Clinical trials: Pain Tolerance
Pain, Hypogonadism
Effects of Testosterone Replacement on Pain Sensitivity and Pain Perception
Naturally occurring opiates (endorphins) decrease testosterone levels by inhibiting the synthesis of gonadotropin releasing hormone (GnRH) and also inhibiting testosterone synthesis by the testes.
- Trial name
- TAP (NCT00351819)
- Testing
- AndroGel
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Boston University
Migraine Disorders, Tenderness, Muscle
Day to Day Variation of Pressure Pain Threshold and Muscle Hardness
The aim is to establish how headache and migraine can affect muscle hardness and tenderness in migraine patients
- Conditions
- Migraine Disorders, Tenderness, Muscle, Headache Disorders
- Trial name
- NCT03632928
- Testing
- Ultrasound Elastography, Pressure Pain threshold
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Danish Headache Center
Cervicogenic Headache, Chronic Neck Pain
Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls
The goal of this observational study is to compare physical findings across three adult groups. Cervicogenic headache (CGH) is a headache linked to a problem in the neck.
- Trial name
- NCT07776275
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Histamine, Cowhage
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: To investigate similarity and differences between itch and pain by comparing the effect of…
- Conditions
- Histamine, Cowhage, Sleep Fragmentation
- Trial name
- NCT06081946
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Electroencephalography, Anesthesia, General
Validity of Pain Threshold Index in Children
Comparison of total infused dose of remifentanil between pain threshold index monitoring group and control group
- Trial name
- NCT03622242
- Testing
- Pain threshold index, Wavelet index
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Seoul National University Hospital
Neck Pain
Sensory Characteristics and Psychosocial Factors Related With Non-specific Neck Musculoskeletal Pain Chronification
Chronic pain is commonly defined as any pain which lasts more than 12 weeks. Chronic non-specific neck pain (CNSNP) has no specific underlying disease causing the pain.
- Trial name
- CNSNP (NCT04330573)
- Testing
- No intervention. Observational study
- Where
- Spain
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Myocardial Infarction, Unstable Angina Pectoris
Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction
A three months, double-blind, randomised, parallel-group study evaluating the efficacy of sitagliptin (Januvia™) versus placebo on beta-cell function in patients with newly detected glucose abnormalities and acute myocardial…
- Conditions
- Myocardial Infarction, Unstable Angina Pectoris, Diabetes Mellitus, Impaired Glucose Tolerance
- Trial name
- BEGAMI (NCT00627744)
- Testing
- Sitagliptin
- Where
- 2 sites in Sweden
- Volunteers
- 85 people
- Sponsor
- Karolinska Institutet
Fibromyalgia, Pain
Catastrophizing and Virtual Reality's Impact on Pain in Patients With Fibromyalgia
This study evaluates the potential association between Virtual Reality, pain catastrophizing thoughts and pain measures in fibromyalgia.
- Trial name
- NCT04294914
- Testing
- Cold Pressor Test, Cold Pressor Test + Virtual Reality
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Healthy Volunteers, Vibration; Adverse Effect
Acute Effects of Smartphone-Delivered Local Vibration on Hand Sensorimotor Performance
This study investigates the acute effects of smartphone-delivered local vibration on hand sensorimotor performance in healthy young adults.
- Trial name
- SmartVib (NCT07521228)
- Testing
- Smartphone Local Vibration at 80 Hz, Smartphone Local Vibration at 150 Hz, Smartphone Local Vibration at 220 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Chronic Pain
Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids
Managing pain in patients who abuse prescription opioids presents many challenges, including the development of opioid-induced hyperalgesia (OIH).
- Trial name
- NCT01821430
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Georgetown University
Neck Pain
Effects of Pain, Disability and Cervicokinesthesia After Cervical Manipulation
Cervical spine manipulation has been found to be effective in patients with mechanical neck pain. Discrepancies exist on the side of manipulation and the placebo effect of this manual intervention.
- Trial name
- NCT02645630
- Testing
- Right Cervical Manipulation, Left Cervical Manipulation
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Universidad Rey Juan Carlos
Chronic Tension-Type Headache
Deep Neck Flexor Exercises Versus Myofascial Release of Suboccipital Muscles in Chronic Tension-type Headache
According to the study of the burden of diseases in 2018, tension-type headache(TTH) is the most common type of primary headache and ranks third in terms of prevalence among 328 diseases and injuries in 195 countries from 1990 to…
- Trial name
- NCT05383365
- Volunteers
- 44 people
- Sponsor
- Iran University of Medical Sciences
Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness
To Assess Signs and Symptoms in Women Affected by GSM After One Cycle of Pixel CO2-Alma Fractionated Laser
Genitourinary syndrome of menopause (GSM) occurs in approximately 50% of menopausal women but is both underrecognized and undertreated despite numerous treatment options.
- Conditions
- Genitourinary Syndrome of Menopause (GSM), Vaginal Dryness, Burning, Pain
- Trial name
- NCT05156502
- Testing
- Fractionated Laser (Pixel CO2-Alma), Fractionated Laser (Pixel CO.2-Alma)
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dr. Filippo Murina
Sensitivity
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
- Trial name
- SensoryFLO (NCT03283072)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Anomaly; Shoulder
Pain Sensitivity and Outcome in Arthroscopic Shoulder Surgery
The purpose of this study is to investigate whether there is a correlation between a patients pain sensitivity and their subsequent post-operative pain and surgical outcome in arthroscopic shoulder surgery.
- Trial name
- PSOASS (NCT01621555)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NHS Fife
Neck Pain
Body Composition and Cervical Outcomes in Non-Specific Neck Pain
Non-specific neck pain (NSNP) is a common musculoskeletal condition that significantly affects quality of life, daily activities, and work productivity.
- Trial name
- NCT07388706
- Testing
- Clinical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Osteoarthritis, Knee
The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Knee Osteoarthritis
The goal of this interventional study is to investigate the effectiveness of an acute bout of exercises on pain sensitivity and clinical pain among adults with knee osteoarthritis.
- Trial name
- NCT05605444
- Testing
- Single bout of exercise
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Taif University
Cancer, Pain
Oral Ketamine as an Adjuvant to Opioids for Pain Treatment in Cancer Patients
In the current research the investigators would like to examine the effect of a well acquainted drug, Ketamine, which is used by anesthesiologists to induce sleep in operations.
- Conditions
- Cancer, Pain, Tolerance
- Trial name
- NCT01207206
- Testing
- oral ketamine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Intraoral Pain Threshold
Relationship Between Electrical Pain Tolerance Threshold of Alveolar Ridge and Individual Attributes
This study was conducted with an aim to know how individual attributes associated to intraoral Pain Tolerance Threshold. The hypotheses were that the Pain Tolerance Threshold associated to age, sex, prosthodontic oral condition…
- Trial name
- NCT02474030
- Where
- Japan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nihon University
Breast Cancer
Short and Long Term Effects of a Physical Therapy Program After Breast Cancer Surgery
Objectives: To evaluate the pressure pain threshold, shoulder biomechanics, cardiorespiratory function and the quality of life associated with the short and long-term physical therapy rehabilitation following breast cancer…
- Trial name
- NCT04116281
- Testing
- Rehabilitation after breast cancer surgery
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidade Federal de Sao Carlos