Clinical trials: Painful Diabetic Neuropathy
Diabetic Neuropathy, Painful
An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain
To test the non-inferiority of duloxetine monotherapy as a treatment for the management of diabetic peripheral neuropathic pain as compared to pregabalin treatment among patients who have not had an adequate response to…
- Trial name
- NCT00385671
- Testing
- duloxetine hydrochloride, pregabalin, gabapentin
- Where
- 9 sites in United States, Germany
- Volunteers
- 407 people
- Sponsor
- Eli Lilly and Company
Diabetic Polyneuropathy, Sleep Hygiene
The Effect of Sleep Hygiene Education on Sleep Quality and Quality of Life in Patients With Painful Diabetic Polyneuropathy
This randomized controlled study was designed to the effect of sleep hygiene education on sleep quality and quality of life in patients with painful diabetic polyneuropathy The study was conducted between January 2025 and January…
- Conditions
- Diabetic Polyneuropathy, Sleep Hygiene, Pain
- Trial name
- NCT07646743
- Testing
- sleep hygiene education, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Trakya University
Diabetic Peripheral Neuropathy
Combined Effects of INF and OEP in Patients With Diabetic Peripheral Neuropathy
DPN often leads to balance issues, sensory deficits, and chronic pain, which can severely impact daily functioning and independence.
- Trial name
- NCT07274735
- Testing
- Intraneural facilitation therapy, Otago exercise program, Intraneural facilitation therapy with Otago exercise program
- Where
- Pakistan
- Volunteers
- 65 people
- Sponsor
- Riphah International University
Diabetic Foot
Sciatic Nerve Blocks With or Without Femoral Block Versus Spinal Anaesthesia in Patients Undergoing Diabetic Foot Surgery
Background: Dysautonomia refers to the abnormal function of the autonomic nervous system including sympathetic and parasympathetic nervous system. Diabetes mellitus causes secondary dysautonomias (1).
- Trial name
- NCT02727348
- Testing
- Sciatic with or without femoral block, Spinal anaesthesia
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- University of Malaya
Diabetic Neuropathy, Painful
A Study for the Treatment of Painful Diabetic Neuropathy
The purpose of the study is to determine if duloxetine can help patients with painful diabetic neuropathy.
- Trial name
- NCT00058968
- Testing
- Duloxetine hydrochloride
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- Eli Lilly and Company
Diabetic Neuropathy, Neuropathic Pain
Pain In Neuropathy Study
In the context of peripheral neuropathy, we will aim to elucidate correlates between sensory symptoms and: Sensory nerve dysfunction. Cutaneous small nerve fibre innervation density. Psychological co-morbidity.
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Chronic Pain, Carpal Tunnel Syndrome
- Trial name
- PINS (NCT02672059)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- King's College London
Painful Diabetic Neuropathy
Electromagnetic Stimulation (FREMS) in Patients With Painful Diabetic Neuropathy
We postulate that frequency-modulated electromagnetic stimulation (FREMS) may decrease pain in patients with painful diabetic neuropathy.
- Trial name
- NCT00337324
- Testing
- Frequency-modulated electromagnetic neural stimulation
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- IRCCS San Raffaele
Diabetic Neuropathy, Painful
Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy
The purposes of this study are to: 1) find out if pregabalin relieves pain in subjects with painful diabetic peripheral neuropathy; 2) find out if pregabalin is safe at a dose of 600 mg/day (taken twice a day); and 3) find out if…
- Trial name
- NCT00159679
- Testing
- Pregabalin
- Where
- 30 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Diabetic Peripheral Neuropathy (DPN)
Benfotiamine Versus Vitamin B1-6-12 for Diabetic Peripheral Neuropathy
The purpose of this clinical trial is to compare the efficacy of benfotiamine with vitamin B1-6-12 in reducing sensory neuropathy symptoms, numbness and pain in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07708233
- Testing
- Benfotiamine, Vitamin B1-6-12
- Where
- Thailand
- Volunteers
- 66 people
- Sponsor
- Thammasat University
Diabetic Peripheral Neuropathy
Laser Therapy for Diabetic Peripheral Neuropathic Pain
The proposed study is a randomized, double-blinded clinical trial to evaluate the efficacy of a course of laser therapy on peripheral neuropathic pain in persons with diabetes.
