Clinical trials: Pain Response
Insomnia
Preventing the Inflammatory Response to Experimentally-induced Insomnia Symptoms
The main purpose of this study is to learn about the effects of sleep disruption (two days in a row where sleep is shortened and disrupted) on inflammation, mood (how you feel), and pain processing (your own…
- Trial name
- NCT02268565
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pain
Brain Response to Pain Control in People With Chronic Pain
Background: Researchers want to look at how the brain responds to painful stimulations. They also want to see if these responses are different in people with and without chronic pain.
- Trial name
- NCT01878019
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Acute Pain, Postoperative Pain
Study of QL Analgesic Response and Extent
A total of 14-18 healthy volunteers will be included. There will be three different procedure days, separated by at least one week. On each visit, the subjects will receive a QL block, according to the randomization process.
- Conditions
- Acute Pain, Postoperative Pain, Regional Anesthesia Block
- Trial name
- SQUARE (NCT07566312)
- Testing
- Quadratus Lumborum with 1.5% Lidocaine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Suicide
Burden, Belonging, and Response to Pain in Veterans
The primary purpose of the current study is to rigorously test the psychometric properties of the INQ-12 and ACSS (Van Orden et al., 2008) in Veterans, something which has not been done to date.
- Trial name
- NCT01507675
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Perioperative Inflammatory Response, Postoperative Pain
Suprazygomatic Maxillary Nerve Block Effect on Systemic Inflammatory Response in Cleft Palate Surgeries
the aim is to determine the value of adding bilateral supra zygomatic maxillary nerve block to general anesthesia in attenuating the systemic inflammatory response in paediatrics.
- Trial name
- NCT05495750
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alaa Mohamed Abdel Salam Ibrahim Soliman
Dental Anxiety, Hemodynamic
Anxiety and Hemodynamic Changes in Third Molar Extraction After Patient Education
This randomized clinical trial investigates the effect of different preoperative patient information strategies on anxiety levels and hemodynamic responses during third molar extraction.
- Conditions
- Dental Anxiety, Hemodynamic, Molar, Third, Tooth Extraction
- Trial name
- NCT07018115
- Testing
- Basic Preoperative Information, Detailed Verbal Preoperative Information, Visual Preoperative Information (2D Animation)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Ummugulsum Coskun
Chronic Low Back Pain (CLBP)
Neuroimmune Responses to Exercise in Chronic Back Pain
The goal of this mechanistic clinical trial is to learn how physical exercise affects the body and brain in people with chronic low back pain.
- Trial name
- eCLBP (NCT07497425)
- Testing
- Physical Exercise
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McGill University
Pro-inflammatory Activity, Immunologic Activity Alteration
Pain, Opioids and Pro-Inflammatory Immune Responses
Providing pain management to the patient who abuses prescription opioids presents a clinical challenge, not only due to concerns about "drug-seeking", but because they have increased sensitivity to pain, a phenomenon identified…
- Trial name
- NCT01210066
- Testing
- Fentanyl, Cold pressor test, Fentanyl plus cold pressor test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy, Acute Pain
Detection of Electrodermal Activity in Pain 1
The goal of this study is to investigate the association between self-reported pain and electrodermal activity and to develop an algorithm that detects pain-related changes in electrodermal activity in healthy volunteers…
- Trial name
- DEEP 1 (NCT06678217)
- Testing
- Stroop task, Cold pressor test
- Where
- Denmark
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Jet Injection, Local Anasthesia
This Study Evaluate the Patient Response to Jet Injection, Pain and Satisfaction Compared to Conventional Method of Local Anasthesia Especially in Maxillary Teeth
Pain during administration of local anesthesia remains one of the major concerns in dental practice, often leading to anxiety and treatment avoidance.
- Trial name
- NCT07581249
- Testing
- Non aspirating dental syringe, The use of jet injection
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Pain Sensation, Hyperalgesia
Pain Response to Cannabidiol in Induced Acute Nociceptive Pain, Allodynia and Hyperalgesia By Using a Model Mimicking Acute Pain in Healthy Adults
This study is to investigate the effect of CBD on acute pain in healthy volunteers in a well-established acute pain model.
- Conditions
- Pain Sensation, Hyperalgesia, Allodynia
- Trial name
- CANAB I (NCT03985995)
- Testing
- CBD 800 mg p.o
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Post Operative Pain, Erector Spinae Plane Block
The Effect of Local Anesthetic Infiltration or Erector Spina Plan Block on Stress Hormone Response
Laparoscopic cholecystectomy is one of the most common operations in abdominal surgery. Effective analgesia in the postoperative period; It is of great importance in terms of acceleration of recovery, prevention of atelectasis…
- Conditions
- Post Operative Pain, Erector Spinae Plane Block, Inguinal Hernia
- Trial name
- NCT05717530
- Testing
- wound site local anesthesic infiltration, Erector spina plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Low Back Pain
Predicting Patients' Response to Spinal Manipulation
The purpose of this study is to compare the clinical effectiveness of two types of chiropractic spinal manipulation to conservative medical care for patients at least 55 years old with sub-acute or chronic LBP.
- Trial name
- NCT00285649
- Testing
- HVLA-SM, LVVA-SM, Usual Medical Care
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Palmer College of Chiropractic
Vagus Nerve Autonomic Disorder, Heart Rate
Balance, Autonomic Response, and Sensory Modulation to Dosage of Mechanical Vagal Stimulation in Healthy Adults
The vagus nerve (VN) plays a crucial role in regulating vital functions (heart rate, blood pressure, digestion, and immune response) and maintaining communication between internal organs and the brain.
- Conditions
- Vagus Nerve Autonomic Disorder, Heart Rate, Pain, Equilibrium; Disorder, Labyrinth
- Trial name
- BARVANS (NCT06541808)
- Testing
- mechanical Vagus Nerve Stimulation (Low Intensity), mechanical Vagus Nerve Stimulation (Intermediate Intensity), mechanical Vagus Nerve Stimulation (High Intensity)
- Where
- Austria
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Pain
Brainwave Activity Response on Common Physical Therapy Intervention
This study is designed to evaluate the if there is a predictable patterns in brainwave activity and to see how this changes with external physical therapy interventions such as manipulation, soft tissue massage, and exercise.
- Trial name
- NCT04542707
- Testing
- joint manipulation, Exercise, Soft tissue massage
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Florida Gulf Coast University
Pain
Breast Feeding Analgesia in Preterm Infants
The purpose of this study is to compare the effects of mothers' breastfeeding with the effects of pacifier sucking on preterm infant biobehavioural responses during and immediately after a painful procedure Hypothesis: 1.
- Trial name
- NCT00175409
- Testing
- Blood collection
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Tooth, Impacted, Trismus
Efficacy of Chronoterapy in Oral Surgery
Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus.
- Conditions
- Tooth, Impacted, Trismus, Pain, Inflammatory Response
- Trial name
- ECOS (NCT05126264)
- Testing
- Ibuprofen 400 mg
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid