Clinical trials: Pain Severity
Light Sensitivity
"Eye Protection After Mydriatic Use for ROP Screening: Impact on Vitals Signs and Pain Scores"
Pupillary dilation induced by mydriatic agents during Retinopathy of Prematurity exams can persist for hours. Despite regular use of eye protection for mydriatic-induced light sensitivity for infants, children and adults, eye…
- Trial name
- NCT01860534
- Testing
- eye covers
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Thalassemia
Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood Transfusions
Thalassemia is an inherited blood disorder that can result in mild to severe anemia. Regular blood transfusions, which refresh the healthy red blood cell supply, are one treatment for thalassemia.
- Trial name
- NCT00872833
- Where
- 9 sites in United States, Canada
- Volunteers
- 32 people
- Sponsor
- Carelon Research
Abortion Second Trimester
Overnight Pain Treatment Investigating Opioids vs. Nonopioids
The purpose of this study is to compare maximum pain scores between patients seeking induced abortion and requiring cervical preparation with osmotic dilators.
- Trial name
- OPTION (NCT03545893)
- Testing
- Ibuprofen 600 mg, OxyCODONE 5 Mg Oral Tablet
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pennsylvania
Pain
Pain Perception With Tenaculum Placement
Randomized controlled trial that compares methods of tenaculum placement during intrauterine device insertion and their effect on pain.
- Trial name
- NCT02969421
- Testing
- Cough method for placement of tenaculum, Slow Tenaculum Placement of tenaculum
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Postoperative
Thoracic Paravertebral Block Using Ropivacaine and Dexmedetomidine
The hypothesis of the study is whether dexmedetomidine plus local anesthetic ropivacaine could extend the pain relieve time compared with only ropivacaine when thoracic paravertebral block is performed at the end of…
- Trial name
- NCT02814890
- Testing
- Video-assisted Pneumonectomy, Thoracic paravertebral block
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Jianghui Xu
Back Pain
The Effect of PTH(1-84) or Alendronate on Reduction of Back Pain in Postmenopausal Women With an Osteoporosis Related Vertebral Fracture(s) (FP-005-IM)
The primary objective of this trial is to show that PTH(1-84) is superior to alendronate in reducing back pain intensity over a 24-week treatment period in postmenopausal women with an osteoporosis related vertebral fracture(s).
- Trial name
- NCT00713258
- Testing
- Parathyroid hormone (PTH) (1-84), Alendronate
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Nycomed
Postoperative Pain
The Transversus Abdominis Plane Block: A Prospective Randomized Clinical Trial Using EXPAREL.
The purpose of the study is to evaluate the effectiveness of EXPAREL in a transversus abdominis plane block by assessing the demand of postoperative narcotic, length of hospital stay and incidence of postoperative complications.
- Trial name
- NCT02263963
- Testing
- Exparel, TAP Block
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Corewell Health West
Low Back Pain
EMG Activation of Gluteal Musculature During Exercises With and Without Resistance
The gluteus medius (Gmed) and gluteus maximus (Gmax) muscles are important components in the treatment of many lower limb injuries.
- Trial name
- GlutEMG02 (NCT01841216)
- Testing
- Lower Body Exercises with and without resistance
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sport and Spine Rehab Clinical Research Foundation
Pain, Low Back Pain
An Efficacy and Safety Study for Tapentadol Extended Release (JNS024ER) in Chronic Pain Participants
The purpose of this study is to evaluate the efficacy, safety and to explore the pharmacokinetics (how drugs are absorbed in the body, how they are distributed within the body and how they are removed from the body over time) of…
- Conditions
- Pain, Low Back Pain, Back Pain, Osteoarthritis, Knee
- Trial name
- NCT01124604
- Testing
- Tapentadol Hydrochloride
- Where
- 19 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Janssen Pharmaceutical K.K.
Acute Pain
Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction
This study aims to evaluate the analgesic efficacy of single and multiple doses of a new fixed dose combination of nefopam hydrochloride 30 mg and paracetamol 500mg taken orally in comparison to each single component.