- Trial name
- NCT02328911
- Testing
- Laser treatment
- Where
- United States
- Sponsor
- University of Miami
Diabetic Peripheral Neuropathy
A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy
To evaluate the durability of efficacy and long-term safety of intramuscular administration of Engensis or Placebo that was administered in the double-blind, randomized, VMDN-003-2 Placebo-controlled Phase 3 Study.
- Trial name
- REGAiN-1B (NCT04873232)
- Testing
- Engensis
- Where
- 16 sites in United States
- Volunteers
- 106 people
- Sponsor
- Helixmith Co., Ltd.
Diabetes Mellitus, Painful Distal Symmetric Sensorimotor Polyneuropathy
Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy
The difference between active treatment and placebo in a clinical trial of an analgesic appears to depend on a variety of factors other than the actual efficacy of the drug itself, including various aspects of study design and…
- Trial name
- NCT01770964
- Testing
- Pregabalin, Training Type A, Training Type B
- Where
- 6 sites in United States
- Volunteers
- 90 people
- Sponsor
- Analgesic Solutions
Diabetic Peripheral Neuropathy, Diabetic Neuralgia
Neuragen for Peripheral Diabetic Neuropathy
The purpose of this study is to determine if the use of Neuragen (a natural health product oil rubbed into the skin) is effective at reducing pain and improving the quality of life in people with diabetic peripheral neuropathy.
- Trial name
- NCT00861952
- Testing
- Neuragen, Mineral oil
- Where
- 2 sites in Canada
- Sponsor
- The Canadian College of Naturopathic Medicine
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy
Efficacy and Feasibility of BurstDR SCS in Painful Diabetic Neuropathy
This prospective, single-arm clinical study evaluates the therapeutic efficacy and feasibility of BurstDR spinal cord stimulation (SCS) using Abbott's Proclaim XR and Eterna systems in patients with painful diabetic neuropathy…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Neuropathic Pain, Chronic Pain
- Trial name
- ABBT DPN (NCT07250828)
- Testing
- BurstDR Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TriCity Research Center
Painful Diabetic Neuropathy
Multimodal Intervention for Painful Diabetic Neuropathy: NeuOst Feasibility Trial
This is the feasibility study of a single-site parallel three-armed participant-blinded controlled randomised efficacy trial of a 5-week course of the 'NeuOst treatment', compared to a designated control intervention, and to…
- Trial name
- NeuOst (NCT06423391)
- Testing
- NeuOst, Control Intervention, Usual Care
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University College of Osteopathy
Diabetic Neuropathy, Painful
Safety and Efficacy Study of BC-DN-01 in Painful Diabetic Peripheral Neuropathy
A combined Phase 1 \& 2 study to evaluate the safety and effectiveness of a new diabetic neuropathy topical cream, containing benfotiamine, will be performed at 5 clinical sites and plans for BC-DN-01 administration in up to 135…
- Trial name
- NCT01793350
- Testing
- BC-DN-01 topically applied cream
- Where
- 5 sites in United Kingdom
- Sponsor
- BioChemics, Inc.
Painful Diabetic Peripheral Neuropathy
Gene Therapy for Painful Diabetic Neuropathy
The purpose of this open label, Phase I/II, dose-escalation, 3-cohort, multicenter, 12-month study, is to assess the safety and tolerability of injecting Engensis (VM202) in the leg muscle in patients with painful diabetic…
- Trial name
- NCT01002235
- Testing
- VM202
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Helixmith Co., Ltd.
Diabetic Neuropathy, Neuropathic Pain
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
Extended-release Pregabalin for the Treatment of Neuropathic Pain in Patients With Diabetic Peripheral Neuropathy and Postherpetic Neuralgia
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Neuralgia, Postherpetic
- Trial name
- PRISE (NCT07712913)
- Testing
- Experimental: Pregabalin XR, Comparator: Dorene Tabs
- Where
- 15 sites in Brazil
- Volunteers
- 348 people
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Diabetic Foot Ulcer
Effect of Virtual Reality on Pain, Anxiety and Vital Signs During Diabetic Foot Care
This study aims to determine the effects of a virtual reality (VR) intervention on pain level, state anxiety, and vital signs during foot care in individuals with diabetic foot ulcers.
- Trial name
- NCT07586423
- Testing
- VR, Standard Diabetic Foot Care
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Malatya Turgut Ozal University
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University