Clinical trials: Pain-Knee
Pain
Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study in 232 adult subjects undergoing primary unilateral TKA under general or spinal anesthesia.
- Trial name
- NCT02713178
- Testing
- bupivacaine liposome injectable suspension
- Where
- 17 sites in United States, Belgium and 1 more
- Volunteers
- 232 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee
This is an open-label study assessing the effect of the administration of a single intra-articular (IA) injection of FX006 32 mg on synovial volume in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT03529942
- Testing
- FX006 32 mg
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 129 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis Knees Both
Reparel Knee Sleeve vs. TED Hose for Post-op Swelling, Pain and Range of Motion After Total Knee Replacement
This prospective study will evaluate pain, swelling, ROM as well as narcotic use in post-operative total knee arthroplasty patients using novel Non-Compressive Bioactive Garment (NCBG) versus current standard of care gradient…
- Trial name
- NCT04751942
- Testing
- Non-compressive Bioactive Garment, thrombo-embolic deterrent
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Posterior Knee Infiltration
Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty
To assess pain control after total knee replacement surgery using two different nerve block techniques. The 2 methods are: 1. Continuous femoral nerve block with ultrasound guided posterior capsular injection 2.
- Trial name
- NCT02701296
- Testing
- Ropivacaine with Epinephrine, Ropivacaine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Trinity Health Of New England
Osteoarthritis
Study of Meloxicam Capsules to Treat Osteoarthritis Pain
The purpose of this study is to determine whether Meloxicam [Test] Capsules are safe and effective for the treatment of osteoarthritis pain of the knee or hip.
- Trial name
- NCT01787188
- Testing
- Meloxicam Test Capsules
- Where
- 40 sites in United States
- Volunteers
- 403 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Osteoarthritis, Knee
Efficacy and Safety of XT-150 in Osteoarthritis of the Knee
This is a Phase 2 safety and efficacy study of XT-150 in adult participants experiencing moderate to severe pain due to osteoarthritis of the knee.
- Trial name
- NCT04124042
- Testing
- XT-150
- Where
- 6 sites in United States, Australia
- Volunteers
- 289 people
- Sponsor
- Xalud Therapeutics, Inc.
Osteoarthritis of the Knee, Type 2 Diabetes Mellitus
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
The purpose of this study was to compare the effects of FX006 and Triamcinolone Acetonide Injectable Suspension, United States Pharmacopeia (USP) (referred to as TCA IR in the protocol) on blood glucose (BG) in patients with…
- Trial name
- NCT02762370
- Testing
- FX006 32 mg, TCA IR 40 mg
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Postsurgical Pain
Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)
In the pilot (Part A) of this study, multiple doses of CA-008 (vocacapsaicin) were evaluated for safety, tolerability, and PK. Doses were then selected for the expanded part (Part B) of the study, where CA-008 was compared to…
- Trial name
- NCT04203537
- Testing
- CA-008
- Where
- 4 sites in United States
- Volunteers
- 193 people
- Sponsor
- Concentric Analgesics
Osteoarthritis, Knee
A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain
This is a randomized, double-blind, placebo-controlled, 2-injection, 52-week study to evaluate the efficacy and safety of intra-articular injections of CNTX-4975-05 in subjects with chronic, moderate-to-severe osteoarthritis knee…
- Trial name
- NCT03660943
- Testing
- CNTX-4975-05
- Where
- 30 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Knee Pain
Geniculate Artery Embolization for Treatment of Persistent Knee Pain Post Total Knee Arthroplasty
Single-arm, single-center, no sham or placebo, prospective pilot trial designed to evaluate the safety and efficacy of transcatheter arterial embolization in patients with persistent knee pain resistant to conservative management…
- Trial name
- NCT06134817
- Testing
- Embozene Color-Advanced Microspheres.
