Clinical trials: Pain-related Fear
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Kinesiophobia (Fear of Movement), Rhematoid Arthritis
Kinesiophobia in Rheumatoid Arthritis: Associations With Functional Disability, Disease Activity, and Related Clinical Factors
Objectives: Impairment of physical function is a core feature of RA, particularly in patients with high disease activity where pain and inflammation directly limit movement.
- Conditions
- Kinesiophobia (Fear of Movement), Rhematoid Arthritis, Rheumatoid Arthritis (RA), Rheumatoid
- Trial name
- NCT07435272
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minia University
Anxiety
"Pain and Emotional Changes on Relationships Between Anxiety and Olfaction"
Introduction: This prospective study aimed to assess the impact of olfaction on providing positive emotional responses and reducing dental anxiety and pain.
- Trial name
- NCT06066073
- Testing
- Lavender Oil, Distal Water
- Where
- Saudi Arabia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Qassim University
Disc Herniation
Fear-Avoidance Beliefs and Physical Function in Patients With Lumbar Disc Herniation
Lumbar disc herniation is one of the most common causes of low back pain and is associated with substantial functional limitations and reduced quality of life, particularly among working-age individuals.
- Trial name
- FAB-LDH (NCT07674407)
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Istinye University
Pediatric Wounds, Procedural Pain
Virtual Reality Versus Game Card Distraction During Pediatric Wound Care
This completed randomized study compared two distraction approaches with standard care during pediatric open wound care. Ninety children aged 5-10 years were assigned to standard care alone, standard care plus distraction game…
- Conditions
- Pediatric Wounds, Procedural Pain, Procedure-Related Anxiety, Procedural Fear
- Trial name
- VR-WOUND (NCT07335666)
- Testing
- Distraction Game Cards, Virtual Reality Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Agri Ibrahim Cecen University
Pain, Fear
Venous Blood Sampling-Related Pain and Fear
This study is an experimental randomized controlled study conducted to compare the effect of balloon blowing, coughing, and ball squeezing methods applied during venous blood sampling from on pain and fear level in 7-12 year-old…
- Trial name
- NCT03720808
- Testing
- Balloon Blowing, Ball Squeezing, Coughing
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Sexual Pain Disorders
The Role of Pain-related Fear in Sexual Pain
The purpose of this study is the evaluate the extent to which an intervention aimed at reducing pain-related fear affects sexual function and pain sensitivity compared to usual care.
- Trial name
- NCT03385603
- Testing
- Dilator, Fear-Based Questionnaires
- Where
- United States
- Sponsor
- University of Florida
Exercise Training, Photobiomodulation Therapy
Effects of Different Exercise Programs Plus Photobiomodulation on Non-specific Low-back Pain.
The present project aims to examine the effects of different exercise programs (Pilates and multicomponent) combined with photobiomodulation therapy (PBMT) on pain intensity, postural balance, perceived disability, kinesiophobia…
- Conditions
- Exercise Training, Photobiomodulation Therapy, Low Back Pain
- Trial name
- NCT04887987
- Testing
- Pilates training + active PBMT, Multicomponent training + active PBMT
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade Norte do Paraná
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
Pain, Acute, Child, Only
Virtual Reality Distraction During Phlebotomy in Children
This randomized controlled study was conducted to evaluate the effect of distraction methods using virtual reality on the emotional appearance, pain, fear, and anxiety associated with the procedure during phlebotomy in children…
- Conditions
- Pain, Acute, Child, Only, Anxiety and Fear
- Trial name
- activeVR (NCT06336811)
- Testing
- passive virtual reality distraction, active virtual reality distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Concussion, Brain
The Influence of Prescribed Exercise on Pain Related Fear Following Concussion in Collegiate Athletes
The goal of this clinical trial is to compare the effects of acute aerobic exercise at two different intensities on psychological measures, symptomology, and time to symptom free in collegiate student athletes with concussion.
- Trial name
- NCT06246669
- Testing
- Treadmill Walking
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Virginia
Ureteroscopy
Effects of Virtual Reality and Stress Ball on Fear, Pain, Anxiety, and Satisfaction in Ureterorenoscopy Patients
This study aimed to determine the effects of virtual reality and stress ball interventions on procedure-related fear, anxiety, and patient satisfaction in patients undergoing ureterorenoscopy.
- Trial name
- NCT07265960
- Testing
- Virtual Reality, Stress Ball
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Complex Regional Pain Syndrome Type I
Graded Exposure (GEXP) in Vivo Versus Physiotherapy in Complex Regional Pain Syndrome Type I (CRPS-I)
Background: Research on the treatment of CRPS-I, as described in the Dutch evidence based treatment guidelines (Richtlijn Complex Regional Pain Syndrome type I, 2006), mainly showed improvement at the level of pain and coping…
- Trial name
- NCT00625976
- Testing
- Graded exposure in vivo, Physiotherapy
- Volunteers
- 46 people
- Sponsor
- Maastricht University Medical Center