Clinical trials: Pain Severity
Pregnancy
Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
The purpose of this study is to determine what dose of medication administered through a combined spinal epidural (CSE) provides the optimal pain relief with the minimal amount of side effects.
- Trial name
- NCT02159807
- Testing
- Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Interstitial Cystitis, Bladder Pain Syndrome
Transvaginal Botulinum Toxin A for Interstitial Cystitis / Bladder Pain Syndrome
Interstitial cystitis / bladder pain syndrome (IC/BPS) is a debilitating condition that affects millions of women in the United States.
- Trial name
- T3STOPBPS (NCT05485207)
- Testing
- Transvaginal botulinum toxin A (BTA) injection
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Chronic Pain
Development of a Medical Device Utilizing an EEG-Based Algorithm for the Objective Quantification of Pain
Obtained 19 lead EEG data from 50 chronic pain patients along with their clinical history and self-reported pain scored. Machine learning was used to analyze the EEG data and derive a chronic pain biomarker.
- Trial name
- NCT03998007
- Testing
- IRIS System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- PainQx, Inc
Acute Pain
Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy
The primary objective is to evaluate the analgesic efficacy of intravenous (IV) oliceridine administered as needed (PRN) compared with placebo in patients with moderate to severe acute postoperative pain after bunionectomy.
- Trial name
- APOLLO-1 (NCT02815709)
- Testing
- Oliceridine, Morphine
- Where
- 7 sites in United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Trevena Inc.
Osteoarthritis of the Knee
Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement
The purpose of this study is to test whether surgical insertion of total knee replacement provides further improvement in quality of life, pain and function in addition to an algorithm for systematic non-surgical treatment…
- Trial name
- MEDIC (NCT01410409)
- Testing
- Neuromuscular training (NEMEX-TJR), Paracetamol, Burana
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Pain, Oral Surgery
Hyaluronic Acid and Amino Acid Gel Applied to the Alveolar Socket After Mandibular Third Molar Extraction
Objective: The study aimed to assess the effect of topical application of an amino acid + sodium hyaluronate acid gel after lower third molar extraction.
- Conditions
- Pain, Oral Surgery, Third Molar Extraction
- Trial name
- NCT03428698
- Testing
- Aminogam
- Where
- Italy
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Padova, School of Dental Medicine
Post Operative Pain, Chronic Pain
Performance and Safety of the ANTALGEEK® Thess Monitoring Medical Device in the Outpatient Management of Acute Pain and Postoperative Recovery
Acute postoperative pain (APOP) is a major public health problem, affecting nearly 10 million patients in France each year. Effective analgesic therapy in the first postoperative week is a key factor in reducing early…
- Trial name
- TRACE (NCT07680998)
- Testing
- Post-operative follow-up using the Thess Telemonitoring device in conjunction with the ANTALGEEK® protocol
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pain, Anxiety
Comparison of Different Methods for Reducing Pain From Influenza Vaccine Injections
The purpose of this study is to compare four different analgesic strategies in adults undergoing routine influenza immunization
- Trial name
- NCT01006187
- Testing
- Liposomal lidocaine, Vapocoolant spray, Rubbing adjacent to the injection site
- Where
- Canada
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Pelvic Girdle Pain, Biomechanical and Viscoelastic Properties of Plantar Fascia
Biomechanical and Viscoelastic Properties of Plantar Fascia in Pregnant Women
Pelvic girdle pain is frequently experienced in pregnant women and the mechanism of pelvic girdle pain is not known exactly. The aim of this study is to investigate the effect of biomechanical and viscoelastic properties of…
- Conditions
- Pelvic Girdle Pain, Biomechanical and Viscoelastic Properties of Plantar Fascia, Pregnant Woman
- Trial name
- NCT04620993
- Testing
- Evaluation of biomechanics and viscoelastic properties of plantar fascia, Evaluation of navıcular drop, Evaluation of plantar pressure distrubution
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pain
Auranofin in Decreasing Pain in Patients With Paclitaxel-Induced Pain Syndrome
This randomized pilot clinical trial studies whether auranofin will relieve pain following paclitaxel in patients who have previously experienced paclitaxel-induced pain.
