Immersive Virtual Reality, Peripherally Inserted Central Catheter (PICC), Mepivacaine 2% Injection
- Where
- 4 sites in Spain
- Volunteers
- 202 people
- Sponsor
- diana garcia
Oocyte Retrieival and Post Operative Pain Control, Acupuncture
ACU-TENS on Pain and Stress Reduction Before and During TUGOR
Objectives: To demonstrate the use of acupuncture-type transcutaneous electrical nerve stimulation (acu-TENS) during transvaginal ultrasound-guided oocyte retrieval (TUGOR) will reduce 50% of the intensity of pain experienced by…
- Trial name
- NCT06910540
- Testing
- Acu-TENS
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Chinese University of Hong Kong
Limb Injury
Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine
The purpose of this study is to determine if IN fentanyl (1.5 µg/kg) or IN ketamine (1 mg/kg) is more effective at 30 minutes than oral morphine (0.5 mg/kg) in reduction of moderate and severe pain associated with limb injuries…
- Trial name
- ANTAMIN (NCT06464146)
- Testing
- Morphine, IN fentanyl, IN ketamine
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgical Blood Loss, Postoperative Pain
PVI vs ESP Block for Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery.
This randomized controlled trial compares periarticular vasoconstrictor infiltration (PVI) versus erector spinae plane block (ESP) to reduce bleeding and postoperative pain in adults undergoing lumbar fusion surgery (up to 3…
- Conditions
- Surgical Blood Loss, Postoperative Pain, Lumbar Spinal Fusion Surgery
- Trial name
- NCT07550114
- Testing
- Periarticular vasoconstrictor infiltration (PVI), Erector Spinae Block (ESP)
- Where
- 2 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Labor Pain and to Reduce Pain
Can Labor Pain be Reduced by Open Placebo Intervention? A Bayesian Account for Labor Pain
The human nervous system continuously processes a potentially overwhelming stream of signals from bodily senses, which induces uncertainty.
- Trial name
- NCT07077590
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Roi Treister
Elective Heart Surgery
Ear Acupressure for Reducing Anxiety and Pain During Heart Surgery
Acupuncture and acupressure, rooted in Traditional Chinese Medicine, are used to treat a variety of symptoms. One specific and easy-to-apply method is ear acupuncture/acupressure following the NADA protocol (developed by the…
- Trial name
- NCT07010003
- Testing
- Acupressure
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University Hospital Tuebingen
Pain Management, Fear
Distraction Methods for Reducing Pain and Fear During Blood Draw in Children
Blood draw is a common invasive procedure that can cause pain and fear in children. This randomized controlled trial aims to compare the effects of pinwheel blowing, 3D hologram viewing, and sugar-free gum chewing on pain and…
- Trial name
- PED-DISTRACT (NCT07770191)
- Testing
- 3D Hologram Viewing, Pinwheel Blowing, Gum Chewing
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Gülsev Kutman
Pain, Acute
The Efficacy of Acu-TENS as an Adjunct Analgesic During USG-MVA
Objectives: To prospectively evaluate the potential of acu-TENS to reduce the pain experienced by women undergoing ultrasound-guided manual vacuum aspiration (USG-MVA) and evaluate its safety profile.
- Trial name
- NCT06411054
- Testing
- Acu-TENS
- Where
- Hong Kong
- Volunteers
- 108 people
- Sponsor
- Chinese University of Hong Kong
Postoperative Pain
RCT to Test Regional Anesthesia Effect on Decreased Opiate Use
Examining use of strong pain medication with the use of perioperative anesthetic medications vs no use of the same perioperative medication
- Trial name
- NCT06989866
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Procedural Pain During Endotracheal Suctioning
Effects of Family-Proxy-Selected Natural Sound Therapy Versus Standardized Natural Sound and Noise Reduction on Procedural Pain During Endotracheal Suctioning in Non-Communicative Mechanically Ventilated Adults: A Four-Arm Randomized Controlled Trial
Endotracheal suctioning is a common procedure used to remove secretions from the airways of patients receiving mechanical ventilation. Although this procedure is necessary for respiratory care, it may cause pain and discomfort.
- Trial name
- FPSNST (NCT07920029)
- Testing
- Family-Proxy-Selected Natural Sound Therapy, Standardized Natural Sound Therapy, Environmental Noise Reduction During Endotracheal Suctioning
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- University of Basrah
Knee Arthritis
Cannabidiol (CBD) in Pain Reduction for Knee Osteoarthritis
The purpose of this study is to see if cannabidiol (CBD) orally dissolving tablets (ODTs) can lessen pain, improve function, and improve patient satisfaction in cases of knee osteoarthritis.
- Trial name
- NCT05020028
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Retinal Disease
Safety and Tolerability of IRX-101 in Patients Receiving Intravitreal Injections
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- COMFORT (NCT05750589)
- Testing
- IRX-101, Providone-Iodine
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Healthy, Behavior Management
Effect of Vibrasthetic Device on Pain Reduction During Local Anesthesia in Pediatric Patients
The goal of this clinical trial is to test if children aged between 6 and 14 years who are receiving a dental injection will feel less pain by using a vibration device applied to the injection site during the injection compared…
- Trial name
- NCT07306650
- Testing
- Vibrating device, Manual vibration
- Where
- Saudi Arabia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Intrauterine Device
MUSIC Prior to a T380A Intrauterine Device Insertion in Nulliparous Women.
The aim is to evaluate the role of music in reducing pain and anxiety during copper IUD insertion in nulliparous women
- Trial name
- NCT06783920
- Testing
- music, no music
- Volunteers
- 100 people
- Sponsor
- Cairo University
Peripheral Intravenous Cannulation, Pain Management
Is Pain Ease (New Formula) Safe and Effective in Reducing Pain Associated With Peripheral Intravenous Cannulation (PIV)?
The goal of this clinical trial is to learn if Pain Ease (new formula) is more effective than Nature's Tears in reducing pain associated with Peripheral Intravenous Cannulation (PIV), also known as an IV.
- Trial name
- NCT07821476
- Testing
- Sterile water, Vapocoolant spray
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gebauer Company
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty
The goal of this clinical trial is to learn if the NEUROCUPLE device can reduce pain and opioid use after primary unilateral total knee arthroplasty (TKA) in adults.
- Trial name
- NCT07439666
- Testing
- NEUROCUPLE™ Patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 274 people
- Sponsor
- Jacques E. Chelly