Clinical trials: Palliative Cancer
Cancer, Palliative Care, Patient Care
Dexmedetomidine for Refractory Pain in Palliative Cancer Patients
The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids).
- Conditions
- Cancer, Palliative Care, Patient Care, Pain Management, Dexmedetomidine Analgesia
- Trial name
- DEX-PAL (NCT07885475)
- Where
- 4 sites in Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Cervical Cancer Recurrent or Persistent, Palliative Treatment
Combination of Nimotuzumab Cisplatin-Vinorelbine in First Line Chemotherapy in Recurring-Persistent Cervical Carcinoma
This study evauates the global survival of patients following administration of mAb Nimotuzumab hR3 + chemotherapy in the treatment of cervical cancer in first line therapy, after relapsing from chemo-radiotherapy.
- Conditions
- Cervical Cancer Recurrent or Persistent, Palliative Treatment, Monoclonal Antibody in Cervical Cancer Treatment
- Trial name
- NCT02083211
- Testing
- mAb Nimotuzumab
- Where
- Mexico
- Volunteers
- 168 people
- Sponsor
- National Institute of Cancerología
Health Services Research
Effectiveness of the Supportive and Palliative Care Review Kit (SPARK) for Cancer Patients in the Acute Hospital
Introduction There is a rising need for palliative care services in Singapore due to a rapidly ageing population and an increasing incidence of cancer.
- Trial name
- NCT03330509
- Testing
- SPARK intervention
- Where
- Singapore
- Volunteers
- 7,514 people
- Sponsor
- National Cancer Centre, Singapore
Bone Cancer, Bone Metastases
Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and Multiple Myeloma
The goal of this study is to collect comparative data on safety and efficacy of MR Guided Focused Ultrasound and External Beam Radiation for treatment of metastatic bone tumors or multiple myeloma.
- Conditions
- Bone Cancer, Bone Metastases, Pain
- Trial name
- NCT01091883
- Testing
- Exablate treatment, Radiation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- InSightec
Neoplasms
Increasing Patient Comfort in Palliative Radiotherapy With a Newly Developed Mattress - A Prospective Clinical Study
The goal of this research is to determine if a new radiotherapy mattress is more comfortable for patients than the standard mattress. The table of the CT scanner and the radiation machine is flat and hard.
- Trial name
- RTCOMFORT (NCT06903507)
- Testing
- RT-Comfort Mattress
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Erasmus Medical Center
Mindfulness, Meditation
Mindfulness to Enhance Quality of Life and Support Advance Care Planning
The MEANING trial is a randomized controlled mixed methods pilot designed to compare a novel mindfulness meditation-based intervention (MEANING) to usual care for adults with advanced-stage solid malignancies and their family…
- Conditions
- Mindfulness, Meditation, Metastatic Cancer, Quality of Life
- Trial name
- MEANING (NCT03257007)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cancer, Lymphoma
Study to Test a Computer-assisted Support System to Improve Patient-centered Care and Symptom Relief in Cancer Patients
Patient-provider shared decision making and the inclusion of patients' illness experiences and preferences in patient care are prioritized areas in health care.
- Conditions
- Cancer, Lymphoma, Leukemia, Stem Cell Transplantation
- Trial name
- NCT00709813
- Testing
- Tailored assessments provided to physicians and nurses (CHOICE, the Computer-assisted Interactive Tailored Patient Assessment Tool (ITPA))
- Volunteers
- 145 people
- Sponsor
- Oslo University Hospital
Lung Cancer
Stepped Palliative Care Versus Early Integrated Palliative Care in Patients With Advanced Lung Cancer
This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer
- Trial name
- STEP PC (NCT03337399)
- Testing
- Stepped PC, Early Integrated PC
- Where
- 3 sites in United States
- Volunteers
- 507 people
- Sponsor
- Massachusetts General Hospital
Pancreatic Cancer
Early Palliative Care in Pancreatic Cancer - a Quasi-experimental Study
The aim of the proposed study is to understand the palliative care needs of patients with pancreatic cancer, to investigate whether early palliative care can improve patient outcomes and reduce use of health care services, and to…
- Trial name
- PanEffort-1 (NCT04290364)
- Testing
- Palliative care
- Where
- Denmark
- Volunteers
- 74 people
- Sponsor
- Inge Høgh Dufva
Cancer, Congenital Heart Disease
Supporting Patient Provider Communication in Paediatric Care
Children with Cancer or congenital heart disease (CHD) experience complex, physical, psychosocial and behavioural symptoms and problems due to the illness, treatment, and medical procedures.