- Trial name
- NCT02063698
- Testing
- auranofin, questionnaire administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Prostate Cancer
ZD4054 (Zibotentan) in Pain-free or Mildly Symptomatic Patients With Prostate Cancer and Bone Metastases Who Have Rising Serum Prostate Specific Antigen (PSA)
This study is being carried out to see if ZD4054 (Zibotentan) is effective in treating prostate cancer and spread of cancer to the bone, and if so, how it compares with placebo (sugar pill).
- Trial name
- NCT00090363
- Testing
- ZD4054 15 mg, ZD4054 10 mg
- Where
- 60 sites in United States, Australia and 12 more
- Volunteers
- 447 people
- Sponsor
- AstraZeneca
Fabry Disease, Neuropathic Pain
Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
The purpose of this study is to determine efficacy of gabapentin vs. placebo at controlling peripheral neuropathic pain in patients with Fabry disease, and reducing their use of opioid analgesics.
- Trial name
- NCT01588314
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- University of Minnesota
Lumbosacral Radiculopathy
Effects of Multimodal Physical Therapy in Patients With Lumbosacral Radiculopathy
Purposes of the study To investigate the effect of Multimodal Physical Therapy on pain, daiablility H-reflex, and Diffusion Tensor Imaging (DTI) Parameters in Patients With Lumbosacral Radiculopathy.
- Trial name
- NCT06058806
- Testing
- Multimodal Physical Therapy
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Cairo University
Phantom Limb Pain
Incidence of Phantom Limb Pain and Method of Anesthesia After Lower Extremity Amputation
Phantom limb pain (pain originating from where an amputated limb once was) is a common occurrence after lower extremity amputations, with some sources noting incidence to be as high as 60-80% six months after surgery.
- Trial name
- NCT01003704
- Testing
- Lower extremity amputation
- Where
- United States
- Sponsor
- North Texas Veterans Healthcare System
Chronic Low Back Pain (CLBP)
A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pain
This study is a prospective, multi-center study designed to compare the safety and efficacy of spinal cord induced muscle stimulation (MuscleSCS) for the treatment of chronic low back pain.
- Trial name
- MuscleSCS (NCT07215104)
- Testing
- MuscleSCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saint Francis Hospital
Pain, Postoperative
Prediction of Pain in Total Knee Arthroplasty
In this consecutive, prospective cohort study trial the investigators evaluate if preoperative pain response upon heat stimulation is predictive for acute and subacute postoperative pain after total knee arthroplasty.
- Trial name
- NCT01179204
- Testing
- Preoperative heat stimulation
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Hvidovre University Hospital
Perioperative Period
The Effect of Listening To Music And Foot Reflexology in Children During Perioperative Period
The population of the research will be children between the ages of 7 and 12 who underwent day surgery at the Pediatric Surgery Clinic of the Gynecology and Childhood Hospital of Ordu University Training and Research Hospital.
- Trial name
- NCT05655884
- Testing
- Music Listening Application, Foot Reflexology Practice:
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people
- Sponsor
- Ordu University
Post-thoracotomy Shoulder Pain
A Study of the Incidence of Post-Thoracotomy Shoulder Pain
Patients undergoing chest surgery (thoracotomy) often develop shoulder pain after their operation despite epidural pain control of the incision.
- Trial name
- NCT00373984
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Rotator Cuff-related Shoulder Pain, Augmented Feedback
Effects of Knowledge of Results Intervention in Rotator Cuff-Related Shoulder Pain
Previous research demonstrates that augmented feedback effectively enhances motor skills and performance in both healthy individuals and those with neurological conditions.
- Conditions
- Rotator Cuff-related Shoulder Pain, Augmented Feedback, Rehabilitation
- Trial name
- NCT07632729
- Testing
- Knowledge of Results, Standart Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Elif Turgut
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080 How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given to Participants With Moderate Renal Impairment and End Stage Renal Disease Requiring Dialysis Compared With Matched Participants With Normal Renal Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04471337
- Testing
- BAY1817080
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
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