Clinical trials: Pain Tolerance
Pain
Mechanistic Study of Duloxetine in Breast Cancer Patients With Chronic Pain
Early stage breast cancer is typically treated with surgery, chemotherapy, radiation therapy, and/or endocrine therapy. Following treatment, 25-60% of breast cancer survivors have reported chronic pain, which can be difficult to…
- Trial name
- NCT01912612
- Testing
- Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan Rogel Cancer Center
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Pain Threshold, Stretching
The Effect of Stretching Intensity on Pain Sensitivity
The primary objective of this study is to determine the immediate efficiency of stretching intensity on regional and distant pain sensitivity in healthy subjects.
- Conditions
- Pain Threshold, Stretching, Pain Sensitivity, Range of Motion
- Trial name
- NCT05989490
- Testing
- Static stretching
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Sleep Apnea, Chronic Pain Syndrome
Sleep and Pain Sensitivity
This project will assess patients with diagnosed obstructive sleep apnea, to investigate the impact of poor sleep on central pain mechanisms.
- Trial name
- NCT04246294
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Aalborg University
Cervical Radiculopathy
Effect of Manual Therapy on Sensory Features in Patients With Cervical Radiculopathy
Background \& Purpose: Cervical radiculopathy is a neurological disorder, which commonly results because of nerve compression. There are different types of physical therapy interventions that are used for cervical radiculopathy.
- Trial name
- NCT03328351
- Testing
- manual therapy, Superficial soft tissue massage
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 28 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Plantar Fasciitis, Chronic, Tibial Nerve
Tibial Nerve Size and Clinical Features in Chronic Plantar Fasciitis
This cross-sectional observational study aims to examine the relationship between tibial nerve cross-sectional area at the tarsal tunnel and plantar fascia thickness, pressure pain threshold, foot posture, and functional status…
- Trial name
- NCT07878273
- Testing
- Pressure Pain Threshold Assessment, Plantar fascia ultrasonographic Assessment, Tibial nerve ultrasonographic assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Patients With Trigger Finger
The Effect of Cassava Waxes Hot Bath on Pain, Pressure Pain Threshold and Hand Function Among Patients With Trigger Finger
Objective: This study aimed to evaluate the efficacy of cassava wax hand immersion combined with ultrasound therapy on pain severity, pain threshold, finger locking frequency, and hand functional ability in patients with trigger…
- Trial name
- NCT07128043
- Testing
- ultrasound therapy and cassava wax hot immersion, ultrasound therapy
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- University of Phayao
Osteoarthritis
A Single Center 2-way Crossover Study to Investigate the Mechanism of Action of Etoricoxib in Subjects With Osteoarthritis Knee Pain
The purpose of this study is to investigate which pain mechanisms that can be affected by etoricoxib compared to placebo (inactive medication)in subjects with painful knee osteoarthritis af 4 weeks of treatment.
- Trial name
- NCT01619150
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- C4Pain
Breast Cancer
Interest of Self-compression Technique on Tolerance of Mammography
Mammography is used for screening, diagnosis, therapeutic evaluation and monitoring of local cancer breast. It is sometimes poorly tolerated by some patients who complain of an uncomfortable examination or pain.
- Trial name
- ITACTs (NCT02866591)
- Testing
- mammography according to an auto-compression procedure, mammography according to a standard procedure, questionary
- Where
- 6 sites in France
- Volunteers
- 550 people
- Sponsor
- Institut de Cancérologie de Lorraine
Knee Osteoarthritis
End-range Mobilization on Time Curve of Pressure Pain Threshold
Pain in knee osteoarthritis (OA) represents increased pain intensity due to peripheral and central sensitivity. Pressure pain threshold (PPT) is a widely applied technique for measuring the magnitude of peripheral and central…
- Trial name
- NCT04629625
- Testing
- End-range mobilization, Non end-range mobilization
- Where
- 2 sites in Hungary
- Volunteers
- 66 people
- Sponsor
- University of Pecs
Neck Pain
Influence of Adding High Power Pain Threshold Ultrasound to Traditional Therapy on Axioappendicular Muscles Amplitude and Fatigue in Mechanical Neck Pain Randomized Clinical Trials
The purpose of this study will investigate the effect of adding high power pain threshold ultrasound to traditional therapy on axioappendicular muscles amplitude and fatigue in neck pain
- Trial name
- MNP (NCT05540093)
- Testing
- high power pain threshold ultrasound, traditional therapy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Whiplash, Whiplash Injury
Changes of Pain Sensitivity During Rehabilitation of Patients Suffering From Whiplash Associated Disorders
This study investigates the sensory profile of people suffering from whiplash associated disorders (WAD) during rehabilitation.
- Conditions
- Whiplash, Whiplash Injury, Neck Pain, Healthy
- Trial name
- NCT03784196
- Testing
- Conservative rehabilitation
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Covid19
Self- Versus Conventional-swabbing for COVID-19 Screening (COVISWAB)
Self-swabbing requires less personal protective equipment and could allow to test more people and even to do quick self-diagnosis if antigenic tests are available.
- Trial name
- COVISWAB (NCT04831853)
- Testing
- nasopharyngeal swabbing procedure (self swabbing first), nasopharyngeal swabbing procedure (conventionnal swabbing first)
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Cervicogenic Headache
The Effect of Myofascial Release in Patients With Cervicogenic Headache
Cervicogenic headache (CeH) is a secondary and often unilateral that is known by referring pain from soft or hard cervical structures to occipital, temporal, frontal and sometimes pre-orbital regions.
- Trial name
- RCT (NCT03113357)
- Testing
- Myofascial release technique, conventional exercise therapy
- Where
- Iran
- Volunteers
- 34 people
- Sponsor
- University of Social Welfare and Rehabilitation Science
Low Back Pain
Clinical and Neuromechanical Predictors for the Evolution of Chronic Non-specific Low Back Pain
The purpose of the present study is to determine the association between factors known to be associated with the development of chronic low back pain (psychological and biological) and the evolution of functional disability in…
- Trial name
- NCT02373345
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Université du Québec à Trois-Rivières
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Healthy
A Phase 1 Study of FZ008-145 in Healthy Subjects.
The study will be conducted in 5 parts: Part A and Part B (single ascending dose [SAD] in solution formulation and tablet respectively), Part D and Part D2 (cold pressor test [CPT] to evaluate pain tolerance following single…
- Trial name
- NCT06685809
- Testing
- FZ008-145 solution, FZ008-145 Tablet
- Where
- Australia
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Guangzhou Fermion Technology Co., LTD
Trigger Points
Effect of Thoracic Manipulation on Latent Trigger Point
The aim of this study is to investigate the effect of one session thoracic manipulation on pressure pain threshold and rhomboid muscle strength in healthy individuals with latent trigger point.
- Trial name
- NCT05554887
- Testing
- Thrust manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
SCS, Chronic Pain
Paresthesia Free Spinal Cord Stimulation (PF-SCS)
The goal is to document efficacy of PF-SCS therapy in a blinded fashion and better understand how SCS therapy works in the clinical setting.
- Trial name
- NCT03670147
- Testing
- PF-SCS programming
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Prostatic Cancer
Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy
To assess the effectiveness of two anesthetic techniques by measuring the pain through visual analog scale (VAS), to obtain saturation prostate biopsies.
- Trial name
- NCT02909049
- Testing
- MIDAZOLAM, MEPIVACAÍNE, FENTANILE
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña