Clinical trials: Painful Peripheral Neuropathy
Herpes Zoster, Postherpetic Neuralgia
Study to Find Out if Therapy With the Drug Pregabalin Relieves Pain During Shingles Compared With Placebo
The purpose of this study is to see if therapy with the drug pregabalin relieves pain during shingles compared with placebo. A placebo is an inactive substance.
- Trial name
- NCT00352651
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy, Peripheral Neuropathic Pain
Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), Food-effect of TRK-750
This is an exploratory, randomised, double-blind, placebo-controlled, Phase I study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and food-effect of single and multiple, ascending oral doses of TRK-750 in…
- Trial name
- NCT03346330
- Testing
- TRK-750
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Toray Industries, Inc
Neuralgia, Neuralgia; Postherpetic
Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic Pain
The investigators will evaluate the effectiveness and safety of acupuncture treatment in refractory neuropathic pain patients.
- Conditions
- Neuralgia, Neuralgia; Postherpetic, Diabetic Neuropathy, Painful, Failed Back Surgery Syndrome
- Trial name
- NCT03315598
- Testing
- Electroacupuncture
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Back Pain, Failed Back Surgery Syndrome
Epidural Pulsed Radiofrequency Treatment in Failed Back Surgery Syndrome
Low back pain can persist in some patients with history of back surgery. In some cases, an increase in pain may even occur, and chronic pain may make treatment more difficult.
- Conditions
- Back Pain, Failed Back Surgery Syndrome, Neuropathic Pain
- Trial name
- NCT06239857
- Testing
- Epidural pulsed radiofrequency
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Nerve Pain, Neuropathic Pain
PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin
The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain with Spinal or Peripheral Nerve Origin.
- Conditions
- Nerve Pain, Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic)
- Trial name
- NCT06599151
- Testing
- [18F]FTC-146
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Carpal Tunnel Syndrome
Local Injection of Steroid VS.Glucose 5% in Carpal Tunnel Syndrome
To assess pain relief and quality of life among patients with carpal tunnel syndrome after local steroid vs. glucose 5% injection.
- Trial name
- NCT05496764
- Testing
- Dexamethasone, Glucose Injection
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neuropathy, Diabetic, Pain, Neuropathic
Balance and Gait in Diabetic Neuropathy
The aim of the study is to evaluate the effects of neuropathic pain due to type 2 diabetes on balance and gait. The study is a prospective controlled study.
- Conditions
- Neuropathy, Diabetic, Pain, Neuropathic, Gait Disorder, Sensorimotor
- Trial name
- NCT05127538
- Testing
- Gait analysis, Balance Assessment
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Baskent University
Piriformis Muscle Syndrome, Anthropometry
Pelvic and Hip Morphometry in Piriformis Syndrome
In this case-control study, 23 patients diagnosed as PS by diagnostic injection with ultrasound guidance were selected as the study group.
- Trial name
- NCT04600024
- Testing
- Ultrasound guided diagnostic injection
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Piriformis Syndrome
Soft Tissue Techniques in Piriformis Syndrome
The purpose of the study is to compare the effects of active release technique and post isometric relaxation in patients with piriformis syndrome on pain, hip internal rotation range of motion and functional disability.
- Trial name
- NCT04842656
- Testing
- Post isometric relaxation, Active release technique alongwith conventional treatment
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Neurofibromatosis 1, Plexiform Neurofibromas
Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)
Background: People with neurofibromatosis 1 (NF1) who have plexiform neurofibromas (pNFs) can have pain that affects their daily lives.
- Trial name
- NCT02544022
- Where
- 6 sites in United States
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Pain, Neuropathic, Pain, Acute
Ice Immersion Using Virtual Reality & Augmented Reality
The purpose of this study is to evaluate the effectiveness of different technologies, Virtual Reality and Augmented Reality with modifications as passive content, active content, cognitive load modulation, and positive…
- Trial name
- NCT04196686
- Testing
- VR/AR, Ice Bath
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Stanford University
Morton Neuroma
Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma
Morton's neuroma is a benign thickening involving the plantar interdigital nerve, most common in middle aged women. Morton's neuroma is one of the most frequent diagnoses seen in the investigators podiatry clinic and is difficult…
- Trial name
- NCT05501262
- Testing
- Cryoablation, Nerve block
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cold Hypersensitivity, Vascular System Injuries
Treatment of Frostbite Sequelae With Botulinum Toxin A
Background Digital vasospasm as part of frostbite sequelae is comparable to the vasospastic disorders found in Raynaud's phenomenon which has been successfully treated with Botulinum toxin type A injections in the palm of the…
- Conditions
- Cold Hypersensitivity, Vascular System Injuries, Vibration; Disorder, Sensory Disorders
- Trial name
- NCT06460194
- Testing
- Botuinum toxin
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Acute Pain, Chronic Pain
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery.
- Conditions
- Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
- Trial name
- NCT05023278
- Testing
- Venlafaxine 37.5 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetic Neuropathies
Clinical Trial Designed to Determine the Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy
The study consists of two periods, the Screening Period (~3 weeks) and Treatment Period (12 weeks). Eligibility for the study will be determined by Screening tests, physical examination/medical history, and fulfilment of…
- Trial name
- NCT02435199
- Testing
- EMA401 600mg
- Volunteers
- healthy volunteers welcome
- Sponsor
- Spinifex Pharmaceuticals Pty Ltd
Neuropathic Pain, Osteo Arthritis Knee
WHIRLPOOL FOR OSTEOARHRITIS
Both neuropathic and nociceptive mechanisms may contribute to the OA pain experience. Aims: The aim of this study was to determine the efficacy of warm whirlpool on pain, disability, quality of life (QoL) and sleep for patients…
- Conditions
- Neuropathic Pain, Osteo Arthritis Knee, Sleep Disorder
- Trial name
- NCT03299114
- Testing
- Whirlpool
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Neuropathic Pain
Comparison of Pain-Related Changes in Cerebral Blood Volume in Burn Patients With Neuropathic Pain
The investigators will observe increased or decreased CBV in patients with thermal injury compared with the CBV in healthy controls.
- Trial name
- NCT04125576
- Testing
- magnetic resonance imaging(MRI)
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hangang Sacred Heart Hospital
Peripheral Nerve Injuries
Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries
The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g.
- Trial name
- NCT03082820
- Testing
- Pain-related evoked potentials (PREP), Quantitative Sensory Testing (QST), Nerve conduction studies (NCS)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Neuropathic Pain
Development of Stimulator Pneumatic for Realization of Evoked Potential Allodynic/Somatosensory
The stimuli used in the evoked potentials are electrical or laser. They are started and synchronized with the collection of the EEG by signals TTL (transistor-transistor logic).
- Trial name
- STIMEA (NCT02527590)
- Testing
- pneumatic stimulations(allodynic area), pneumatic stimulations (healthy area), pneumatic stimulations no auditory masking
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pain
Descriptive Study of Pain, Anxiety and Depression
The purpose of the study is to investigate pain, anxiety and depression in chronic pain patients with and without neuropathic pain compared with healthy volunteers
- Trial name
- NCT00378274
- Testing
- Observation
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Danish Pain Research Center