Clinical trials: Painful Neuropathy
Diabetic Foot Ulcer, Diabetic Wound
Peer Support for Patients With Diabetic Foot Ulcers
The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation…
- Conditions
- Diabetic Foot Ulcer, Diabetic Wound, Diabetes Mellitus, Type 2, Diabetic Foot
- Trial name
- NCT06004219
- Testing
- Peer counseling group
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Painful Diabetic Neuropathy
Study on the Role of Decompression of Lower Extremity Nerves for the Treatment of Patients With Symptomatic Diabetic Neuropathy With Chronic Nerve Compression
The UT Southwestern Medical Center at Dallas would like to give you information about a research study that is being done for patients with painful diabetic neuropathy and have not responded to medical treatment.
- Trial name
- DNND (NCT00703209)
- Testing
- Nerve Decompression
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Painful Lumbar Radiculopathy, Healthy
Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin)
The primary objective of the study is to evaluate the safety and tolerability of a range of single intravenous (IV) and subcutaneous (SC) doses of BG00010 in healthy volunteers, and a range of multiple SC doses of BG00010 in…
- Trial name
- NCT01842126
- Testing
- BG00010 IV, BG00010 SC
- Where
- Netherlands
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Biogen
Carpal Tunnel Syndrome
Lidocaine With Epinephrine vs. Bupivacaine With Epinephrine as Local Anesthetic Agents in Wide-awake Hand Surgery
This study is focused on comparing patients' pain scores on a visual analogue scale (VAS) and the difference in analgesics use post-operatively (with the same prescription defining only the maximum frequency) between lidocaine…
- Trial name
- NCT02315573
- Testing
- Wrist block anesthesia
- Where
- Canada
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Lumbar Radiculopathy
Effect of High Versus Low-level Laser Therapy in Patients of Lumber Radiculopathy
To Compare the effects of high-level laser therapy (HLLT) and low-level laser therapy (LLLT) on pain in patients with lumbar radiculopathy.
- Trial name
- NCT06240845
- Testing
- High-level laser therapy, Low-level laser therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Neuropathy;Peripheral
Depolarising Electrical Skin Stimulation in Neuropathic and Postoperative Pain
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
- Trial name
- NCT03037684
- Testing
- neurophysiology
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Carpal Tunnel Syndrome
Lidocaine Patch 1.8% for Moderate to Severe Pain From Carpal Tunnel Syndrome
The primary objective is to determine the efficacy of Lidocaine Patch 1.8% in reducing the severity of symptoms in participants with moderate-to-severe pain from Carpal Tunnel Syndrome.
- Trial name
- CTS (NCT04245371)
- Testing
- Lidocaine 1.8%
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- John Papakonstantinou, MD
Postoperative Pain, Carpal Tunnel Release
Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
The purpose of this study is to determine the efficacy of intra-operative administration of IV tylenol and/or IV toradol in minimizing post-operative pain for carpal tunnel patients and distal radius fracture patients.
- Conditions
- Postoperative Pain, Carpal Tunnel Release, Distal Radius Fracture
- Trial name
- NCT02313675
- Testing
- Acetaminophen, Ketorolac Tromethamine, Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- John Fowler
Acute Pain, Pain, Acute
Double-blind, Placebo-control, Study to Evaluate the Safety and Pharmacokinetics of CT-044 HCl, in Healthy Volunteers
This study will be conducted to assess safety, tolerability, and PK of CT-044 HCl in normal healthy volunteers, in a traditional sequential multiple ascending dose paradigm.
- Conditions
- Acute Pain, Pain, Acute, Surgery, Neuropathy
- Trial name
- NCT04175743
- Testing
- CT-044 HCl
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lotus Clinical Research, LLC
Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment
"Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients"
"This study aims to investigate ultrasonographic parameters of the median nerve in healthy individuals and patients with mild and moderate carpal tunnel syndrome (CTS).
- Conditions
- Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment, Electrophysiologic Study, Ultrasound
- Trial name
- NCT07408596
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Carpal Tunnel Syndrome
Cross-Cultural Adaptation and Psychometric Validation of the Turkish Version of Atroshi-Lyrén 6-item Symptoms Scale
This study aims to develop Turkish version of the Atroshi-Lyrén 6-item symptoms scale (A-L scale) and to perform validity and reliability evaluations.
- Trial name
- NCT05970692
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ilke KARA
Neuropathy, Diabetic, Neuropathy, Painful
Methods of Early Detection and Grading Of Diabetic Peripheral Neuropathy (MEDON)
MEDON aims to examine new methods for early detection and grading of diabetic peripheral neuropathy focusing on both small- and large nerve fibers.
- Trial name
- MEDON (NCT04078516)
- Testing
- Perception Threshold Tracking (PTT), Axon-flair mediated respons, Heart rate variability
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Chronic Pancreatitis
Pain Phenotypes in Chronic Pancreatitis
Chronic pancreatitis (CP) is characterised by recurrent abdominal pain. The pathological hallmarks of CP is pancreatic stellate cell activation that results in persistent inflammation and progressive fibrosis.
- Trial name
- PIP (NCT05713344)
- Testing
- Clinical history, Clinical examination, Evaluation of quality of life
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Small Fiber Neuropathy, Primary Sjögren Syndrome
Cutaneous Silent Period Assessment in Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a chronic, immune-mediated inflammatory disease mainly characterized by exocrine gland involvement.
- Trial name
- NCT05380804
- Testing
- cutaneous silent period (CSP) measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dry Needling, Carpal Tunnel Syndrome
Dry Needling and Rehabilitatin Carpal Tunnel Syndrome
Dry needling is used for myofascial release. However, its effectiveness in carpal tunnel syndrome (CTS) is not well known. It is thought that dry needling may also be an effective treatment for CTS by providing relaxation in the…
- Conditions
- Dry Needling, Carpal Tunnel Syndrome, Myofacial Pain
- Trial name
- NCT06358326
- Testing
- Dry needling, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Mitochondrial Diseases, Developmental Delay Disorder
Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental Disorders
Background: Small-Fiber-Neuropathy describes the degeneration of mildly or unmyelinated nerve fibers and causes neuropathic pain and autonomic dysfunction.
- Conditions
- Mitochondrial Diseases, Developmental Delay Disorder, Small Fiber Neuropathy, Cerebral Palsy
- Trial name
- SFN_children (NCT05645874)
- Testing
- Skin biopsy
- Where
- Germany
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Neuropathic Pain
Brain Activation During Thermal Stimulation in Neuropathic Pain
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following…
- Trial name
- NCT00525018
- Testing
- contact heat evoked potential stimulator
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Axonal Change, Neuronal, Pain
Effect of the Kv7-channel Opener Flupirtine on the Excitability of Human Peripheral Myelinated Axons in Vivo
Slow axonal Kv7 potassium channels are found along unmyelinated axons and at the nodes of Ranvier of myelinated axons in peripheral nerve.
- Trial name
- NCT01450865
- Testing
- flupirtine
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Spinal Cord Injuries, Pain, Neuropathic
Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain…
- Conditions
- Spinal Cord Injuries, Pain, Neuropathic, Nociceptive Pain, Neuropathy
- Trial name
- NCT06443281
- Testing
- Neurophysiology, Cardiovascular test, Experimental pain paradigms
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Carpal Tunnel Syndrome
Local Injection of Steroid VS.Glucose 5% in Carpal Tunnel Syndrome
To assess pain relief and quality of life among patients with carpal tunnel syndrome after local steroid vs. glucose 5% injection.
- Trial name
- NCT05496764
- Testing
- Dexamethasone, Glucose Injection
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Assiut University