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- NYU Langone Health
Post Operative Pain
OXN PR Compared to OXY PR in Subjects With Postoperative Pain After Knee Arthroplasty
The purpose of this study is to demonstrate that treatment with OXN PR tablets is non inferior to treatment with OXY PR tablets in terms of analgesic efficacy in patients with postoperative pain after knee arthroplasty based on…
- Trial name
- OXN4505 (NCT01083485)
- Testing
- Oxycodone/Naloxone PR 20/10mg or 10/5mg tablets, Oxycodone
- Where
- Finland
- Volunteers
- 137 people
- Sponsor
- Mundipharma Oy
Injuries, Injury Arm
Virtual Reality for Pain in Acute Orthopedic Injuries
The goal of this study is to pilot test a skills-based virtual reality (VR) for acute orthopedic injury. It will measure the feasibility, signals of improvement, exploratory pain mechanisms, and user experience of an established…
- Conditions
- Injuries, Injury Arm, Injury;Sports, Injury, Knee
- Trial name
- NCT05552430
- Testing
- RelieveVRx
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Insomnia, Pain
Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation
This study aims to evaluate behavioral interventions in conjunction with medical rehabilitation to promote functional health in patients recovering from orthopedic surgery.
- Conditions
- Insomnia, Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- HH (NCT04269239)
- Testing
- Healthy Habits, Sleep Habits
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- Baylor College of Medicine
Total Knee Arthroplasty
Single Injection Adductor Canal Block vs Catheter for Total Knee Arthroplasty
This study investigates single injection adductor canal block (ACB) with or without intravenous dexamethasone and adductor canal catheter for pain management of total knee arthroplasty.
- Trial name
- NCT02798835
- Testing
- Adductor canal block, Adductor canal block with dexamethasone, Adductor canal catheter
- Volunteers
- 180 people
- Sponsor
- University of British Columbia
Osteoarthritis, Knee, Osteoarthritis, Hip
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
The primary objective of the study is to evaluate the efficacy of fasinumab compared with placebo, when administered for up to 16 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip.
- Trial name
- FACT OA1 (NCT03161093)
- Testing
- Fasinumab, Naproxen
- Where
- 139 sites in United States, Denmark and 10 more
- Volunteers
- 3,307 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthritis, Primary Total Knee Arthroplasty
Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
The purpose of this study is to learn if using an Interspace between the Popliteal Artery and Capsule of the Knee (iPACK) injection technique (also called a "nerve block") that numbs the nerves going to the back part of the knee…
- Conditions
- Knee Osteoarthritis, Primary Total Knee Arthroplasty, Physical Therapy, Pain
- Trial name
- NCT03353233
- Testing
- Ropivacaine, Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
PAIN
Postoperatory Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a worldwide realized procedure, with 600.000 surgeries performed per year in the United States, with a 673% increase estimated until 2030.
- Trial name
- PAINCONTROL (NCT01700517)
- Testing
- Spinal anesthesia, Femoral nerve block, sciatic nerves block
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Madre Teresa
Post Operative Pain
Efficacy and Safety Trial to Evaluate the Sufentanil NanoTab® PCA System/15 mcg (Zalviso™) for Post-Operative Pain in Patients After Knee or Hip Replacement Surgery
The purpose of this study is to compare the efficacy and safety of the Sufentanil NanoTab PCA System/15 mcg to the Placebo Sufentanil NanoTab PCA System for the management of acute moderate to severe post-operative pain after…
- Trial name
- NCT01660763
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- United States
- Volunteers
- 419 people
- Sponsor
- Talphera, Inc
Osteoarthritis, Hip, Osteoarthritis, Knee
A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee
The study schedule consists of a Screening Period (up to 14 days), a blinded 4- week Titration-to-Effect Period with weekly visits, a blinded 4-week Maintenance Treatment Period at the optimal dose level determined for each…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Arthritis, Joint Diseases
- Trial name
- NCT02944448
- Testing
- CR845 tablet 1 mg, CR845 tablet 2.5 mg, CR845 tablet 5 mg
- Where
- 35 sites in United States
- Volunteers
- 761 people
- Sponsor
- Cara Therapeutics, Inc.
Knee Osteoarthritis, Obesity
Development of a Mind Body Program for Obese Knee Osteoarthritis Patients With Comorbid Depression
Knee osteoarthritis (OA) is the most common joint disorder in the U.S. and a leading cause of disability. Depression and obesity are highly comorbid among knee osteoarthritis patients, and the combination of obesity and…
- Conditions
- Knee Osteoarthritis, Obesity, Depression
- Trial name
- GetHealthy-OA (NCT04334278)
- Testing
- GetHealthy-OA, Health Enhancement Program
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Kentucky