- Trial name
- NCT04622735
- Testing
- nefopam hydrochloride 30mg / paracetamol 500mg X2, Paracetamol 500 Mg Oral Tablet X2, Nefopam HCl 30 MG Oral Tablet X2
- Where
- 19 sites in Belgium, France and 3 more
- Volunteers
- 321 people
- Sponsor
- Unither Pharmaceuticals, France
Pain, Chronic
Mobile-Based Contingency Management to Promote Daily Self-monitoring in Primary Care Patients
This project examines the efficacy and feasibility of contingency management (CM), delivered using a novel, fully automated CM app (DynamiCare Rewards), to promote daily self-monitoring of pain symptom severity and related…
- Trial name
- ProMPT (NCT03962491)
- Testing
- Daily Self-Monitoring Surveys + Contingency Management, Daily Self-Monitoring Surveys
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Virginia Commonwealth University
Tissue Pain
Optical Measurements of the Skin Surface to Infer Distinctions in Myofascial Tissue Stiffness
This study involves imaging the skin movements of surface tissue on the back. A clinician will perform assessment and intervention procedures manually, using manual and light movements of stretch and compression.
- Trial name
- OptMeasSkin (NCT06390085)
- Testing
- Soft tissue manipulation
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Postoperative Pain
Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients
The United States constitutes <5% of the world's population but over 80% of the opioid supply and 99% of the hydrocodone supply.
- Trial name
- NCT03236155
- Testing
- opioid pain pills
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Acute Low Back Pain
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
Low back pain causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In a general low back pain (LBP) population, prognosis is poor.
- Trial name
- NCT01587274
- Testing
- Naproxen, Cyclobenzaprine, Oxycodone/ acetaminophen
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Montefiore Medical Center
Pain
Superiority Study for Pain Treatment After Cesarean
The purpose of this study is to investigate adequate pain treatment for patients after cesarean. In this study oral opioids were compared to intravenous opioids as they are supposed to provide superior pain control.
- Trial name
- NCT01115101
- Testing
- Oral Oxycodon, Piritramid
- Where
- Germany
- Volunteers
- 239 people
- Sponsor
- Max Dieterich
Postoperative Pain
Efficacy of Intrathecal Oxytocin to Speed Recovery After Hip Surgery
The purpose of this study is to determine the effect of intrathecal oxytocin on speed of reduction in pain for the first 60 days after hip surgery.
- Trial name
- NCT03011307
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Wake Forest University Health Sciences
Pregnancy, Pain
VerTouch Device: A Prospective Randomized Controlled Trial
This study will compare the VerTouch device to palpation and ultrasound (US) techniques used to identifying the anatomic landmarks and optimal location for neuraxial access.
- Trial name
- NCT04630171
- Testing
- Group #1: VerTouch utilized for identification of site for labor epidural or spinal anesthesia procedure, Group #2: Ultrasound (US) utilized for identification of site for labor epidural or spinal anesthesia procedure, Group #3: Control group, palpation utilized for identification of site for labor epidural or spinal anesthesia procedure
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Northwestern University
Effect of Drug
Efficacy of Trypsin-Chymotrypsin On Post-operative Pain After Single Visit Root Canal Treatment
Achieving effective pain control after endodontic treatment is still a disruptive event to all the clinicians. There is a knowledge gap regarding the effect of protease on postoperative pain following root canal treatment…
- Trial name
- NCT05479747
- Testing
- post operative analgesics
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Stress, Pain
Evaluation of the Surgical Pleth Index During Spinal and General Anesthesia
The Surgical Pleth index (SPI) has been introduced as a non invasive tool to "measure" stress and pain during surgery. Preliminary studies were performed in patients under general anaesthesia with propofol and remifentanil.
- Trial name
- NCT00789438
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University Hospital Schleswig-Holstein
Headache, Post-Concussion Syndrome
The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Pilot study looking at the Osteopathic Manipulative Treatment (OMT) for various headache types in patients with post-concussion syndrome (PCS).
- Trial name
- NCT04732338
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hackensack Meridian Health