- Trial name
- SiSom (NCT01280227)
- Testing
- SiSom
- Where
- Norway
- Volunteers
- 144 people
- Sponsor
- Oslo University Hospital
Sleep, Insomnia
Pharmacological Treatment of Insomnia in Palliative Care
Sleep disturbance is frequent in patients with advanced cancer and decreases the tolerability of other symptoms and impairs quality of life.
- Trial name
- NCT02807922
- Testing
- Zopiclone
- Where
- 5 sites in Norway
- Volunteers
- 43 people
- Sponsor
- St. Olavs Hospital
Cancer, Bone Metastases
Magnetic Resonance Guided High Intensity Focused Ultrasound (MRgHIFU) for Pain Palliation of Bone Metastases
The primary objective of this study is to determine whether intra- and post-procedural MR changes are indicative of reduction in pain symptom scores.
- Trial name
- HIFU-Bone (NCT03479151)
- Testing
- Magnetic Resonance Image-guided High Intensity Focused Ultrasound (MR-HIFU)
- Where
- United Kingdom
- Sponsor
- Institute of Cancer Research, United Kingdom
Non-Small Cell Lung Cancer
Radiation Therapy to Relieve Symptoms in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
This study will test the safety of Quad Shot radiation therapy using 2 different treatment schedules to find out what effects, if any, this treatment has on people with advanced NSCLC who are receiving systemic therapy for their…
- Trial name
- NCT04384146
- Testing
- Cyclical Hypofractionated Palliative Radiation (Quad Shot), EORTC QLQ-C30 questionnaire
- Where
- 7 sites in United States
- Volunteers
- 41 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Life-limiting Illness, Breast Cancer
Therapeutic Support to Strengthen Dignity, Mental Well-being and Quality of Life in Acute Palliative Care Patients.
The goal of this clinical trial is to test the benefit of a newly designed personalized therapeutic intervention compared to the standard specialized palliative care service at the swiss acute palliative hospital care.The main…
- Conditions
- Life-limiting Illness, Breast Cancer, Glioblastoma, Prostate Cancer
- Trial name
- NCT06549075
- Testing
- Therapeutic support, Standard Specialized Palliative Consultation Service
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Basel, Switzerland
Cancer, Pain
Symptom Clusters in Cancer Patients and Their Caregivers- a Longitudinal Study
The complexity of cancer patients' symptoms and health problems constitutes considerable distress and burden for patients and their family caregivers.
- Conditions
- Cancer, Pain, Fatigue, Depression
- Trial name
- NCT00769301
- Where
- 3 sites in Norway
- Volunteers
- 570 people
- Sponsor
- Oslo University Hospital
Advanced Cancer
Palliative Care Referral System (PCRS) for Cancer Patients With Advanced Disease
Early palliative care (EPC) in the clinical pathway of advanced cancer patients improves symptom control, quality of life and has a positive impact on overall quality of care.
- Trial name
- PCRSS (NCT04936568)
- Testing
- Palliative Care Referral System - PCRS
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Non-small Cell Lung Cancer
Phase II Trial of Erlotinib and Concurrent Palliative Thoracic Radiation Therapy for Non-small Cell Lung Cancer (PEARL)
To improve the clinical outcomes of patients with non-small cell lung cancer treated with radiation therapy.
- Trial name
- NCT00391248
- Testing
- Erlotinib
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Nausea, Vomiting
Treatment Algorithm for Nausea and Vomiting in the Palliative Phase
Nausea and vomiting are frequently occurring problems in the palliative phase of patients with cancer. Between 20-50% of them regularly suffer from nausea, retching or vomiting.
- Conditions
- Nausea, Vomiting, Cancer
- Trial name
- NCT03017391
- Testing
- metoclopramide, granisetron, Dexamethasone
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Advanced Cancer
Feasibility of Home vs. Hospital Based Resistance Training for Advanced Cancer Patients
Cancer causes 8.2 million deaths each year, with an estimated worldwide cost of $895 billion. Pharmacological treatments provide improvements in expected survival and symptoms, but at cost of a high rate of toxicities and…
- Trial name
- NCT02930876
- Testing
- Resistance training
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- King's College London
Cancer, Breast Cancer
Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors
The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult (AYA) cancer survivors manage symptoms and engage in recommended…
- Conditions
- Cancer, Breast Cancer, Colorectal Cancer, Sarcoma
- Trial name
- AYA STEPS (NCT06371768)
- Testing
- AYA Educational Information, AYA STEPS
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Duke University
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